Increased red cell distribution width in patients with slow coronary flow syndrome

Abstract

OBJECTIVE:An elevated red cell distribution width has been recognized as a predictor of various cardiovascular diseases. Slow coronary flow syndrome is an important angiographic clinical entity with an unknown etiology. This study aimed to examine the relationship between red cell distribution width and the presence of slow coronary flow syndrome.METHODS:In total, 185 patients with slow coronary flow syndrome and 183 age- and gender-matched subjects with normal coronary flow (controls) were prospectively enrolled in this study. Red cell distribution width and C-reactive protein were measured upon admission, and the results were compared between the patients with slow coronary flow syndrome and normal controls.RESULTS:Red cell distribution width levels were significantly higher in the patients with slow coronary flow syndrome than the normal controls. Moreover, the data showed that the plasma C-reactive protein levels were also higher in the patients with slow coronary flow syndrome than in the normal controls. In addition, a multivariate analysis indicated that C-reactive protein and red cell distribution width were the independent variables most strongly associated with slow coronary flow syndrome. Finally, the red cell distribution width was positively correlated with C-reactive protein and mean thrombosis in the myocardial infarction frame counts of the patients with slow coronary flow syndrome.CONCLUSION:The data demonstrated that red cell distribution width levels are significantly higher and strongly positively correlated with both C-reactive protein and thrombosis in the myocardial infarction frame counts of patients with slow coronary flow syndrome. These findings suggest that red cell distribution width may be a useful marker for patients with slow coronary flow syndrome.

An investigation of platelet parameters in smoking patients with coronary slow flow detected during coronary angiography

“…Cardiovascular diseases were associated with increased RDW [22]. A strong correlation was observed between RDW, which was reportedly linked with decreased coronary blood flow and inflammatory markers [23]. RDW levels were high in our study.…”

Increased red cell distribution width in patients with slow coronary flow

“…We read the article “Increased red cell distribution width (RDW) in patients with slow coronary flow (SCF) syndrome” by Luo et al (1). In this study, the authors examined the relationship between RDW and SCF syndrome.…”

Serum YKL-40 is increased in patients with slow coronary flow

“…Although the pathophysiological mechanism of SCF has not been determined consistently, several potential hypotheses have been suggested, such as an earlier form of atherosclerosis, platelet aggregability, the organic or functional dysfunction of small coronary arteries, and an imbalance between vasoconstricting and vasodilating factors [18,19]. Inflammation has been reported to be a major contributing factor in many cardiovascular events and is associated with different clinical settings of CAD, which may be involved in the development of SCF.…”