Increased Synthesis of Anti-Tuberculous Glycolipid Immunoglobulin G (IgG) and IgA with Cavity Formation in Patients with Pulmonary Tuberculosis

Mizusawa, Masako; Kawamura, Mizuoho; Takamori, Mikio; Kashiyama, Tetsuya; Fujita, Akira; Usuzawa, Motoki; Saitoh, Hiroki; Ashino, Yugo; Yano, Ikuya; Hattori, Toshio

doi:10.1128/cvi.00355-07

Cited by 25 publications

(24 citation statements)

References 22 publications

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“…Moreover, by using ROC analysis, we found that anti-TDM-M and anti-TBGL IgG had similar area under the curve (AUC), but AUC of anti-TBGL IgG improved when MAC positive subjects were excluded. We also noticed that the average anti-TBGL titers and the proposed cut-off levels appear to vary according to severity of the disease and the origin of the studied subjects [6,7,[28][29][30][31].…”

Section: Accepted Manuscriptmentioning

confidence: 93%

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Senoputra

Shiratori

Hasibuan

et al. 2015

Diagnostic Microbiology and Infectious Disease

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Section: Accepted Manuscriptmentioning

confidence: 93%

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Senoputra

Shiratori

Hasibuan

et al. 2015

Diagnostic Microbiology and Infectious Disease

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“…Anti-M. tuberculosis IgG antibodies have been shown to increase in patients with active disease (3,11,13,16). While the function of anti-M. tuberculosis antibodies in providing protective immunity is still under investigation, it has been proposed that they may be utilized as a diagnostic marker of active disease (1,2,7).…”

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confidence: 99%

Antituberculosis IgG Antibodies as a Marker of Active Mycobacterium tuberculosis Disease

Welch¹,

Lawless²,

Litwin³

2012

Clin. Vaccine Immunol.

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ABSTRACTAnti-Mycobacterium tuberculosisIgG antibodies may aid in the diagnosis of activeM. tuberculosisdisease. We studied whether anti-M. tuberculosisIgG antibodies are elevated in activeM. tuberculosisdisease and assessed factors contributing to false-positive and -negative results. A retrospective study of 2,150 individuals tested by the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay was conducted at the University of Utah, ARUP Laboratories, November 2008 to December 2010. All samples were tested with the InBios Active TbDetectantituberculosis (anti-TB) IgG antibody assay. Of 1,044 patients with a positive QFT-GIT, 59 (5.7%) were positive forM. tuberculosisantibodies. Fourteen of 1,106 (1.3%) with a negative or indeterminate QFT-GIT were positive forM. tuberculosisantibodies.M. tuberculosisantibody tests were positive in 61.5% with confirmed activeM. tuberculosisdisease and other mycobacterial infections. Over half of the false-negativeM. tuberculosisantibody tests occurred in patients ≥90 years of age. False positives were seen in 12.9% of autoimmune patients. The odds ratio of being positive by the QFT-GIT and the InBios TB IgG assay increased with confirmedM. tuberculosisdisease or highly suspectedM. tuberculosisdisease and was 86.7 (95% confidence interval [CI], 34.4 to 218.5) in these two groups compared to patients negative by both tests. Although anti-M. tuberculosisantibodies can be detected in patients with activeM. tuberculosisdisease, caution should be used with patients where immunoglobulin levels may be decreased or patients with autoantibodies.

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“…Recently, we reported the increased synthesis of anti-TBGL IgG in relation to cavity formation in pulmonary tuberculosis and elevated titers of C-reactive protein, which suggest that TBGL IgG could reflect inflammation in active pulmonary TB patients. (Mizusawa et al 2008). Additionally, the anti-TBGL antibody is not influenced by prior BCG vaccination (Nabeshima et al 2005).…”

Section: Discussionmentioning

confidence: 94%

High Numbers of Interferon-.GAMMA.-Producing T Cells and Low Titers of Anti-Tuberculous Glycolipid Antibody in Individuals with Latent Tuberculosis

Guio

Ashino

Saitoh

et al. 2010

Tohoku J. Exp. Med.

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Increased Synthesis of Anti-Tuberculous Glycolipid Immunoglobulin G (IgG) and IgA with Cavity Formation in Patients with Pulmonary Tuberculosis

Abstract: Tuberculous glycolipid (TBGL) antigen is a cell wall component of

Cited by 25 publications

References 22 publications

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Diagnostic value of antibody responses to multiple antigens from Mycobacterium tuberculosis in active and latent tuberculosis

Antituberculosis IgG Antibodies as a Marker of Active Mycobacterium tuberculosis Disease

High Numbers of Interferon-.GAMMA.-Producing T Cells and Low Titers of Anti-Tuberculous Glycolipid Antibody in Individuals with Latent Tuberculosis

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