Increased preoperative C-reactive protein (CRP)-values without signs of an infection and complicated course after cardiopulmonary bypass (CPB) – operations

Boeken, Udo; Feindt, P.; Zimmermann, Norbert; Kalweit, G; Petzold, Thomas; Gams, E.

doi:10.1016/s1010-7940(98)00062-1

Cited by 43 publications

(39 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies demonstrated increased preoperative levels of CRP and adverse events [10]- [13]. In Agda Mezzomo et al study, similar variables were analyzed and were shown risk of mortality and readmission to hospital for cardiovascular reasons that related to high preoperative levels of CRP [14]. Whether measurement of plasma CRP level in patients undergo heart surgery is required for optimization of preoperative condition or not?…”

Section: Discussionmentioning

confidence: 99%

The Association between Preoperative Plasma C-Reactive Protein (CRP) Level and Postoperative Adult Heart Surgery Outcome

Bilehjani¹,

Fakhari²,

Farzin³

et al. 2016

OJIM

View full text Add to dashboard Cite

Introduction: Careful history and physical examinations are the best ways for preoperative evaluation. Currently, we are recommended to rely on doing them rather than unnecessary and costly laboratory tests for confirmation or diagnosis of disease. The aim of study is the survey of CRP level association to decide further evaluation and expert consultation, newly diagnosed problems and possible effect on postoperative mortality and morbidity. Methods and Materials: In a descriptive retrospective study, hospital documentation of 620 patients older than 18 years undergone heart surgery in Tabriz Shahid Madani hospital was evaluated. Addition to plasma CRP level, patient's demographic information, type of surgery, preoperative significant tests, delay time in surgery start time after anesthesiology visit, cause of requested specialty consultation and treatment recommendation, postoperative complications and mortality rate were recorded and analyzed. Patients were classified according to preoperative plasma CRP level to five groups as negative, +1, +2, +3 and not measured (i.e. they considered as normal (0 -5 mg/l), mildly (5 -40 mg/l), moderately (40 -200 mg/L) or severely increased (>200 mg/l) groups). Results: Of 620 patients, 402 were male and 218 were female. There was not statistically significant correlation among demographic variables (gender, age, weight, and height), heart disease diagnosis and the type of surgery in five groups. In 79 individuals, they were done specialty consultations that most common of them were neurology consultation because of impaired renal laboratory tests. Only 2 cases were due to high CRP level. In any of cases, this preoperative consultation didn't result from new disease cases. CRP plasma level hadn't association with preoperative red blood cell sedimentation level. Prevalence of preoperative acute myocardium infarction was higher in * Corresponding author. B. Eissa et al. 94patients with high CRP level. In group +1, delay time was lower than other groups. The most common causes were cardiac causes. There wasn't statistically significant correlation between CRP level and different postoperative complications. There wasn't significant association between ICU stay time and postoperative hospital stay time and plasma high CRP level. Conclusion: Probably, plasma CRP level increases before surgery in acute myocardial infarction and results in high mortality rate. It seems that routine measurement of CRP in candidates for heart operation is beneficial for mortality rate prediction, so its increasing level can't help to diagnosis newly cases and it isn't prudent to consult with specialist.

show abstract

Section: Discussionmentioning

confidence: 99%

The Association between Preoperative Plasma C-Reactive Protein (CRP) Level and Postoperative Adult Heart Surgery Outcome

Bilehjani¹,

Fakhari²,

Farzin³

et al. 2016

OJIM

View full text Add to dashboard Cite

show abstract

“…However, unlike in the setting of coronary artery disease or PCI, the reported predictive value of the preoperative CRP level for postoperative outcome in on-pump CABG has been controversial. 3,4,[11][12][13][14] Strong associations between an elevated hsCRP Values are mean ± SD. POD, postoperative day; WBC, white blood cell count; CK-MB, creatine kinase-MB; TnT, troponin T. Other abbreviation see in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…26 In support of the association between elevated preoperative hsCRP level and renal dysfunction, the preoperative inflammatory status as measured by the hsCRP level was closely associated with the postoperative inflammatory reaction and has been shown to magnify the effects of intraoperative inflammatory stressors. 13,14 Moreover, renal filtration contributes to the clearance of many inflammatory cytokines and thus postoperative renal dysfunction per se may also influence the course and magnitude of the inflammatory response, thereby effecting other major complications, including aggravation of the already present renal dysfunction. 27 Based on these perspectives and our results, therapeutic efforts should be made to attenuate the inflammatory response and/or to protect the kidney in patients with an elevated preoperative hsCRP level presenting for OPCAB.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive Value of C-Reactive Protein for Major Postoperative Complications Following Off-Pump Coronary Artery Bypass Surgery Prospective and Observational Trial

Kim

Shim

Hong

et al. 2009

Circ J

View full text Add to dashboard Cite

Background: To prospectively investigate the predictive value of the preoperative C-reactive protein (CRP) concentration for major postoperative complications following off-pump coronary artery bypass (OPCAB) surgery. Methods and Results: From January 2007 to December 2007, 185 consecutive patients scheduled for elective OPCAB surgery were allocated to a low-CRP group (n=137, CRP <0.3 mg/dl) and a high-CRP group (n=48, CRP ≥0.3 mg/dl). The incidence of major postoperative complications, defined as postoperative myocardial infarction, and 5 major morbidity endpoints including permanent stroke, renal dysfunction, any cardiac surgery reoperation, ventilation for more than 48 h, and deep sternal wound infection were assessed and compared. Multivariate logistic regression was used to determine the predictors of major postoperative complications. Patients in the high-CRP group had a significantly higher overall incidence of major postoperative complications, particularly renal dysfunction. In the multivariate logistic regression model, adjusting all the significant univariate predictors, baseline CRP >0.3 mg/dl and preoperative chronic renal failure (CRF) remained as significant independent predictors of major postoperative complications. Conclusions: Elevated preoperative CRP level and/or preoperative CRF indicate increased risk of developing major postoperative complications, particularly acute postoperative renal dysfunction in patients undergoing OPCAB surgery. (Circ J 2009; 73: 872 -877)

show abstract

“…Some studies have shown that increased preoperative levels of hsCRP are associated with adverse events after coronary artery bypass graft surgery [13][14][15][16] , whereas others do not find such association 17 . The main complications in the early postoperative period which are directly associated with increased preoperative levels of hsCRP are not clearly known.…”

Section: Introductionmentioning

confidence: 99%

Proteína C Reativa pré-operatória prediz infecção respiratória após cirurgia de revascularização miocárdica

Mezzomo¹,

Bodin²,

Lúcia³

2011

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

Increased preoperative C-reactive protein (CRP)-values without signs of an infection and complicated course after cardiopulmonary bypass (CPB) – operations

Cited by 43 publications

References 22 publications

The Association between Preoperative Plasma C-Reactive Protein (CRP) Level and Postoperative Adult Heart Surgery Outcome

The Association between Preoperative Plasma C-Reactive Protein (CRP) Level and Postoperative Adult Heart Surgery Outcome

Predictive Value of C-Reactive Protein for Major Postoperative Complications Following Off-Pump Coronary Artery Bypass Surgery Prospective and Observational Trial

Proteína C Reativa pré-operatória prediz infecção respiratória após cirurgia de revascularização miocárdica

Contact Info

Product

Resources

About