Increased Plasma Cortisol Levels in Ocular Hypertension

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…This was in contrast to our previous studies on plasma cortisol levels, which were done on outpatients. 2,4,6 In this study, there was no significant difference in baseline plasma cortisol levels at 0800-0900 hours between the normals and the OH plus POAG group. In our previous studies, we found significant differences in plasma total cortisol and free cortisol between normals and OH and POAG with plasma samples obtained before 1200 hours.…”

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…This was in contrast to our previous studies on plasma cortisol levels, which were done on outpatients. 2,4,6 In this study, there was no significant difference in baseline plasma cortisol levels at 0800-0900 hours between the normals and the OH plus POAG group. In our previous studies, we found significant differences in plasma total cortisol and free cortisol between normals and OH and POAG with plasma samples obtained before 1200 hours.…”

Decreased Plasma Cortisol in Response to Intramuscular ACTH in Ocular Hypertensives and Primary Open-angle Glaucomas

“…This was in contrast to our previous studies on plasma cortisol levels, which were done on outpatients with a much larger sample size. 2,4 In this study, there was no significant difference in baseline plasma cortisol levels at 08:00 to 09:00 hours between the normals and the OH plus POAG group. In our previous outpatient studies, we found significant differences in plasma cortisol before 12:00 hours.…”

“…We have previously determined that glaucomatous patients and OHs as outpatients have higher plasma cortisol compared with normals, especially during the midmorning hours. 2,4 One analogous explanation for the hyporesponsiveness found in our glaucomatous subjects is that this is due to a chronic excess level of plasma cortisol resulting in adrenal suppression. However, adrenal cortical hyporesponsiveness is usually not associated with increased endogenous plasma cortisol except in some cases of benign adrenal adenoma as the basis of Cushing syndrome.…”

Teledermatology to Support Self-Care in Chronic Spontaneous Urticaria

“…The environmental-based data could alert a patient to reconsider an action (eg, walking in a particular area) but the front camera of the smartphone could also be of utility. The sensors of this camera could be engaged automatically (eg, unlocking via retina scan) and have the ability to measure numerous features including intraocular pressure [ 15 ] and pupil dilation [ 16 ]. Both metrics correlate with elevated levels of plasma cortisol, which itself is a biomarker for stress and a potential trigger for CSU [ 17 ].…”

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…This was in contrast to our previous studies on plasma cortisol levels, which were done on outpatients. 2,4,6 In this study, there was no significant difference in baseline plasma cortisol levels at 0800-0900 hours between the normals and the OH plus POAG group. In our previous studies, we found significant differences in plasma total cortisol and free cortisol between normals and OH and POAG with plasma samples obtained before 1200 hours.…”

Decreased Plasma Cortisol in Response to Intramuscular ACTH in Ocular Hypertensives and Primary Open-angle Glaucomas

“…This was in contrast to our previous studies on plasma cortisol levels, which were done on outpatients with a much larger sample size. 2,4 In this study, there was no significant difference in baseline plasma cortisol levels at 08:00 to 09:00 hours between the normals and the OH plus POAG group. In our previous outpatient studies, we found significant differences in plasma cortisol before 12:00 hours.…”

“…We have previously determined that glaucomatous patients and OHs as outpatients have higher plasma cortisol compared with normals, especially during the midmorning hours. 2,4 One analogous explanation for the hyporesponsiveness found in our glaucomatous subjects is that this is due to a chronic excess level of plasma cortisol resulting in adrenal suppression. However, adrenal cortical hyporesponsiveness is usually not associated with increased endogenous plasma cortisol except in some cases of benign adrenal adenoma as the basis of Cushing syndrome.…”

Teledermatology to Support Self-Care in Chronic Spontaneous Urticaria

“…The environmental-based data could alert a patient to reconsider an action (eg, walking in a particular area) but the front camera of the smartphone could also be of utility. The sensors of this camera could be engaged automatically (eg, unlocking via retina scan) and have the ability to measure numerous features including intraocular pressure [ 15 ] and pupil dilation [ 16 ]. Both metrics correlate with elevated levels of plasma cortisol, which itself is a biomarker for stress and a potential trigger for CSU [ 17 ].…”

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…This was in contrast to our previous studies on plasma cortisol levels, which were done on outpatients. 2,4,6 In this study, there was no significant difference in baseline plasma cortisol levels at 0800-0900 hours between the normals and the OH plus POAG group. In our previous studies, we found significant differences in plasma total cortisol and free cortisol between normals and OH and POAG with plasma samples obtained before 1200 hours.…”

Decreased Plasma Cortisol in Response to Intramuscular ACTH in Ocular Hypertensives and Primary Open-angle Glaucomas

“…This was in contrast to our previous studies on plasma cortisol levels, which were done on outpatients with a much larger sample size. 2,4 In this study, there was no significant difference in baseline plasma cortisol levels at 08:00 to 09:00 hours between the normals and the OH plus POAG group. In our previous outpatient studies, we found significant differences in plasma cortisol before 12:00 hours.…”

“…We have previously determined that glaucomatous patients and OHs as outpatients have higher plasma cortisol compared with normals, especially during the midmorning hours. 2,4 One analogous explanation for the hyporesponsiveness found in our glaucomatous subjects is that this is due to a chronic excess level of plasma cortisol resulting in adrenal suppression. However, adrenal cortical hyporesponsiveness is usually not associated with increased endogenous plasma cortisol except in some cases of benign adrenal adenoma as the basis of Cushing syndrome.…”

Teledermatology to Support Self-Care in Chronic Spontaneous Urticaria

“…The environmental-based data could alert a patient to reconsider an action (eg, walking in a particular area) but the front camera of the smartphone could also be of utility. The sensors of this camera could be engaged automatically (eg, unlocking via retina scan) and have the ability to measure numerous features including intraocular pressure [ 15 ] and pupil dilation [ 16 ]. Both metrics correlate with elevated levels of plasma cortisol, which itself is a biomarker for stress and a potential trigger for CSU [ 17 ].…”