Increased placental apoptosis in intrauterine growth restriction

Smith, Stephen C.; Baker, Philip N.; Symonds, E. M.

doi:10.1016/s0002-9378(97)70081-4

Cited by 362 publications

(239 citation statements)

References 17 publications

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“…Previous studies have shown that placentas from pregnancies complicated by preeclampsia or IUGR show enhanced apoptosis as compared to placentas from normal pregnancies (Smith et al 1997b;DiFederico 1999;Allaire et al 2000). The role of apoptosis has also been demonstrated in trophoblasts under hypoxic conditions (Levy et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies that have focused on the role of apoptosis in placenta in relation to the pathophysiology of preeclampsia and IUGR (DiFederico et al 1999;Levy et al 2002). It is well known that placentas from women complicated with preeclampsia or IUGR show enhanced apoptosis as compared to placentas of normal pregnant women (Smith et al 1997b;Allaire et al 2000;Ishihara et al 2002). However, the molecular mechanisms leading to apoptosis are complex, and include an ever-expanding list of signaling molecules such as the bcl-2 family of genes, the caspase-3 and NF-κ B (Hetts 1998;Adams and Cory 1999).…”

Section: Placental Materialsmentioning

confidence: 99%

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Expression of Nuclear Factor-Kappa B and Placental Apoptosis in Pregnancies Complicated with Intrauterine Growth Restriction and Preeclampsia: An Immunohistochemical Study

Aban

Cinel

Arslan

et al. 2004

Tohoku J. Exp. Med.

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Preeclampsia affects 7-10% of all pregnancies, and is a major cause of maternal and fetal morbidity and mortality. Although enhanced apoptosis is well known in placentas with preeclampsia, the role of transcription factor nuclear factor-kappa B (NF-κ B) in the process is still being debated. In this work, we investigate the relationship between NF-κ B expression and trophoblastic cell apoptosis in pregnancies complicated with preeclampsia or intrauterine growth restriction (IUGR) by immunohistochemical analysis of NF-κ B and three apoptosis related markers: bcl-2, caspase-3, and M30 CytoDeath antibody that identifies early apoptotic changes in the cytoskeleton related to action of caspase. The study was conducted on placental samples from 19 preeclamptic, 5 IUGR-complicated and 10 normal pregnant women. The three conclusions from the statistical analysis of the data are obtained; (i) Significantly higher expression of NF-κ B in IUGR-complicated (p = 0.003) and preeclamptic placentas (p = 0.004) than the control placentas, (ii) significantly higher M30 index and caspase 3 expression in IUGR and preeclampsia placentas (p = 0.003), and (iii) decreased expression of bcl-2 in IUGR and preeclampsia placentas (p = 0.001). Based on these observations, we suggest that increased trophoblastic apoptosis is at least partially induced by NF-κ B and reduced bcl-2 expression. preeclampsia; IUGR; apoptosis; NF-κ B; bcl-2

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Section: Discussionmentioning

confidence: 99%

Section: Placental Materialsmentioning

confidence: 99%

Expression of Nuclear Factor-Kappa B and Placental Apoptosis in Pregnancies Complicated with Intrauterine Growth Restriction and Preeclampsia: An Immunohistochemical Study

Aban

Cinel

Arslan

et al. 2004

Tohoku J. Exp. Med.

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show abstract

“…But it is well known that the rate of placental apoptosis is altered in some pathological conditions like preeclampsia and intrauterine growth retardation (30,32,33). the molecular mechanisms leading to apoptosis are complex and include an ever-expanding list of signalling molecules such as the bcl-2 family of genes, the caspase-3 and nf-kB (11,13).…”

Section: Age Induced Apoptosis In Placental Tissue Explantsmentioning

confidence: 99%

Cytotoxic Effect of Advanced Glycation end Products

Boyanova¹,

Huppertz

2009

Biotechnology & Biotechnological Equipment

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“…An increased incidence of apoptosis has been found in the placentae of women whose pregnancies are complicated by intrauterine growth restriction (Smith et al 1997). The possibility of variant forms of apoptosis has arisen in disparate systems: the rat placentae and the intersegmental muscles of the hawkmoth (Schwartz, 1992).…”

Section: School Of Human Development University Of Nottingham Nottimentioning

confidence: 99%

Placental & Perinatal Physiology

1999

The Journal of Physiology

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Increased placental apoptosis in intrauterine growth restriction

Cited by 362 publications

References 17 publications

Expression of Nuclear Factor-Kappa B and Placental Apoptosis in Pregnancies Complicated with Intrauterine Growth Restriction and Preeclampsia: An Immunohistochemical Study

Expression of Nuclear Factor-Kappa B and Placental Apoptosis in Pregnancies Complicated with Intrauterine Growth Restriction and Preeclampsia: An Immunohistochemical Study

Cytotoxic Effect of Advanced Glycation end Products

Placental & Perinatal Physiology

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