Increased oxidative stress in normal-weight postmenopausal women with metabolic syndrome compared with metabolically healthy overweight/obese individuals

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

“…Most notably, distinct fat distribution patterns (with less ectopic and visceral fat), and favorable inflammatory profiles (with lower concentrations of inflammatory markers) are seen with MHO [48]. Furthermore, in another study, MHO women had lower blood pressure, triglycerides, and glucose but higher HDL cholesterol, adiponectin and LDL size than MUHNW women [6]. Phillips et al found that MHO patients had lower levels of complement component 3, TNF-a, IL-6 and CRP, as well as a reduced white blood cell count and higher adiponectin [49].…”

“…Another study has shown that MUHNW participants have worse cardiovascular outcomes than MHO including higher levels of fatty liver and of subclinical systolic and diastolic dysfunction, suggesting that these outcomes are not dependent on BMI but rather on overall metabolic health [62]. MUHNW women have been shown to have increased risk for cardiovascular disease with higher blood pressure, triglycerides and glucose as well as lower adiponectin, HDL, and LDL size than MHO women [6]. MONW has also been shown to be associated with angiographic coronary artery disease after controlling for potential confounders [8].…”

Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study

“…3 Although it is generally accepted that the main pathogenic mechanism underlying the metabolic changes in patients with MetS relies on insulin resistance, there is evidence to indicate that a state of chronic low-level inflammation and oxidative stress (OxS) demonstrates a close link to MetS. 4, 5, 6, 7 …”

Hyperinsulinemia and Insulin Resistance: Scope of the Problem

“…34,35 Body weight is an unreliable indicator of current health and future disease risk, as normal-weight metabolic syndrome patients are at greater risk for morbidity and mortality than overweight individuals free of metabolic derangement. 36,37 For too long, overweight and obesity have been considered primary drivers of diabetes, heart disease, inflammatory disorders, etc., despite the fact that there are millions of normal-weight individuals who experience these conditions.…”