Increased scalp skin and serum 5 alpha-reductase reduced androgens in a man relevant to the acquired progressive kinky hair disorder and developing androgenetic alopecia

Acquired Progressive Kinking of the Hair

“…Acquired progressive kinking of androgendependent hair associated with thinning. This type of APKH has until now been reported in 16 patients, including 9 patients in the literature [1][2][3][4]7 and our 7 patients. All reported patients were postpuberal males and developed androgenetic alopecia of the areas affected by hair kinking.…”

“…Since then fewer than 20 cases have been reported in the literature, [2][3][4][5][6][7][8][9][10][11][12][13][14] mainly as single case reports. The possibility that APKH could represent a clinical variety of androgenetic alopecia was first postulated by Mortimer and coauthors 3 in 1985 and recently supported in the article by Boudou and Reygagne,4 who showed pathological features consistent with the diagnosis of androgenetic alopecia as well as increased scalp concentrations of dihydrotestosterone in a patient affected by this condition. We report here the clinical and pathological features as well as the follow-up of 7 patients affected by APKH.…”

Acquired Progressive Kinking of the Hair: A Narrative Review of the Androgen‐Dependent Phenotype

“…Histopathological studies frequently demonstrate features suggestive of early AGA, including follicular miniaturization, reduced terminal‐to‐vellus hair ratios, and increased telogen counts [13]. Elevated scalp DHT levels and enhanced 5α‐reductase activity further support a shared androgenic mechanism [14]. Clinically, this link is relevant, as several longitudinal studies have documented the progression of APKH to overt AGA within a few years, despite therapeutic interventions such as topical minoxidil.…”

Hair Transplantation in Migraine Headache Patients

“… 23 , 40 , 41 The latter elements quantifiably differ in areas of alopecia and hair-bearing scalp. 23 , 40 – 43 Accordingly, occipital hairs maintain resistance to male androgens when transplanted to vertex, and scalp hairs transplanted from vertex to forearm regress at the same pace as donor site. 44 Both tissue destruction and genetic underpinnings may account for differences within receiver fields.…”