Increased susceptibility to pulmonary infection in alloxan diabetic mice

Hebert, James C.; Coil, James A.

doi:10.1016/0022-4804(81)90058-5

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…Winterbauer et al (2) found that diabetes was second only to alcoholism among extrathoracic illnesses predisposing to recurrent bacterial pneumonia, occurring in 12.7% of 158 patients. Animal studies suggest that alloxan-induced diabetes is associated with increased mortality from pneumonia induced by intrabronchial instillation or aerosolization of Pneumococci and that insulin therapy decreases this susceptibility (27).…”

Section: Discussionmentioning

confidence: 99%

Bacterial Phagocytosis and Intracellular Killing by Alveolar Macrophages in BB Rats

et al. 1988

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Diabetic patients and animals show an increased susceptibility to bacterial infections due to impaired bactericidal function of various host-defense mechanisms. In our study, we examined the ability of alveolar macrophages (AMs) of the diabetic BB rat to phagocytize and kill Staphylococcus aureus bacteria. Groups of spontaneously diabetic BB rats with variable severity of diabetes were used and compared with non-diabetes-prone BB rats. AMs obtained from diabetic insulin-deficient BB rats showed a markedly decreased capacity to phagocytize and kill bacteria, a defect that was partially corrected after a period of aggressive insulin treatment. Glucose-intolerant BB rats and diabetes-prone BB rats who did not develop diabetes showed a normal AM function compared to non-diabetes-prone BB rats. The impaired phagocytotic and bactericidal functions of AMs appeared to be caused by a cellular abnormality associated with the degree of insulin deficiency.

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Section: Discussionmentioning

confidence: 99%

Bacterial Phagocytosis and Intracellular Killing by Alveolar Macrophages in BB Rats

et al. 1988

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“…Data from in vitro experiments indicates that hyperglycemia-induced hyperosmolarity is the depressive factor associated with inferior phagocytic defense [20]. To mimic the natural path of pneumococcus infection, Hebert et al [21] exposed alloxaninduced diabetic mice to an aerosol containing 10 8 type III Streptococcus pneumoniae/ml, and monitored the ability of the pulmonary barrier to defend against infection. In that study, the survival rate of diabetic mice was lower than that of non-diabetic mice.…”

Section: Diabetic Animal Models Of Respiratory Infectionsmentioning

confidence: 99%

Diabetic Animal Models with Infectious Diseases: Focus on the Dysfunction of Immune System

Yeh¹

2014

J Diabetes Metab

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Diabetes Mellitus (DM) is a metabolic disease that can lead to a variety of complications, such as neuropathy, retinopathy, nephropathy, and cardiovascular disease. Furthermore, pathogen infection accompanied by considerable morbidity and mortality is common among diabetic patients. Increased susceptibility to pathogen infection results from impaired immune responses, such as lower cytokine production and reduced function or migration of immune cells. However, existing clinical data remains controversial because multiple diabetes-related factors such as obesity, hyperglycemia, hyperinsulinemia, and other comorbidities also increase the risk of infection. In recent decades, several animal models have been used to investigate the role played by immune dysfunction in increasing susceptibility to pathogens and related diseases in diabetes. This review focuses on studies that used diabetic animal models to study infectious diseases and summarizes potential mechanisms underlying dysfunction of the immune system in diabetes patients. J ou rna l o f D ia be tes & M e ta bolism

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“…The method for exposure has been previously described elsewhere. 16 Briefly, a commercial airborne infection apparatus with a venturi nebulizer to create a bacterial aerosol was used.…”

Section: Experimental Designmentioning

confidence: 99%

Improved Survival After Pneumococcus in Splenectomized and Nonsplenectomized Mice With Corynebacterium parvum

Hebert¹,

Gamelli²,

Foster³

et al. 1983

Arch Surg

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Increased susceptibility to pulmonary infection in alloxan diabetic mice

Cited by 9 publications

References 18 publications

Bacterial Phagocytosis and Intracellular Killing by Alveolar Macrophages in BB Rats

Bacterial Phagocytosis and Intracellular Killing by Alveolar Macrophages in BB Rats

Diabetic Animal Models with Infectious Diseases: Focus on the Dysfunction of Immune System

Improved Survival After Pneumococcus in Splenectomized and Nonsplenectomized Mice With Corynebacterium parvum

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