Increased pulmonary toxicity of ultrafine particles? II. Lung lavage studies

Oberdörster, Günter; Ferin, J; Finkelstein, Gleb; Wade, Patricia T.; Corson, Nancy

doi:10.1016/0021-8502(90)90065-6

Cited by 110 publications

(52 citation statements)

References 9 publications

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“…The pollutant gases containing DEPs were injected in the controlled atmosphere chamber. The penetration of particles in the respiratory system at normal speed induces deposition of the particle along the respiratory tract in agreement with studies reported by Oberdorster G et al (1990). Figure 3 shows the aspect of the control organ "Lung".…”

Section: Resultssupporting

confidence: 89%

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Air Pollution from Diesel Particles and Chronic Obstruction Pulmonary Disease - CT Scan Study

Mohammed

Amina²,

Guetaf

et al. 2017

ESJ

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Health problems have been observed in rabbits at low DEP concentration. The subject (animal) showed signs of chronic obstruction pulmonary disease (COPD). CT scan of the biopsy reveals significant emphysematous lesions. DEP grain causes inflammation of lung tissues around sites of deposition. Observations of tissue after formalin fixation reveal brown spots around the points of impact. It also reveals the double organic and inorganic aspect of DEPs. The organic compounds dissolve through slow diffusion in the lung physiological fluid while the inorganic part is partly handled by macrophages (phagocytosis).

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Section: Resultssupporting

confidence: 89%

“…The reaction with the alveolar epithelial cells is demonstrated; the ultrafine particle passes into the bloodstream. These physicochemical mechanisms may be responsible for cardiovascular and nervous diseases (Oberdorster et al 1990). …”

Section: Introductionmentioning

confidence: 99%

Air Pollution from Diesel Particles and Chronic Obstruction Pulmonary Disease - CT Scan Study

Mohammed

Amina²,

Guetaf

et al. 2017

ESJ

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“…The study of atmospheric aerosols especially in fine mode is gaining importance in scientific community as numerous studies have demonstrated their association with healthrelated (Pekkanen et al, 1997;Oberdorster et al, 1990;Laden et al, 2000) and climate change (Tegen et al, 1996;Ramanathan et al, 2001) issues. Further, the study of aerosol over Himalayan region is of paramount interest as the ecology of the Himalaya is under serious threat from various forms of pollutants (Bostrom, 2002).…”

Section: Introductionmentioning

confidence: 99%

Atmospheric Fine Mode Particulates at Eastern Himalaya, India: Role of Meteorology, Long-Range Transport and Local Anthropogenic Sources

Adak

Chatterjee

Singh

et al. 2014

Aerosol Air Qual. Res.

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A study on atmospheric fine (less than 2.0 µm) particulate matter was performed for the first time over the eastern Himalayas in India in order to investigate the formation and sources in two different seasons, pre-monsoon (Mar-May) and winter (Dec-Feb), for three consecutive years, 2008, 2009 and 2010. Fine mode aerosols were further segregated into three modes: ultrafine (less than 0.32 µm), superfine (0.32-1.0 µm) and fine (1.0-2.0 µm). The study was carried out at a high altitude hill station Darjeeling (2200 m asl) in the eastern Himalayas, India, using an aerosol spectrometer (GRIMM) to measure aerosol number concentrations. It was found that the ultrafine and superfine aerosol (less than 1.0 µm) concentrations were higher in the pre-monsoon period compared to winter, whereas the concentrations of fine mode aerosols were comparable during these two seasons. Meteorological conditions like sunny/non-cloudy days with higher radiative fluxes and lower humidity favored the formation of ultrafine aerosols from their precursor gases, and the initiation of this formation were observed during 0900-1000 hours LT. Superfine aerosols were mainly found to be aerosols transported from long distances during the pre-monsoon period, and showed peak levels during late morning till late afternoon. In contrast, higher concentrations were seen at night in winter. The fine mode aerosols were mainly locally generated anthropogenic aerosols, mostly emitted from vehicular sources during the pre-monsoon period, and from biomass burning during winter, with sharp diurnal peaks during morning and evening. The long-term study on size segregated aerosol concentrations carried out in this work is of considerable importance, and can be helpful for the validation of several regional and global aerosol models, and for other climate related studies that focus on the Himalayan region.

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“…For instance, particulate titanium dioxide (TiO 2 ) is classified as a nuisance dust and so is considered to have few adverse effects on the lung except at high exposure concentration. Neverthless, there are now reports showing that ultrafine titanium dioxide (Uf-TiO 2 ) with a diameter of 20 nm can induce a greater lung inflammatory reaction than 250 nm TiO 2 particles [7][8][9][10][11][12][13][14] . Uf-TiO 2 has been shown to enter the pulmonary interstitium and this may be a feature of the pathogenicity of ultrafine particles 15) .…”

mentioning

confidence: 99%

Comparative Toxicity of Standard Nickel and Ultrafine Nickel in Lung after Intratracheal Instillation

Zhang

Kusaka

Zhu

et al. 2003

Journal of Occupational Health

155

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Comparative Toxicity of Standard Nickel and Ultrafine Nickel in Lung after Intratracheal Instillation: Qunwei ZHANG, et al.; Department of Environmental Health, School of Medicine, FukuiMedical University-A comparison was made of the bronchoalveolar lavage fluid (BALF) response to ultrafine nickel (Uf-Ni) and standard-sized nickel (StdNi). Rats were intratracheally instilled with 0, 0.1, 0.5, 1 and 5 mg Uf-Ni and Std-Ni, respectively. At 3 d after instillation, the body weight and wet lung weight were determined. At the same time, BALF was analyzed for lactate dehydrogenase (LDH), total protein (TP), tumor necrosis factor-alpha (TNF-alpha), and total cell and differential cell counts. The results showed that indicators of lung injury and inflammation in BALF were markedly raised with increased Uf-Ni and Std-Ni for each from 0 to 1 mg, and there were no differences in the indices between instillation of Uf-Ni at 1 mg and 5 mg. The results also showed that the effects of Uf-Ni on the indices were significantly higher than those of Std-Ni. Additional groups of rats were intratracheally instilled with 1 mg of Uf-Ni or Std-Ni, and wet lung weight and BALF profiles were analyzed at 1, 3, 7, 15 and 30 d later. The effect of Uf-Ni and Std-Ni on indices that can be presumed to reflect epithelial injury and p e r m e a b i l i t y ( L D H o r T P ) , a n d r e l e a s e o f proinflammatory cytokine (TNF-alpha) were increased throughout the 30 d post-exposure and the effects of Uf-Ni on these indices were significantly higher than those of Std-Ni from 1 to 30 d after instillation. Moreover, the number of neutrophils and LDH activity in BALF of rats after exposure to Uf-Ni were significantly Received May 10, 2002; Accepted Oct 7, 2002 Correspondence to: Y. Kusaka, Department of Environmental Health, School of Medicine, Fukui Medical University, Matsuoka-cho, Fukui 910-1193 greater than those of Std-Ni-exposed rats up to 30 d after instillation. Our findings suggest that Uf-Ni has a much more toxic effect on the lung than St-Ni, but the mechanism remains to be elucidated. (J Occup Health 2003; 45: 23-30)

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Increased pulmonary toxicity of ultrafine particles? II. Lung lavage studies

Cited by 110 publications

References 9 publications

Air Pollution from Diesel Particles and Chronic Obstruction Pulmonary Disease - CT Scan Study

Air Pollution from Diesel Particles and Chronic Obstruction Pulmonary Disease - CT Scan Study

Atmospheric Fine Mode Particulates at Eastern Himalaya, India: Role of Meteorology, Long-Range Transport and Local Anthropogenic Sources

Comparative Toxicity of Standard Nickel and Ultrafine Nickel in Lung after Intratracheal Instillation

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