Increased oxidative stress and DNA damage in bipolar disorder: A twin-case report

Frey, Benício N.; Andreazza, Ana Cristina; Kunz, Maurício; Gomes, Fabiano A.; Quevedo, Joao L De; Salvador, Mirian; Gonçalves, Carlos Alberto; Kapczinski, Flávio

doi:10.1016/j.pnpbp.2006.06.011

Cited by 108 publications

(72 citation statements)

References 11 publications

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“…Increased SOD activity was associated with manic and depressive episodes but not euthymia, and CAT reduction with mania and euthymia but not depression ). An oxidative profile consistent with these findings were reported in a twin case report of mania (Frey et al, 2007). However, another study reported lowered SOD levels in bipolar depression, in conjunction with elevated NO levels .…”

Section: Human Assays Of Oxidants Antioxidants and Oxidative Productssupporting

confidence: 85%

“…A related theoretical framework for the pathophysiology of bipolar disorder has centred on impaired mitochondrial metabolism as the primary defect in Monozygotic twin case study (Frey et al, 2007) Rise in blood GSH 2-4 h after ECT 20 (mixed diagnoses) (Henneman and Altschule, 1951) bipolar disorder (Kato, 2006;Young, 2007). This concept is supported by data from a number of sources, including magnetic resonance spectroscopy evidence of decreased brain energy metabolism, maternal hereditary patterns, comorbid mitochondrial diseases, mitochondrial mechanisms of mood stabilisers, and mitochondrial DNA deletions, mutations and polymorphisms (Kato, 2007).…”

Section: Molecular and Genetic Studiesmentioning

confidence: 99%

“…Indirect support for the pathophysiological role of oxidative stress in bipolar disorder comes from clinical studies that demonstrate normalisation of oxidative parameters over the course of treatment (Frey et al, 2007;Gergerlioglu et al, 2007;Henneman and Altschule, 1951;Ozcan et al, 2004). This has been elegantly illustrated by a case report of twins presenting with mania, where increased TBARS, SOD and DNA damage, and decreased CAT were observed in both patients prior to treatment.…”

Section: Clinical Studiesmentioning

confidence: 99%

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Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

836

554

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Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.

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Section: Human Assays Of Oxidants Antioxidants and Oxidative Productssupporting

confidence: 85%

Section: Molecular and Genetic Studiesmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

836

554

View full text Add to dashboard Cite

show abstract

“…Os modelos animais de mania efetivamente mostram desbalanço na biologia oxidativa [66][67][68][69][70][71] . Estudos clínicos indicam alto dano oxidativo sistêmico em pacientes com transtorno bipolar [72][73][74][75][76] . Além disso, os sistemas antioxidantes também parecem estar frequentemente alterados, com aumentos significativos nos sistemas da glutationa e da superóxido dismutase 74,75,77 , provavelmente decorrentes de mecanismos compensatórios ao estado pró-oxidativo existente.…”

Section: Estresse Oxidativounclassified

Marcadores periféricos e a fisiopatologia do transtorno bipolar

Magalhães¹,

Fries²,

Kapczinski³

2012

Rev. psiquiatr. clín.

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Introdução: O entendimento da fisiopatologia do transtorno bipolar vem tendo avanços consistentes nos últimos anos. Um enfoque na relação entre carga alostática e alterações sistêmicas vem tomando corpo, com o objetivo de se entender a frequente progressão da doença. Proeminentes entre os mediadores periféricos têm sido as moléculas que poderiam ser amplamente agrupadas em neurotrofinas, marcadores de estresse oxidativo e marcadores inflamatórios. Objetivo: Descrever achados recentes em relação à fisiopatologia sistêmica do transtorno bipolar, com enfoque especial em estudos brasileiros, tentando articular uma visão coerente do conhecimento atual do campo. Método: Revisão narrativa da literatura relacionada a neurotrofinas, estresse oxidativo e marcadores inflamatórios no transtorno bipolar. Resultados: Diversas fontes de evidência, provenientes tanto de estudos pré-clínicos quanto clínicos, revelam consistentemente alterações sistêmicas no transtorno bipolar. Os achados são especialmente robustos em pacientes com múltiplos episódios. Nesses, alterações relacionadas a episódios de mania e depressão são notáveis em neurotrofinas e dano oxidativo a lipídeos. Um número menor de estudos mostra alterações no sistema imune, em particular estados pró-inflamatórios. Conclusão: Alterações sistêmicas que correlacionam o transtorno bipolar a comorbidade clínica, disfunção cognitiva, incapacidade e mortalidade precoce começam a ser traçadas. Estudos envolvendo desenhos longitudinais, amostras populacionais e ensaios clínicos envolvendo marcadores periféricos devem ser incorporados no futuro próximo e reforçar a validade de uma noção de envolvimento multissistêmico no transtorno bipolar.Magalhães PVS, et al. / Rev Psiq Clín. 2012;39(2):60-7 Palavras-chave: Transtorno bipolar, inflamação, estresse oxidativo, neurotrofinas, fator neurotrófico derivado do cérebro, fisiopatologia, biomarcadores. ABSTRACT Introduction:The understanding of the pathophysiology of bipolar disorder has steadily advanced in the past few years. Thereby, a focus on allostatic load and systemic changes has appeared, with the aim to understand illness progression. Amongst the peripheral markers, molecules that can be widely classified into neurotrophins, oxidadive stress markers, and inflammation markers have been elevated. Objective: To describe recent findings regarding the systemic pathophysiology of bipolar disorder, with a special focus on Brazilian studies and to create a coherent view of the current knowledge in the field. Method: Narrative review of the literature regarding neurotrophins, oxidative stress, and inflammatory markers in bipolar disorder. Results: A diverse body of evidence, based on both pre-clinical and clinical studies, reveals consistent systemic changes in bipolar disorder. The findings are particularly robust in patients after multiple episodes. Thereby, remarkable changes related to manic and depressive episodes were found in neurotrophins and oxidative damage to lipids. Regarding to immune system alterations, in particular pro...

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“…[20] A meta-analysis found a significant elevation of oxidative stress biomarkers, such as thiobarbituric acid reactive substances (TBARS) and nitric oxide, during all phases of bipolar illness and preliminary data indicated that oxidative stress may be corrected with pharmacological treatments. [5,6] As mood disorders have a relatively young median age of onset, [21] in the last 30 years pediatric mood disorders have been studied more systematically, especially depression and BD. [22][23][24] In addition, studying clinical features of mood disorders at onset in the offspring of adults with depression or BD has become a promising research approach.…”

Section: Introductionmentioning

confidence: 99%