Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats

Anstrom, Kristin K.; Miczek, Klaus A.; Budygin, Evgeny A.

doi:10.1016/j.neuroscience.2009.03.023

Cited by 213 publications

(184 citation statements)

References 71 publications

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“…It is thus possible that firing patterns composed of bursts followed by pauses mediate a different signal than isolated bursts associated with rewards. This is in accord with observations of increased burst firing with stressful stimuli (Moore et al, 2001;Anstrom and Woodward, 2005;Anstrom et al, 2009). In this context, our results indicate that the important signal in "spontaneous burst firing" may be the pauses between bursts.…”

Section: Transients Map Linearly Onto Receptor Occupancysupporting

confidence: 93%

Influence of Phasic and Tonic Dopamine Release on Receptor Activation

Dreyer¹,

Herrik²,

Berg³

et al. 2010

J. Neurosci.

348

347

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Section: Transients Map Linearly Onto Receptor Occupancysupporting

confidence: 93%

Influence of Phasic and Tonic Dopamine Release on Receptor Activation

Dreyer¹,

Herrik²,

Berg³

et al. 2010

J. Neurosci.

348

347

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“…Previous studies in resident-intruder tests have shown that DA and 5-HT Effect of encounter stimulation in isolated mice Y Ago et al systems are involved in aggressive and defeat behaviors during the encounter (Anstrom et al, 2009;Ferrari et al, 2003;Tidey and Miczek, 1996;van Erp and Miczek, 2000). It appears that the effects of the encounter in resident-intruder tests are related to both psychological and physical stress.…”

Section: Discussionmentioning

confidence: 95%

“…This suggests that interactions between the resident mouse and an intruder mouse are necessary for these increases in prefrontal DA and 5-HT in male isolation-reared mice. Previous studies have shown that prefrontal DA levels are higher during or after an aggressive encounter in both attacking and defending rats (Anstrom et al, 2009;Tidey and Miczek, 1996;van Erp and Miczek, 2000). Furthermore, exposure to tests of 'anxiety', such as the social interaction test, causes an increase in hippocampal 5-HT release in rats from the more anxious Wistar strain, but not in rats from the less anxious SpragueDawley strain (Rex et al, 2004).…”

Section: Effect Of Encounter Stimulation In Isolated Mice Y Ago Et Almentioning

confidence: 93%

“…In resident-intruder tests, van Erp and Miczek (2000) reported that encounters with the intruder increased prefrontal and accumbal DA and decreased cortical 5-HT levels in the resident aggressive rats. Anstrom et al (2009), using fast-scan cyclic voltammetry and multiunit recording techniques, reported that an aggressive encounter increases phasic DA transmission in the mesolimbic pathway in defeated rats. These neurochemical changes were observed both during and after the encounters, and it is likely that the changes are related to both psychological and physical stress.…”

Section: Introductionmentioning

confidence: 99%

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Role of Social Encounter-Induced Activation of Prefrontal Serotonergic Systems in the Abnormal Behaviors of Isolation-Reared Mice

Ago

Araki

Tanaka

et al. 2013

Neuropsychopharmacol

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Isolation-reared male rodents show abnormal behaviors such as hyperlocomotion, aggressive behaviors, deficits of prepulse inhibition, and depression-and anxiety-like behaviors, but the neurochemical mechanism for the effects of psychological stress in these animals is not fully understood. This study examined the effects of social interactions between isolation-reared mice and intruder mice on brain monoaminergic systems. A cage was divided into two compartments by a mesh partition to prevent direct physical interactions. The 20-min encounter with an intruder elicited a restless and hyperexcitable state (hyperactivity) in male, but not in female, isolationreared mice, whereas encounters with a sleeping intruder or a novel object did not. Although the encounter did not affect prefrontal neuronal-activity-marker c-Fos expression, dopamine (DA) levels, or serotonin (5-HT) levels in male group-reared mice or female isolation-reared mice, it increased prefrontal c-Fos expression, DA levels, and 5-HT levels in male isolation-reared mice. Furthermore, encounter-induced increases in c-Fos expression in the dorsal raphe nucleus and ventral tegmental area, but not in the nucleus accumbens shell, were much greater in isolation-reared than group-reared male mice. A 5-HT 1A receptor agonist, a metabotropic glutamate 2/3 receptor agonist, and a gamma-aminobutyric acid A receptor agonist attenuated isolation-induced aggressive behaviors and encounter-induced hyperactivity, c-Fos expression in the prefrontal cortex and dorsal raphe nucleus, and increases in prefrontal 5-HT levels. These findings suggest that the prefrontal DA and 5-HT systems are activated by encounter stimulation in male isolationreared mice, and the encounter-induced activation of 5-HT system triggers the induction of some abnormal behaviors in male isolation-reared mice. Furthermore, this study implies that the encounter stimulation-induced signal has a pharmacological significance.

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“…Discrete aversive stimuli evoke pauses in the firing rate of a clear majority of dopamine neurons (Cohen et al, 2012;Matsumoto and Hikosaka, 2009;Mirenowicz and Schultz, 1996) and suppress phasic dopamine release in the NAc (Badrinarayan et al, 2012;Oleson et al, 2012;Roitman et al, 2008;Wheeler et al, 2011; but also see Anstrom et al, 2009;Brischoux et al, 2009;Budygin et al, 2012;Park et al, 2015 for reported increases in phasic dopamine activity to aversive stimuli under some conditions). However, while discrete stimuli are commonly used to study phasic dopamine responses, the time domain of aversive stimuli can range from discrete to prolonged.…”

Section: Introductionmentioning

confidence: 99%

The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors

Fortin

Chartoff

Roitman

2015

Neuropsychopharmacol

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Unconditioned rewarding stimuli evoke phasic increases in dopamine concentration in the nucleus accumbens (NAc) while discrete aversive stimuli elicit pauses in dopamine neuron firing and reductions in NAc dopamine concentration. The unconditioned effects of more prolonged aversive states on dopamine release dynamics are not well understood and are investigated here using the malaise-inducing agent lithium chloride (LiCl). We used fast-scan cyclic voltammetry to measure phasic increases in NAc dopamine resulting from electrical stimulation of dopamine cell bodies in the ventral tegmental area (VTA). Systemic LiCl injection reduced electrically evoked dopamine release in the NAc of both anesthetized and awake rats. As some behavioral effects of LiCl appear to be mediated through glucagon-like peptide-1 receptor (GLP-1R) activation, we hypothesized that the suppression of phasic dopamine by LiCl is GLP-1R dependent. Indeed, peripheral pretreatment with the GLP-1R antagonist exendin-9 (Ex-9) potently attenuated the LiCl-induced suppression of dopamine. Pretreatment with Ex-9 did not, however, affect the suppression of phasic dopamine release by the kappa-opioid receptor agonist, salvinorin A, supporting a selective effect of GLP-1R stimulation in LiCl-induced dopamine suppression. By delivering Ex-9 to either the lateral or fourth ventricle, we highlight a population of central GLP-1 receptors rostral to the hindbrain that are involved in the LiClmediated suppression of NAc dopamine release. Neuropsychopharmacology (2016) 41, 906-915;

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Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats

Cited by 213 publications

References 71 publications

Influence of Phasic and Tonic Dopamine Release on Receptor Activation

Influence of Phasic and Tonic Dopamine Release on Receptor Activation

Role of Social Encounter-Induced Activation of Prefrontal Serotonergic Systems in the Abnormal Behaviors of Isolation-Reared Mice

The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors

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