Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome

Gururajan, Priya; Gurumurthy, Prema; Nayar, Pradeep G; Babu, Sai; Sarasabharati, A.; Victor, Dolice; Cherian, K.M.

doi:10.1007/s12291-009-0043-9

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…The optimum cutoff value above which diagnosis of UA was confirmed for sCD40L was 2.15 ng/ml . This is consistent with the findings of Gururajan et al (2009) where the optimum cut off value from the ROC curve was 2.99 ng/ml, above which sCD40L was considered to be positive. Comparison of the area under the curve for Troponin I, CK-MB and sCD40L, reveals the fact that sCD40L may alone serve as a good discriminator of patients with ACS on comparison with gold standards.…”

Section: Discussionsupporting

confidence: 91%

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Evaluation of Soluble Serum cd40 Ligand Level as a Significant Marker of Unstable Angina

2022

Al-Azhar University Journal of Virus Researches and Studies

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The CD40L on activated T cells and platelets may be activating matrix metalloproteinases, inducing procoagulant activity, and be involved in the pathogenesis of acute coronary syndrome (ACS) by promoting plaque rupture in atheroma [ . 1 ] The aim of this work is to assess soluble serum level CD40L to clarify its role in unstable angina (UA). This work included 70 patients suffered from UA who were admitted to coronary care unit (CCU) in National Heart Institute (NHI). All subjects included in the study were evaluated by history, clinical examination, ECG, Routine biochemical investigations, CK total, CK-MB, and Quantitative ELISA for sCD40L. The sCD40L levels were significantly elevated in patients with UA when compared to controls (4.05 ± 1.61 % vs. 1.42 ± 0.63 %, P< 0.001). In multivariate logistic regression analysis, only sCD40L & FBS were efficient as predictors of UA with optimum cutoff value for diagnosis of UA was 2.15 .% Enhanced levels of sCD40L in angina patients, particularly in patients with UA, suggests that CD40L-CD40 interaction may play a role in both the long-term atherosclerotic process and in the triggering of ACS.

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Section: Discussionsupporting

confidence: 91%

“…Combined analysis of sCD40L, Troponin I and CK-MB may enhance risk prediction for cardiovascular events. [17]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Soluble Serum cd40 Ligand Level as a Significant Marker of Unstable Angina

2022

Al-Azhar University Journal of Virus Researches and Studies

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“…These events may further contribute to endothelium injury and accompanying atherogenesis. sCD40L may play a pathogenic role in triggering acute coronary syndromes [ 54 , 62 ]. The involvement of CD40-CD154 interactions in autoimmunity and allo-immunity is also well documented.…”

Section: What Is the Function Of Cd40l?mentioning

confidence: 99%

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

Aloui

Prigent

Sut

et al. 2014

IJMS

140

116

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The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including CD40. This interaction is necessary for the antigen specific immune response. Furthermore, CD40L and sCD40L are involved in inflammation and a panoply of immune related and vascular pathologies. Soluble CD40L is primarily produced by platelets after activation, degranulation and cleavage, which may present a problem for transfusion. Soluble CD40L is involved in adverse transfusion events including transfusion related acute lung injury (TRALI). Although platelet storage designed for transfusion occurs in sterile conditions, platelets are activated and release sCD40L without known agonists. Recently, proteomic studies identified signaling pathways activated in platelet concentrates. Soluble CD40L is a good candidate for platelet activation in an auto-amplification loop. In this review, we describe the immunomodulatory role of CD40L in physiological and pathological conditions. We will focus on the main signaling pathways activated by CD40L after binding to its different receptors.

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“…The soluble ligand of this marker, sCD40L, can also be found in the form of a transmembrane protein and elevated sCD40L levels can also be indicative of an increased risk of CVD. 42 Exacerbation of the inflammation increases the instability of atherosclerotic plaques, increasing vulnerability to recurrent coronary events. This instability leads to obstruction of small vascular compartments or even to formation of thrombi, which in turn can lead to more severe obstructions.…”

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confidence: 99%

Síndrome metabólica, aterosclerose e inflamação: tríade indissociável?

et al. 2015

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Populations all over the world are increasingly inactive and are consuming increasing quantities of fats and sugars, which is generally linked to industrially processed foods. The consequences have rapidly manifest as an increase in overweight/obesity and in physiological and metabolic changes, such as the Metabolic Syndrome, which is a series of changes in glycemia, lipids and blood pressure. There is evidence of a close relationship between these changes and inflammatory processes, which can also be linked to oxidative stress. These conditions lead to the pathogenesis of vascular abnormalities or intensify metabolic processes that accompany the metabolic syndrome. The objective of this review is to compare the large number of bibliographic references that show correlations between components of the Metabolic Syndrome and increases in the mediators of inflammation. The publications reviewed were located using the Pubmed, Scopus, Lilacs and Scielo databases and the majority of the articles selected were published within the last 5 years.Keywords: metabolic syndrome ; arteriosclerosis; inflammation. ResumoObserva-se, nas populações mundiais, aumento do sedentarismo e aumento do consumo de gorduras e açúcares, sendo estes vinculados normalmente aos alimentos industrializados. A consequência disso rapidamente se manifestou no aumento do sobrepeso/obesidade e na instalação de alterações fisiológicas e metabólicas, como a Síndrome Metabólica, que é representada por alterações na glicemia, nos lipídeos e na pressão arterial. Há evidências de ligação estreita entre estas alterações e os processos inflamatórios, que também podem estar associados ao estresse oxidativo. Estas condições levam à patogênese das alterações vasculares ou intensificam os processos metabólicos que acompanham a Síndrome Metabólica. O objetivo desta revisão foi comparar as inúmeras referências literárias que mostram correlação entre os componentes da Síndrome Metabólica e o aumento dos mediadores de inflamação. Para isso, utilizou-se Pubmed, Scopus, Lilacs e Scielo como base de dados, sendo que os artigos selecionados dataram principalmente dos últimos cinco anos.Palavras-chave: síndrome metabólica; arteriosclerose; inflamação.

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Increased serum concentrations of Soluble CD40 Ligand as a prognostic marker in patients with Acute Coronary Syndrome

Cited by 8 publications

References 18 publications

Evaluation of Soluble Serum cd40 Ligand Level as a Significant Marker of Unstable Angina

Evaluation of Soluble Serum cd40 Ligand Level as a Significant Marker of Unstable Angina

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

Síndrome metabólica, aterosclerose e inflamação: tríade indissociável?

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