Increased serum concentration of the soluble interleukin-2 receptor in cutaneous T-cell lymphoma. Clinical and prognostic implications

Comprehensive serum cytokine analysis identifies IL-1RA and soluble IL-2Rα as predictors of event-free survival in T-cell lymphoma

“…Wang et al [25] demonstrated the importance of IL-10 on the microenvironment through promotion of alternative macrophage polarization. It has long been recognized that sIL-2R levels predicted inferior outcomes in CTCL [26,27] and studies of sIL-2R levels in TCL have also been consistent with our findings. sIL-2R elevations were predictive of an inferior outcome in a study of 36 AITL patients [28] and in a separate study of 30 patients with PTCL-NOS [29].…”

Increased CCL18 expression in patients with cutaneous T‐cell lymphoma: association with disease severity and prognosis

“…5). Based on the previous reports and our results, 29,36,37,40 serum CCL18 levels could be another disease marker for CTCL.…”

Elevated Serum CTACK/CCL27 Levels in CTCL

“…In this study, we showed that serum CTACK/CCL27 levels in patients with CTCL strongly correlated with types of skin lesions, TBI, serum soluble IL-2 receptor, and thymus and activationregulated chemokine/CCL17 levels, all of which are already reported to be good makers of disease activity (Wasik et al, 1996;Schmid et al, 1999;Kakinuma et al, 2003b). In addition, serum CTACK/CCL27 levels in patients with CTCL decreased after treatment.…”