Increased microRNA-323-3p in IL-22/IL-17-producing T cells and asthma: a role in the regulation of the TGF-β pathway and IL-22 production

Kärner, Jaanika; Wawrzyniak, Marcin; Tankov, Stoyan; Runnel, Toomas; Aints, Alar; Kisand, Kai; Altraja, Alan; Kingo, Külli; Akdiş, Cezmi A.; Rebane, Ana

doi:10.1111/all.12907

Cited by 51 publications

(38 citation statements)

References 51 publications

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“…Decreased expression of miR-26a was previously detected in IL-22-producing T cells, which play an important role in allergic diseases. 25 Variations of miR-26a and its targeted gene HAS3 might play a significant role in the abnormality of the skin barrier in patients with AD.…”

Section: Discussionmentioning

confidence: 99%

Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis

Xiao

Zhong-sheng

et al. 2018

Clin Exp Dermatol

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Section: Discussionmentioning

confidence: 99%

Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis

Xiao

Zhong-sheng

et al. 2018

Clin Exp Dermatol

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“…Some miRNAs have been recognized as important regulators of allergic inflammation . MiR‐323‐3p can control the production of IL‐22 in IL‐22/IL‐17‐producing T cells via a negative feedback loop and impact the T‐cell responses in asthma . In addition, miRNA‐155 is essential to dendritic cells for the initiation and maintenance of allergic airway inflammation.…”

Section: Risk Factorsmentioning

confidence: 99%

“…26 MiR-323-3p can control the production of IL-22 in IL-22/IL-17-producing T cells via a negative feedback loop and impact the T-cell responses in asthma. 27 In addition, miRNA-155 is essential to dendritic cells for the initiation and maintenance of allergic airway inflammation. The deficiency of miRNA-155 can alleviate allergic airway inflammation by reducing Th2 immune reaction and ATP-/P2R-induced activation of dendritic cells in mice, which suggests that miRNA-155 is a potential therapeutic target for allergic airway disease.…”

mentioning

confidence: 99%

Recent developments and highlights in allergic rhinitis

Meng

Wang

Zhang

2019

Allergy

125

105

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Allergic rhinitis (AR) is a disease with high prevalence all over the world and therefore needs to be thoroughly investigated and treated accordingly. The mechanisms underlying the pathology and treatment of AR have been widely studied, but many aspects remain unclear and warrant further investigations. This review presents an overview of recently published papers highlighting the risk factors, mechanisms, and treatment of AR. Additionally, recent studies discussing the role of single nucleotide polymorphism, DNA methylation, regulatory B cells, group 2 innate lymphoid cells, immunotherapy, and biologics in AR are also covered. K E Y W O R D Sallergic rhinitis, biologics, epigenetics, risk factors, treatment | 2321 MENG Et al.

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“…For example, the expression of miR-323-3p in IL-22/IL-17-producing T cells increased in patients with asthma and atopic dermatitis. Study has demonstrated that miR-323-3p may suppress STAT3 mRNA, whereas TGF-β may promote Th22 cells (Kärner et al, 2016). Upon accumulation of IL-22 and IL-17, miR-323-3p produced by T cells inhibits the expression of SMAD2, SMAD3, and STAT3, resulting in diminished production of IL-22.…”

Section: Roles Of Mirnas In Tgf-β-dependent T Cells' Differentiation mentioning

confidence: 99%

TGF-β: Its role in the differentiation and function of T regulatory and effector cells

Yang

Zheng²

2017

Turk J Biol

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The cytokine transforming growth factor-β (TGF-β) plays an important role in the maintenance of T cell homeostasis, immune tolerance to self-antigens, and T cell differentiation during immune responses. TGF-β has pleiotropic effects on adaptive immune responses, especially on the differentiation of T helper and T regulatory cell populations, which depends on the T cell differentiation status and the stimulation conditions. This review provides an update about the roles of TGF-β in T cell responses, especially in the regulation of Treg development and biological features under steady state and inflammation. We also discuss the additional roles that TGF-β plays in the development and function of other T helper cells, such as Th1, Th2, Th9, Th17, and Th22 cells during inflammation.

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Increased microRNA-323-3p in IL-22/IL-17-producing T cells and asthma: a role in the regulation of the TGF-β pathway and IL-22 production

Abstract: Our data suggest that miR-323-3p acts in a negative feedback loop to control the production of IL-22 in IL-22/IL-17-producing T cells and might thus impact the T-cell responses in asthma.

Cited by 51 publications

References 51 publications

Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis

Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis

Recent developments and highlights in allergic rhinitis

TGF-β: Its role in the differentiation and function of T regulatory and effector cells

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