2004
DOI: 10.1016/j.exger.2004.07.007
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Increased plasma levels of soluble CD40, together with the decrease of TGFβ1, as possible differential markers of Alzheimer disease

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Cited by 72 publications
(52 citation statements)
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“…Deregulation of TGF-␤ signaling has been associated with a broad spectrum of behavioral abnormalities, including cognitive impairment, affective disorders, and deficits in sensorimotor gating (Vivien and Ali, 2006;Graciarena et al, 2010;Sun et al, 2010;Krieglstein et al, 2011). Our data showing that A␤Os decrease the levels of TGF-␤1 in vitro and in vivo are in agreement with the observation that TGF-␤1 levels are reduced in the plasma of AD patients, which might contribute to neuronal death and exacerbation of the neuroinflammatory process (Mocali et al, 2004;Juraskova et al, 2010). Additionally, deficiency in TGF-␤1 signaling, including reduced expression of neuronal T␤RII and Smad3 and defects in subcellular localization and nuclear translocation of phosphorylated Smad2/3 (von Bernhardi et al, 2015), has been reported in postmortem AD brain and in AD animal models and aged mice Tesseur et al, 2006;Ueberham et al, 2006;Chalmers and Love, 2007;Tichauer et al, 2014;Caraci et al, 2015).…”
Section: Discussionsupporting
confidence: 81%
See 1 more Smart Citation
“…Deregulation of TGF-␤ signaling has been associated with a broad spectrum of behavioral abnormalities, including cognitive impairment, affective disorders, and deficits in sensorimotor gating (Vivien and Ali, 2006;Graciarena et al, 2010;Sun et al, 2010;Krieglstein et al, 2011). Our data showing that A␤Os decrease the levels of TGF-␤1 in vitro and in vivo are in agreement with the observation that TGF-␤1 levels are reduced in the plasma of AD patients, which might contribute to neuronal death and exacerbation of the neuroinflammatory process (Mocali et al, 2004;Juraskova et al, 2010). Additionally, deficiency in TGF-␤1 signaling, including reduced expression of neuronal T␤RII and Smad3 and defects in subcellular localization and nuclear translocation of phosphorylated Smad2/3 (von Bernhardi et al, 2015), has been reported in postmortem AD brain and in AD animal models and aged mice Tesseur et al, 2006;Ueberham et al, 2006;Chalmers and Love, 2007;Tichauer et al, 2014;Caraci et al, 2015).…”
Section: Discussionsupporting
confidence: 81%
“…TGF-␤1 levels are reduced in the plasma of AD patients, which might contribute to neuronal death and exacerbation of neuroinflammation (Mocali et al, 2004;Juraskova et al, 2010). Additionally, deficits in TGF-␤ pathways have been reported in AD brains, in the brains of aged mice, and in mouse models of AD Tesseur et al, 2006;Ueberham et al, 2006;Chalmers and Love, 2007;Tichauer et al, 2014;Caraci et al, 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Such clinical criteria do not allow early diagnosis of Alzheimer's disease even if the pathological alterations are present years before a certain diagnosis. The availability of reliable minimallyinvasive biomarkers for AD progression and especially for incipient AD would be vital for an early diagnosis and a timely start of appropriate treatment to slow disease progression (Schupf et al, 2008;Mocali et al, 2004;Uberti et al, 2010;Padovani et al, 2001).…”
Section: Discussionmentioning
confidence: 99%
“…Blasko et al, 2006;Zetterberg et al, 2003;Malaguarnera et al, 2006;Rodriguez et al, 2007;Mocali et al, 2004;de Servi et al, 2002 Insulin- Abbreviations: AD, Alzheimers disease; CSF, cerebrospinal fluid; FTLD, frontotemporal lobe dementia; P, plasma; S, serum. Note that sometimes the same biomarkers has been found to be increased or decreased or unchanged reflecting the heterogenity of the disease.…”
Section: Discussionmentioning
confidence: 99%