Increased Serum Osteoprotegerin Levels Associated with Decreased Bone Mineral Density in Familial Mediterranean Fever

Yüksel, Şeref; Şamlı, Hale; Çölbay, Mehmet; Dündar, Ümit; Acartürk, Gürsel; Demir, Serap; Köken, Tülay; Aktepe, Orhan Cem; Kavuncu, Vural; Solak, Mustafa

doi:10.1620/tjem.217.321

Cited by 21 publications

(19 citation statements)

References 42 publications

(28 reference statements)

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“…However, there was no statistically signiWcant diVerence between the three groups regarding BMD, and Z and T scores. This result puts forward that the type of mutation in FMF does not have an eVect on osteoporosis, which was also supported by the literature [4,7].…”

Section: Discussionsupporting

confidence: 87%

“…In the present study, we included more number of patients and investigated all of these parameters and did not determine bone loss in patients with FMF. The mean disease durations in these studies were 14 years in Yuksel et al's [7] study and 12 years in Yildirim et al's study, and the median disease duration was 5 years (2-10 years) in Suyani et al's study [8], whereas in the present study, it was 15.3 years, which suggests that the disease duration does not have an eVect on BMD in FMF. We did not Wnd a correlation between the disease duration and bone loss anyway, and nothing was mentioned on this subject in similar studies [6][7][8].…”

Section: Discussioncontrasting

confidence: 48%

“…Yuksel et al [7] in a study of 31 patients with FMF found L1-4 BMD and its Z score lower than the controls. There was no diVerence in proximal femur values.…”

Section: Discussionmentioning

confidence: 91%

“…From this point of view, it was suggested that osteoporosis may be seen in patients with FMF. Despite conXicting results and diVerences in methodology, this suggestion was supported by a few studies as well [6][7][8].…”

Section: Introductionmentioning

confidence: 96%

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Bone mineral density in familial Mediterranean fever

et al. 2011

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The aim of this study was to evaluate the bone mineral density (BMD) in familial Mediterranean fever (FMF) and to search the effects of genetic factors, family history of FMF and types of clinical attacks on BMD. Forty-four attack-free patients with FMF and 36 healthy voluntary subjects were included in the study. BMD measurements of lumbar spine and left proximal femur were performed by dual energy X-ray absorptiometry (DEXA). There was no statistically significant difference between patient and control groups regarding median values of lumbar BMD (P = 0.06), lumbar T (P = 0.08) and Z (P = 0.12) scores, femoral neck BMD (P = 0.13), femoral T (P = 0.22) and Z (P = 0.16) scores and total femur BMD (P = 0.14), T (P = 0.19) and Z (P = 0.27) scores. Patients with negative FMF family history had significantly lower femoral neck BMD (P = 0.018), femoral neck T (P = 0.009) and Z (P = 0.01) scores and total femur BMD (P = 0.033) than patients with positive FMF family history. There was no significant difference among the groups regarding mutation characteristic and types of attacks in lumbar BMD, T and Z scores, femoral neck BMD, T and Z scores and total femur BMD, T and Z scores (P > 0.05). We found that the bone loss of patients with FMF is not different from that of the controls. The increased bone loss in the patients with negative family history for FMF should be further investigated with larger patient groups taking into consideration of the risk factors related to family history for osteoporosis.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 48%

“…Yuksel et al [7] in a study of 31 patients with FMF found L1-4 BMD and its Z score lower than the controls. There was no diVerence in proximal femur values.…”

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 96%

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Bone mineral density in familial Mediterranean fever

et al. 2011

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“…3 The relationship between BD and osteoporosis has not been studied intensively before but there are many studies on other rheumatic diseases such as familial Mediterranean fever and rheumatoid arthritis, which have similar etiopathogenesis with BD. 7 Behçet's disease is a chronic and complex disorder. Many organs can be involved.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Kutlucan¹,

Tunc²,

Baltaci³

et al. 2012

Dicle Med J

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ÖZETAmaç: Behçet hastalığı (BH)'nın doğal seyri sırasında ya da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir. Çalışmanın amacı BH'nda osteoprotegerin ve tümor nekroz faktör (TNF-α) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır. Gereç ve yöntem:Çalışmaya, hasta grubu ve kontrol grubu olarak iki grup alındı. TNF-α, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi (KMD) ölçüldü ve iki grup karşılaştırıldı. Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36 hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.26±11.64 ve 41.66±70.99 bulundu. Vücut kitle indeksi yönünden iki grup arasında fark bulunmadı. TNF-α (p<0.001), deokspiridinolin (p<0.001) ve osteokalsin (p=0.041) düzeyleri kontrol grubundan önemli oranda yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda düşüktü ancak anlamlı düzeyde değildi (p>0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grubunda kontrol grubuna göre anlamlı yüksekti (p=0.03). Hasta grubun KMD ölçümü; L2-L4 hariç, kontrol grubuna göre anlamlı oranda düşüktü (sırasıyla p<0.001, p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 ve p=0.111). TNF-α ve osteoprotegerin arasında korelasyon saptanmadı.Sonuç: Bu çalışmada TNF-α ve KMD arasında negatif korelasyon saptandı ve TNF-α'nın, BH'da osteoporotik süreci etkilediği bulundu. Osteoprotogerin düzeyi düşük-lüğü anlamlı değildi ve TNF-α ile korele değildi.Anahtar kelimeler: Behçet hastalığı, osteoprotegerin, TNF-α, osteokalsin ABSTRACT Objectives: Osteoporosis is commonly developed due to natural course of Behçet's disease (BD) and therapeutic agents. It was aimed to investigate levels of osteoprotegerin and TNF-α (tumor necrosis factor), and bone mineral density (BMD) and correlation between them in BD. Materials and methods:The study included two groups as the study and the control group. Serum levels of TNF-α, osteoprotegerin, osteocalcine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and urinary creatinine and deoxypyridinoline along with BMD level were evaluated and compared. Correlation between TNF-α and osteoprotegerin level was investigated. Results:The study enrolled 41 BD patients and 36 agedmatched control subjects. Mean age was 42.26±11.64 and 41.66±70.99, in the study and control groups, respectively. There was no significant difference in body mass index (BMI) of subjects between groups (p>0.05). Level of TNF-α (p<0.001), deoxypyridinoline (p<0.001) and osteocalcine (p=0.041) was significantly higher in the study group compared to the control group. Osteoprotegerin was lower in BD patients, but the difference was not significant (p>0.05). Urinary deoxypyridinoline/ urinary creatinine ratio in patients with BD was significantly higher than those in control group (p=0.030). Patients had significantly lower BMD comparfed to the control group, except L2-L4 vertebral area (p<0.001, p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 and p=0.111, respectively). No correla...

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Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period

et al. 2011

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To evaluate the circulating levels of adipokines (leptin and adiponectin) and ghrelin in patients with familial Mediterranean fever (FMF) and also to assess the relationships between these molecules and disease-related parameters. Forty-eight FMF patients in attack-free period (31 men, [M], 17 women, [F], mean age 35.8 ± 8.6 years, and a mean body mass index [BMI] of 24.7 ± 3.1) and 40 age-, sex-, and BMI-matched healthy controls (24 M, 16 F, mean age 35.5 ± 8.5 years, and a mean BMI of 24.5 ± 2.8) were included in the study. Patients and controls with a history of any other chronic diseases and obese or underweight subjects were excluded. High-sensitive C-reactive protein (hs-CRP), leptin, adiponectin, and total ghrelin concentrations were studied. Age, sex, BMI, waist circumference, and smoking status were similar between FMF patients and controls (P > 0.05). Adipose tissue-derived molecules including leptin, and adiponectin were lower than healthy controls but only adiponectin levels reached the statistically significance (16.7 ± 8.9 ng/ml vs. 27.7 ± 15.9 ng/ml, P < 0.001) and leptin concentrations just missed significance (25.2 ± 16.2 ng/ml vs. 34.9 ± 27.2 ng/ml, P = 0.051). Ghrelin concentrations were not different between the groups. Adiponectin levels were significantly and negatively correlated with hs-CRP (P < 0.05, r = -0.24). The results of this study suggest that low-grade chronic inflammation during attack-free period in FMF patients may suppress adiponectin production or low levels of adiponectin might contribute to subclinical inflammation in these patients.

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Increased Serum Osteoprotegerin Levels Associated with Decreased Bone Mineral Density in Familial Mediterranean Fever

Cited by 21 publications

References 42 publications

Bone mineral density in familial Mediterranean fever

Bone mineral density in familial Mediterranean fever

Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Down-regulation of adiponectin in patients with familial Mediterranean fever during attack-free period

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