Increased risk of breast cancer in women with uterine myoma: a nationwide, population-based, case-control study

Tseng, Jen Yu; Chen, Yi Huei; Chiang, Hsiu‐Yin; Lin, Ching Heng

doi:10.3802/jgo.2017.28.e35

Cited by 11 publications

(15 citation statements)

References 15 publications

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“…The mutation status can inform them on whether they should operate on suspicious adnexal masses [8]. Breast cancer patients are at high risk for uterine myoma [3]. In our study, we found 5 adnexal masses and 6 uterine myoma patients.…”

Section: Discussionmentioning

confidence: 50%

“…Gynecologic and gynecologic oncology clinic visits and consultations related to breast cancer diagnosis and treatment are performed for many reasons, including common gynecologic problems presenting with dysmenorrhea, menstrual irregularity with or without uterine myoma, adnexal masses, infertility, menopausal symptoms, bone loss related to use of GnRH agonist, and endometrial cancer risk evaluation associated with tamoxifen use [3][4][5][6][7][8]. BRCA mutation patients have a lifetime risk of breast and ovary cancer.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Role of Gynecologic Oncologist as BRCA Mutation Counselor for Breast Cancer Patients

2019

Journal of Women’s Health and Gynecology

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Background: BRCA mutations carry a lifetime risk of breast and ovarian cancer. Although breast cancer occurs more frequently than ovarian cancer, it has lower mortality in Korea and the United states. Providing genetic counseling for BRCA mutation carriers provides several advantages in the prevention and treatment of both cancers. The objective of this study was to investigate the role of gynecologic oncologists as genetic counselors for BRCA mutation in breast cancer. Material & Methods:We performed a retrospective review of patients diagnosed with breast cancer who had visited a gynecologic oncology clinic for a variety of reasons. Clinical information of age, family and personal history of cancer, and purpose of clinic visit was extracted from their medical records. Genetic counseling of BRCA1 and 2 mutations was offered to any patient who had not undergone counseling previously. Risk management and further counseling were offered to inform patients about risk-reducing surgery and cascade testing of family members after obtaining results of such mutations.Outcomes: A total of 33 breast cancer patients who had visited a gynecologic clinic were selected. The most common purpose of visit was routine gynecological exam (16/33) and the second most common was gynecologic problems with fibroids, ovarian cysts, and vaginal spotting (15/33). Two patients visited for risk-reducing surgery consultation. Median ages at clinic visit and diagnosis of breast cancer were 46 (range, 32-69) and 44 (range, 32-69) years, respectively. Fourteen (14/33, 42%) patients were stage IA and three patients were triple negative (ER/PR/HER2/neu). Eighteen (18/33, 55%) patients were taking tamoxifen. Five patients had a family history of BRCA-related cancer. Among 33 patients, only three with BRCA results had BRCA counseling by a breast cancer surgeon and 11 (11/33, 37%) patients accepted BRCA gene testing. Two patients had BRCA1 germline mutations and two had BRCA2 mutations. Three patients had VUS (Variation of Unknown Mutation). Information about risk-reducing surgery and family counseling were provided for all patients who were positive for mutation.Conclusions: Genetic counseling about BRCA mutations in breast cancer patient by experienced gynecologic oncologists is feasible. Breast cancer patients with gynecologic issues are encouraged to receive genetic counseling by gynecologic oncologists.

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Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Emerging Role of Gynecologic Oncologist as BRCA Mutation Counselor for Breast Cancer Patients

2019

Journal of Women’s Health and Gynecology

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“…A population-based study by Wise et al, in the USA, failed to find any association between the history of UL diagnosis and the overall incidence of breast cancer [ 5 ]. Two Asian studies based in Taiwan showed a higher incidence of breast cancer in patients with UL without increased mortality [ 6 - 7 ].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Breast Carcinoma, Uterine Myoma, and Ovarian Teratoma in a Single Woman

Das¹,

Bramhachari²,

Halder³

et al. 2021

Cureus

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Multiple primary tumors in a patient diagnosed with invasive ductal breast cancer are rarely reported in the literature. Here we present a case of invasive ductal carcinoma of the breast in a 42-year-old lady, with synchronous uterine leiomyoma (UL), ovarian teratoma and with prior history of follicular adenoma of thyroid in the same patient. The clinical presentation and management plan is discussed with a review of the literature. Breast cancer is the most common cancer in women where the concomitant occurrence of multiple primary tumors is a diagnostic and therapeutic challenge. In low- and middle-income countries, where facilities of genetic screening in all patients of synchronous neoplasia are limited due to scarcity of resources, strong clinical suspicion, multidisciplinary management, and follow-up remain important.

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“…The primary exposure of interest in this study was uterine myoma, which was defined as women with a previous diagnosis of uterine myoma (ICD-9-CM 218 or 219.9) with at least three outpatient visits or one hospitalization within the year preceding the index date to increase the diagnosis accuracy. This method has been applied by our group in a previous study on uterine myoma [15]. Uterine myoma was diagnosed based on the patient's medical history, clinical features, bimanual palpation, and ultrasonography.…”

Section: Methodsmentioning

confidence: 99%

Prior uterine myoma and risk of ovarian cancer: a population-based case-control study

et al. 2019

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Objective Uterine myoma which results in the magnitude of ovarian cancer remains uncertain. This study aimed to assess the association between women with previous uterine myoma and the risk of ovarian cancer. Methods This population-based case-control study was conducted using the Taiwan National Health Insurance Research Database between 2006 and 2010. We identified 4,088 adult women with newly diagnosed ovarian cancer with 16,348 women without ovarian cancer matched for age, urbanization level, income and initial diagnosis date. Logistic regression analyses were used to evaluate the variables associated with ovarian cancer. In addition, the effect of surgical interventions on the risk of ovarian cancer was also evaluated. Results Women with previous uterine myoma were more likely than those who did not to have ovarian cancer (adjusted odds ratio [aOR]=2.26; 95% confidence interval [CI]=2.06−2.49). Patients with uterine myoma who either received (aOR=1.79; 95% CI=1.51−2.13) or did not receive hormone replacement therapy (aOR=2.51; 95% CI=2.24−2.82) experienced a significantly higher risk of ovarian cancer than those without uterine myoma, respectively. However, patients with uterine myoma who underwent either myomectomy (aOR=0.55; 95% CI=0.39−0.77) or hysterectomy (aOR=0.33; 95% CI=0.26−0.42) had a significantly lower risk of ovarian cancer. Conclusion The results revealed that a significantly higher risk of ovarian cancer in women with previous uterine myoma, through an indirect mechanism. Furthermore, a lower risk of ovarian cancer was observed in women who underwent surgical removal of the uterine myoma.

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Increased risk of breast cancer in women with uterine myoma: a nationwide, population-based, case-control study

Cited by 11 publications

References 15 publications

Emerging Role of Gynecologic Oncologist as BRCA Mutation Counselor for Breast Cancer Patients

Emerging Role of Gynecologic Oncologist as BRCA Mutation Counselor for Breast Cancer Patients

Synchronous Breast Carcinoma, Uterine Myoma, and Ovarian Teratoma in a Single Woman

Prior uterine myoma and risk of ovarian cancer: a population-based case-control study

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