Increased Serum Levels of Oxytocin in ‘Treatment Resistant Depression in Adolescents (TRDIA)’ Group

Sasaki, Tsuyoshi; Hashimoto, Kenji; Oda, Yasunori; Ishima, Tamaki; Yakita, Madoka; Kurata, Tsutomu; Kuno, Masaru; Takahashi, Jumpei; Kamata, Y U; Kimura, Atsushi; Niitsu, Tomihisa; Kobara, Hideki; Hasegawa, Tadashi; Shiina, Akihiro; Hashimoto, Tasuku; Kanahara, Nobuhisa; Shimizu, Eiji; Iyo, Masaomi

doi:10.1371/journal.pone.0160767

Cited by 25 publications

(15 citation statements)

References 25 publications

(23 reference statements)

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“…The association between oxytocin and prosocial behavior has not been measured during adolescence, although one study shows that adolescent males with higher salivary oxytocin levels report fewer conduct problems [82], which can be cautiously interpreted as more prosocial behavior. Finally, one study reported elevated oxytocin levels in adolescents with treatment-resistant MDD, compared to non-treatment resistant and healthy control adolescents [83•]. However, the association between prosocial behavior and oxytocin in pubertal patients with MDD remains to be studied.…”

Section: Oxytocin and Testosteronementioning

confidence: 99%

Prosocial Behavior and Depression: a Case for Developmental Gender Differences

Alarcón

Forbes

2017

Curr Behav Neurosci Rep

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Purpose of Review Prosocial behavior and depression are related constructs that both increase during adolescence and display gender-specific effects. The current review surveys literature examining the association between depressive symptoms and prosociality, measured with behavioral economic paradigms, across development and proposes a theoretical model explaining a mechanism through which adolescent girls have higher risk for depression than boys. Recent Findings Relative to healthy controls, prosocial behavior is reduced in adults with major depressive disorder (MDD) but may be increased in adolescents with MDD. The relationship between non-clinical levels of depressive symptoms and prosocial behavior remains to be studied experimentally; however, self-reported prosocial behavior is negatively associated with depressive symptoms in non-clinical adolescents, which may suggest a shift in the relation of prosocial behavior and depressive symptoms across the non-clinical (i.e., negative) to clinical range (i.e., positive). Summary The effect of gender on these developmental and clinical status shifts has not been studied but could have important implications for understanding the emergence of higher rates of depression in girls than boys during adolescence. We propose that girls are at heightened risk for depression due to higher social-evaluative concern and other-oriented prosocial motivation that emphasize the needs of others over the self, leading to more altruistic prosocial behavior (despite personal cost) and a higher burden that enables depressive symptoms.

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Section: Oxytocin and Testosteronementioning

confidence: 99%

Prosocial Behavior and Depression: a Case for Developmental Gender Differences

Alarcón

Forbes

2017

Curr Behav Neurosci Rep

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“…In previous reports, the serum OXT levels in women with post-traumatic stress disorder (PTSD) associated with a traffic accident, PTSD associated with other events, and women with schizopherenia were reported to be 69.5±32.7 pg/mL ( 23 ), 101.59±55.89 pg/mL ( 24 ), and 100±35 pg/mL ( 25 ), respectively. Attention deficit hyperactivity disorder (ADHD) ( 26 , 27 ) and autism spectrum disorder (ASD) ( 28 , 29 ) in children as well as treatment-resistant depression in adolescents ( 30 ) are reported to be associated with OXT levels. Depression was only reported to be associated with OXT levels based on the RIA method ( 5 , 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

The Relationship between the Serum Oxytocin Levels, Disease Activity, the ADLs and the QOL in Patients with Rheumatoid Arthritis

et al. 2017

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Objective To investigate the factors associated with depression, including the serum oxytocin (OXT) levels, disease activity, activities of daily living (ADLs) and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods This study included 42-RA-patients. We measured the following variables before and after 6 months of treatment with biological disease-modifying antirheumatic drugs (bDMARDs): the baseline characteristics (including age, sex, disease duration, smoking, and body mass index), the doses of prednisolone and methotrexate, the serum level of matrix metalloprotease-3, the erythrocyte sedimentation rate and the C-reactive protein level. The disease activity of RA was assessed using the Simplified Disease Activity Index (SDAI), depression was assessed using the Hamilton Depression Rating Scale (HAM-D), the ADLs were assessed using the Health Assessment Questionnaire disability index and the QOL was assessed using the Short Form (SF)-36. The serum OXT levels were determined using an enzyme-linked immunosorbent assay. Results The HAM-D score was significantly correlated with the SDAI, and the mental component summary score of the SF-36. However, the serum OXT levels were not correlated with the HAM-D score. The serum OXT levels before and after bDMARDs treatment did not differ to a statistically significant extent, regardless of the presence of depression. Although the differences in the serum levels of OXT were observed prior to the initiation of treatment, there was no gender difference after treatment. Conclusion Although RA complicated by depression may be related to the following high disease activity, a poor QOL and poor ADLs, the serum OXT levels were not directly correlated.

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“…The same authors specified that oxytocin production is decreased in children with callous and unemotional traits. Sasaki et al did not find any associations between oxytocin concentration in saliva and the expressiveness of depression symptoms in adolescents, though patients with treatment-resistant depression showed higher levels of oxytocin than the control cohort with non-resistant depression [45]. The oxytocin plasma level was decreased in children with attention deficit/hyperactivity syndrome, and it was negatively correlated to impulsivity and inattentiveness [46,47].…”

Section: Pathogenesis Of Internet Addiction In Terms Of Neurobiologymentioning

confidence: 99%

Neurobiological Risk Factors for the Development of Internet Addiction in Adolescents

Tereshchenko

Каспаров

2019

Behavioral Sciences

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The sudden appearance and spread of Internet addiction in adolescent populations, in association with the rapid escalation of consumed Internet content and the broad availability of smartphones and tablets with Internet access, is posing a new challenge for classical addictology which requires urgent solutions. Like the majority of other psychopathological conditions, pathological Internet addiction depends upon a group of multifactor polygenic conditions. For each specific case, there is a unique combination of inherited characteristics (nervous tissue structure, secretion, degradation, and reception of neuromediators), and many are extra-environment factors (family-related, social, and ethnic-cultural). One of the main challenges in the development of the bio-psychosocial model of Internet addiction is to determine which genes and neuromediators are responsible for increased addiction susceptibility. This information will herald the start of a search for new therapeutic targets and the development of early prevention strategies, including the assessment of genetic risk levels. This review summarizes the literature and currently available knowledge related to neurobiological risk factors regarding Internet addiction in adolescents. Genetic, neurochemical and neuroimaging data are presented with links to actual pathogenetic hypotheses according to the bio-psychosocial model of IA forming.

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Increased Serum Levels of Oxytocin in ‘Treatment Resistant Depression in Adolescents (TRDIA)’ Group

Cited by 25 publications

References 25 publications

Prosocial Behavior and Depression: a Case for Developmental Gender Differences

Prosocial Behavior and Depression: a Case for Developmental Gender Differences

The Relationship between the Serum Oxytocin Levels, Disease Activity, the ADLs and the QOL in Patients with Rheumatoid Arthritis

Neurobiological Risk Factors for the Development of Internet Addiction in Adolescents

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