Increased plasma levels of angiogenin and the risk of bladder carcinoma

Abstract

BACKGROUNDAngiogenesis is a well known prerequisite for tumor growth and metastasis. It is believed that angiogenin initiates cell migration and aids cell proliferation. Based on this, the authors hypothesized that individuals who had increased plasma levels of angiogenin were at an elevated risk for carcinoma of the urinary bladder.METHODSIn this ongoing case–control study, the authors used an enzyme‐linked immunosorbent assay to compare plasma levels of angiogenin in 209 patients with bladder carcinoma and in 208 healthy control participants who were matched according to age (± 5 years), gender, and ethnicity.RESULTSThe mean plasma angiogenin concentration was significantly higher in patients compared with controls (343.2 ng/mL vs. 308.0 ng/mL, respectively; P < 0.01). High plasma angiogenin levels were associated with a two‐fold increased risk for bladder carcinoma. Moreover, in patients who had superficial bladder carcinoma, plasma angiogenin levels were significantly higher among those who had recurrent disease than in those who were without recurrence (P < 0.01). Similarly, patients who had superficial bladder carcinoma with higher angiogenin levels had a shorter recurrence‐free survival than patients who had lower angiogenin levels (P < 0.01). Finally, elevated angiogenin levels were associated with an increased recurrence risk, with hazard ratio of 2.85.CONCLUSIONSThe results of this study demonstrated that the plasma levels of angiogenin were significantly higher in patients who had bladder carcinoma compared with healthy control participants and in patients with superficial bladder carcinoma who had recurrent disease compared with patients who were without recurrence. Therefore, an elevated plasma level of angiogenin may serve as a novel predictor for the risk of bladder carcinoma. Cancer 2005. © 2005 American Cancer Society.

The Kinetic Change of the Serum Angiogenin Level in Patients with Acute Cerebral Infarction

“…It is expressed in a wide variety of human cells [9]. ANG can be upregulated by a tumor, ischemia, or acute inflammatory reaction [8, 10, 11] and has been reported to be a potent stimulator of angiogenesis [1]. The relationship between angiogenesis and cerebral infarction has recently been drawing researchers’ attention.…”

“…ANG is a single-chain basic protein that consists of 123 amino acids, with molecular weight of 14.4 kDa and isoelectric point of 9.5 [1, 8]. It is expressed in a wide variety of human cells [9].…”

Serum angiogenin levels predict treatment response in patients with stage IV melanoma

“…In contrast, serum angiogenin levels were not found to be high in patients with squamous cell carcinoma of the head and neck [7]. In patients treated for bladder carcinoma, increased plasma levels of angiogenin are shown to predict increased risk for recurrence [8].…”

Aptasensor for electrochemical sensing of angiogenin based on electrode modified by cationic polyelectrolyte-functionalized graphene/gold nanoparticles composites

“…To date, very few studies have been carried out on detection of angiogenin. At present, enzyme-linked immunosorbent assay (ELISA) is the most widely used immunoassay method in the detection of angiogenin (Zhao et al, 2005;Kishimoto et al, 2005). The fluorescence detection of angiogenin using molecular labels is generally used in most of the cases .…”