Increased oxidative stress and hypozincemia in male obesity

Özata, Metịn; Mergen, Mehmet; Öktenli, Çağatay; Aydın, Ahmet; Sanisoğlu, S. Yavuz; Bolu, Erol; Yılmaz, Mahmut İlker; Sayal, Ahmet; Işimer, A.; Ozdemír, I. Caglayan

doi:10.1016/s0009-9120(02)00363-6

Cited by 278 publications

(220 citation statements)

References 22 publications

Supporting

Mentioning

187

Contrasting

Unclassified

Order By: Relevance

“…Our previous finding also showed Jinhua had higher antioxidant enzymes activity than Landrace pigs in muscle (Guo et al, 2011). This result is different with the results of plasma antioxidants activity between obesity and healthy humans (Ozata et al, 2002;Chrysohoou et al, 2007). The greater antioxidant capacity in Jinhua pigs may be caused by pig genotype.…”

Section: Discussioncontrasting

confidence: 59%

See 1 more Smart Citation

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Ren

Shan

Zhu

et al. 2013

Animal

View full text Add to dashboard Cite

Sirtuins, NAD-dependent histone deacetylase (HDAC), are correlated to aging and antioxidant. The aim of this study was to determine breed differences of porcine Sirtuins expression and antioxidant capacity in brain between Jinhua pigs (a fatty breed of China) and Danish Landrace pigs (a leaner breed). Effect of age on Sirtuins' expression was also investigated. At the age of 180 days, the mRNA levels of Sirt1, as well as Sirt2 and Sirt4, in Jinhua pigs were greater, but the mRNA levels of Sirt3, Sirt5, Sirt6, and Sirt7 of Jinhua pigs were lower compared with Danish Landrace pigs. Likewise, at the same BW of 64 kg, the mRNA levels of Sirtuins, except Sirt5 and Sirt7, in Jinhua pigs were greater than Danish Landrace pigs. Meanwhile, Jinhua pigs possessed higher antioxidants activity than Danish Landrace pigs either at the same age or at the same BW. Furthermore, mRNA levels of Sirtuins were decreased with age in brain of the two breeds from 30 to 120 days. The results indicated that Sirtuins expression in brain was different between fatty and lean pigs, and Sirtuins expression may be correlated to antioxidant capacity. In addition, age could down-regulate Siruins expression in porcine brain.

show abstract

Section: Discussioncontrasting

confidence: 59%

“…Results showed that the total antioxidant capacity (T-AOC) in plasma is different between obese and healthy people (Ozata et al, 2002;Chrysohoou et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Ren

Shan

Zhu

et al. 2013

Animal

View full text Add to dashboard Cite

show abstract

“…11,12 On the other hand, several investigators have shown that the levels of lipid peroxidation products were elevated in various tissues including blood in obesity. [36][37][38][39] It has been previously reported that transport systems for glutathione S-conjugates play significant roles in the biotransformation of toxic products arising from oxidative stress-induced lipid peroxidation, as well as various GSH S-conjugate with/which has mutagenic and carcinogenic activities. 16,17 Thus, it is of interest to see how glutathione conjugate transport in cells of obese can protect cells from CDNB-induced oxidative damage by exporting DNP-SG.…”

Section: Discussionmentioning

confidence: 99%

Increased glutathione conjugate transport: a possible compensatory protection mechanism against oxidative stress in obesity?

et al. 2005

View full text Add to dashboard Cite

Objective: To compare glutathione S-conjugate transport in obese and nonobese persons, and how glutathione S-conjugates are involved in the antioxidant status in obesity. Materials and methods: The efflux of glutathione conjugates and malondialdehyde (MDA) levels were measured in erythrocytes of obese (N ¼ 33) and nonobese (N ¼ 28) persons at every 30 min during a 120 min incubation time in vitro. 2,4-dinitrophenyl-S-glutathione (DNP-SG) represented the glutathione S-conjugate. Results: The efflux of conjugate in erythrocytes from obese subjects (7087147 DNP-SG efflux nmol/ml erythrocytes/h) was significantly higher than that of control group (4907105 DNP-SG efflux nmol/ml erythrocytes/h) (Po0.05). At all time points measured (30-120 min), there was an increase in DNP-SG efflux in obese group (Po0.05). This is manifested by a decrease in cellular DNP-SG levels. The susceptibility of erythrocytes to in vitro 1-chloro-2,4-dinitrobenzene (CDNB)-induced oxidative stress were greater for cells of control group (Po0.05), although hemolysis sensitivity of these cells are not different between both groups (P40.05). Following CDNB pretreatment, incubation of erythrocyte with vanadate, a DNP-SG transport inhibitor, resulted in an increase of MDA in both groups. However, in this case, the difference in susceptibility was not related to obesity. On the other hand, while erythrocyte glutathione level was lower in obese subjects (79% of control) than in controls (Po0.05), the adenosine 5 0 -triphosphate (ATP) levels, the enzyme activities of glutathione S-transferase (GST) and the conjugation capacities of the erythrocytes were not different between groups (P40.05). Conclusion: Obesity may increase erythrocyte glutathione conjugate transport independent from ATP and GST activity that may protect against MDA formation in vitro.

show abstract

“…Alterations of TE metabolism could be involved in the oxidative stress of diabetes, such as of Fe: urine excretion of zinc (Zn) and Cr is increased. The activity of antioxidant enzymes, specifically GPx whose cofactor is Se, is decreased [10,16].…”

Section: Selenium Copper and Zincmentioning

confidence: 99%

Effects of trace elements and calcium on diabetes and obesity, and their complications: Protective effect of dairy products – A mini-review

Bouglé¹,

Bouhallab²,

Bureau³

et al. 2009

Dairy Sci. Technol.

View full text Add to dashboard Cite

-Trace elements and minerals influence the pathogenesis of obesity and diabetes and their complications, mainly through their involvement in peroxidation and inflammation. On the other hand, peroxidation and inflammation are liable to alter the metabolism of these nutrients, which should be taken into account when assessing their status. Milk products are capable of preventing iron-induced peroxidation and the metabolic complications of the diseases. Calcium, especially cow milk calcium, seems to be capable of preventing the development of adipocytes and obesity complications (inflammation, hypertension, and insulin resistance), mainly through interactions with vitamin D metabolism. These observations give an opportunity to influence the course of obesity by dietetic advices.calcium / trace element / iron / obesity / diabetes / peroxidationRésumé -Rôle des oligo-éléments et du calcium dans les formes de diabète et l'obésité et leurs complications. Effet protecteur des produits laitiers. Les oligo-éléments et les minéraux jouent un rôle dans la genèse de l'obésité, du diabète et de leurs complications métaboliques, en particulier par leur implications dans les phénomènes inflammatoires et la peroxydation. Ces derniers pouvant modifier par eux-mêmes le métabolisme des minéraux, il faut en tenir compte dans l'appréciation de leur statut. Les produits laitiers préviennent la peroxydation liée au fer (rôle principalement joué par les protéines) et les complications métaboliques : ainsi, le calcium, surtout d'origine laitière, interagit avec la vitamine D pour prévenir la différenciation des adipocytes, la lipogenèse et favoriser la production de chaleur ; il lutte contre l'inflammation, l'hypertension et la résistance à l'insuline, composants majeurs du risque cardio-vasculaire. Ces données ouvrent la voie à une intervention non médicamenteuse, sur le long terme, des maladies de civilisation.calcium / oligo-éléments / fer / obésité / diabète / peroxydation *Corresponding author (通讯作者): dbougle@wanadoo.fr Dairy Sci. Technol. 89 (2009) 213-218

show abstract

Increased oxidative stress and hypozincemia in male obesity

Cited by 278 publications

References 22 publications

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Increased glutathione conjugate transport: a possible compensatory protection mechanism against oxidative stress in obesity?

Effects of trace elements and calcium on diabetes and obesity, and their complications: Protective effect of dairy products – A mini-review

Contact Info

Product

Resources

About