Increased plasma visfatin concentration is a marker of an atherogenic metabolic profile

Filippatos, Theodosios D.; Tsimihodimos, Vasilis; Derdemezis, Christos S.; Gazi, Irene F.; Saougos, Vasilios G.; Mikhailidis, DP; Tselepis, Alexandros D.; Elisaf, Moses

doi:10.1016/j.numecd.2011.07.002

Cited by 22 publications

(24 citation statements)

References 21 publications

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“…Additionally, the differences were significant in women, with only a tendency in men. These results are partially in contrast with a previously published study demonstrating similar visfatin/NAMPT levels among men and women [41]. Furthermore, it should be noted that most of the published studies assessed impact of obesity on circulating visfatin/NAMPT levels in women.…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, it should be noted that most of the published studies assessed impact of obesity on circulating visfatin/NAMPT levels in women. Moreover, in obese men, significantly lower visfatin/NAMPT levels compared to normal weight men were reported [20,41]. These discrepancies cannot be explained by the age differences between study populations themselves, but perhaps are a consequence of methodological aspects of visfatin/NAMPT assessment.…”

Section: Discussionmentioning

confidence: 97%

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Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

Olszanecka-Glinianowicz

Owczarek

Bożentowicz-Wikarek

et al. 2014

Metabolism

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

Olszanecka-Glinianowicz

Owczarek

Bożentowicz-Wikarek

et al. 2014

Metabolism

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“…The results of our study are suggestive of increased serum visfatin levels as an indicator of coronary artery disease (3,7,8,(13)(14)(15)(16)20,24,26,30,32,33,36) . The association has been first identified in patients with carotid artery disease (2,14) and results of different studies including visfatin and coronary artery disease have been published in recent years (7,15,26,27) .…”

Section: Discussionsupporting

confidence: 57%

“…Consequence ends up with cytokine-mediated and systemic inflammation and atherosclerosis. Various studies revealed association of visfatin with inflammation (14) , metabolic syndrome (6,15) , endothelial dysfunction (15) , atherosclerosis (8,15,16) and ischemia reperfusion injury (15)(16)(17)(18) .…”

Section: Introductionmentioning

confidence: 99%

Serum Visfatin Levels and Coronary Artery Disease

Gürsoy¹,

Duygu²,

Hökenek³

et al. 2014

Khj

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Introduction: Adipose tissue is not only source of energy but also an active endocrine organ serving function by secreting bioactive molecules called adipokines. Visfatin is a recently discovered adipokine and is proposed to play role in inflammatory and atherosclerotic states. We aimed to investigate the association of visfatin with coronary artery disease (CAD). Patients and Methods: Twenty patients undergoing coronary artery bypass grafting due to CAD were compared with 20 individuals without CAD angiographically. Gender, age, body mass index, and serum visfatin levels were compared between the two groups. Relationship of visfatin levels and severity of CAD, cross-clamp and cardiopulmonary bypass times were also investigated in the study group. Results: Age, gender, BMI, and blood pressures were not significantly different between the groups. There was significant difference in serum visfatin levels between the two groups (47.31±33.03 ng/mL and 9.04±7.18 ng/mL, p=0.0001). A strong correlation between the Gensini score and pre-operative visfatin levels (r=0.81; p=0.0001) was observed for the study group. No correlation was detected between the visfatin level and cardiopulmonary bypass and cross clamp times. Conclusion: Increased visfatin levels may be associated with inflammation and atherosclerotic cardiovascular diseases. Circulating visfatin level is increased in patients undergoing coronary artery bypass grafting. Further studies are warranted to determine the predictive value of serum visfatin as a biomarker and potential therapeutic target for metabolic and cardiovascular diseases. Key Words: Adipose tissue; adipokine; visfatin; atherosclerosis; coronary artery disease Giriş: Yağ dokusu yalnızca enerji kaynağı olmayıp aynı zamanda adipokin olarak adlandırılan biyoaktif maddeleri salgılayan bir endokrin organdır. Visfatin son dönemlerde keşfedilen, inflamasyon ve ateroskleroz ile ilişkilendirilen bir adipokindir. Bu çalışmada visfatinin koroner arter hastalığı ile ilişkisini araştırmayı amaçladık. Hastalar ve Yöntem: Koroner arter hastalığı sebebiyle koroner arter baypas greftleme planlanan 20 hasta anjiografik olarak koroner arter hastalığı olmayan 20 bireyle kıyaslandı. Cinsiyet, yaş, vücut kitle indeksi ve serum visfatin seviyesi gruplar arasında karşılaştırıldı. Visfatin seviyesinin koroner arter hastalığının ciddiyeti, aortic kros klemp zamanı ve kardiyopulmoner baypas zamanı ile ilişkisi de incelendi. Bulgular: Gruplar arasında yaş, cinsiyet, vücut kitle indeksi ve kan basınçları arasında fark saptanmadı. Serum visfatin seviyeleriyse anlamlı farklı bulundu (47,31±33,03 ng/ml ve 9,04±7,18 ng/ml, p=0,0001). Gensini skoru ile preoperative visfatin seviyesi arasında güçlü korelasyon saptandı (r=0,81; p=0,0001). Visfatin seviyesi ile kardiyopulmoner baypas ve aortic kros klemp zamanı arasında ilişki saptanmadı. Sonuç: Artmış serum visfatin seviyesi inflamasyon ve aterosklerotik kardiyovasküler hastalıklarla ilişkili olabilir. Dolaşımdaki visfatin seviyesi koroner arter baypas greftleme yapılan hastalarda...

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“…Adipose tissues are sources of energy as well as the hormone leptin (Zhang et al, 1994;Bountouris et al, 2009). Previous studies (Fried et al, 1998;Blüher, 2013) have indicated that adipokines, which are signaling proteins secreted by the adipose tissue and visceral fat, perform versatile regulatory functions during the various stages of multiple diseases including obesity, diabetes, inflammation (Moschen et al, 2007), metabolic disorders (Dahl et al, 2007;Shaker et al, 2011), endothelial dysfunction (Dahl et al, 2007;Filippatos et al, 2010Filippatos et al, , 2013, atherosclerosis, hypertension, and ischemic reperfusion injury (Karaduman et al, 2006;Dahl et al, 2007;Tousoulis et al, 2008;Filippatos et al, 2013). However, the role of visfatin in these diseases may be pleiotropic.…”

Section: Introductionmentioning

confidence: 99%

Correlation between polymorphisms in the visfatin gene and its expression in the serum and coronary artery calcification

Jin¹,

Sb²,

Zh³

et al. 2016

Genet. Mol. Res.

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Increased plasma visfatin concentration is a marker of an atherogenic metabolic profile

Cited by 22 publications

References 21 publications

Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

Serum Visfatin Levels and Coronary Artery Disease

Correlation between polymorphisms in the visfatin gene and its expression in the serum and coronary artery calcification

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