volume 113, issue 2, P119-125 2018
DOI: 10.1590/0074-02760170289
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Abstract: BACKGROUNDTreatment-refractory visceral leishmaniasis (VL) has become an important problem in many countries.OBJECTIVESWe evaluated the antimony-resistance mechanisms of Leishmania infantum isolated from VL patients refractory or responsive to treatment with pentavalent antimony.METHODSStrains isolated from antimony-refractory patients (in vitro antimony-resistant isolates) and antimony-responsive patients (in vitro antimony-sensitive isolates) were examined. Morphological changes were evaluated by transmissio…

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