Abstract:BACKGROUNDTreatment-refractory visceral leishmaniasis (VL) has become an important
problem in many countries.OBJECTIVESWe evaluated the antimony-resistance mechanisms of Leishmania
infantum isolated from VL patients refractory or responsive to
treatment with pentavalent antimony.METHODSStrains isolated from antimony-refractory patients (in vitro
antimony-resistant isolates) and antimony-responsive patients (in
vitro antimony-sensitive isolates) were examined. Morphological
changes were evaluated by transmissio…
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