Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma. Clinical and prognostic implications

Wasik, Mariusz A.

doi:10.1001/archderm.132.1.42

Cited by 47 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with this finding, elevated IL-2 receptor expression has been reported to correlate well with disease states as it is highly increased in advanced CTCL as reported previously. 43,44 Interestingly, our studies revealed that AHI-1 transcript levels were elevated in CD4 þ CD7 À cells from patients with typical SS (SS-2 group); this elevation is not found in similarly purified normal T-cell from healthy individuals or in atypical patients with a low content of leukemic Sezary cells. The highest expression of AHI-1 occurred in a patient (No.…”

Section: Discussionmentioning

confidence: 69%

Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas

et al. 2006

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 69%

Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas

et al. 2006

View full text Add to dashboard Cite

“…The poor prognosis of Sézary patients whose circulating neoplastic T-cells express FoxP3 transcripts is a new finding that needs to be validated on fresh samples from a larger series of patients. If confirmed, then FoxP3 expression by neoplastic cells can be added to the list of other prognostic indicators for SS such as absolute Sézary cell count [46,47], serum level of lactate dehydrogenase [94,95] or soluble interleukin-2 receptor [96,97], and gene expression profile [37]. The gene expression profile of T-plastin, FoxP3 and other markers of T-cell activation in peripheral blood mononuclear cell samples from patients with Sézary syndrome compared with normal controls.…”

Section: Discussionmentioning

confidence: 99%

Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma

Capriotti

Vonderheid

Thoburn

et al. 2008

Leukemia & Lymphoma

View full text Add to dashboard Cite

Peripheral blood cells from 28 patients with leukemic cutaneous T-cell lymphoma including 25 patients with Sézary syndrome were evaluated for expression of regulatory T-cell-associated markers (FoxP3, CD25, CTLA-4, neurophilin-1), T-cell activation markers (CD28 and its ligands B7.1 and B7.2) and NK cell-associated markers (NKG2D and its ligands MicA and Mic-B) using real-time quantitative polymerase chain reaction. T-plastin served as a positive genetic marker, and its expression correlated to blood tumor burden. More than 90% of samples had transcripts for CD28 and Mic-B, but less than 30% of samples expressed FoxP3, CTLA-4 and CD25. Expression of Mic-B by neoplastic cells could provide another mechanism to inhibit anti-tumor immune responses. FoxP3 expression correlated with a poor prognosis. Although the underlying mechanisms accounting for this correlation remain unclear, the expression of the Foxp3 and CTLA-4 regulatory elements indicates that a subset of leukemic cases displays a regulatory T-cell phenotype.

show abstract

“…Laboratory findings can also be similar in CTCL and AD, such as eosinophilia, high serum levels of lactate dehydrogenase (LDH), immunoglobulin E (IgE), and soluble interleukin-2 receptor (sIL-2R; refs. [3][4][5]. Histologic appearance is the key to distinguish between these 2 diseases.…”

Section: Mycosis Fungoides (Mf) and Sezary Syndrome (Ss) Are The Mostmentioning

confidence: 99%

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

Miyagaki

Sugaya

Suga

et al. 2011

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: Both patients with cutaneous T-cell lymphoma (CTCL) and those with atopic dermatitis (AD) have pruritus, T H 2-biased T cells, and a tendency to have bacterial infections, suggesting a common pathologic basis for these two diseases. Recently, interleukin (IL)-22-producing T cells were reported in skin of patients with AD. In this study, we investigated expression levels of T H 22-and T H 17-related molecules in lesional skin and sera isolated from patients with CTCL.Experimental Design: Skin biopsies and sera were collected from patients with CTCL or psoriasis and from healthy volunteers. Protein and mRNA expression levels of IL-22, IL-17A, IL-17F, IL-23p19, IL-10, IL-4, CCL20, CCR6, IL-8, and IL-20 were examined in lesional tissue and a subset of these molecules in sera. Phosphorylation of STAT3 was also assessed in lesional skin of CTCL and psoriasis by immunohistochemistry.Results: IL-22, IL-10, IL-4, CCL20, and CCR6 mRNA and protein levels, but not IL-17A, IL-17F, IL-23p19, IL-8, or IL-20, were significantly elevated in lesional skin of CTCL. Phosphorylation of STAT3 was detected in epidermis of CTCL skin. Moreover, serum IL-22, IL-10, and CCL20 levels were increased in CTCL and correlated with disease severity.Conclusions: Our results suggest that IL-22 is important in establishing the tumor microenvironment for CTCL. Enhanced expression of CCL20 may explain epidermal hyperplasia and migration of CCR6 þ cells, such as Langerhans cells, into lesional skin. Relatively low expression of IL-17 may explain the lack of neutrophils in lesions of CTCL, which correlates with bacterial infections that commonly occur in skin affected by CTCL. Clin Cancer Res; 17(24); 7529-38. Ó2011 AACR.

show abstract

Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma. Clinical and prognostic implications

Cited by 47 publications

References 0 publications

Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas

Evidence for an oncogenic role of AHI-1 in Sezary syndrome, a leukemic variant of human cutaneous T-cell lymphomas

Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

Contact Info

Product

Resources

About