Increased lipid peroxidation and impaired enzymatic antioxidant defense mechanism in thyroid tissue with multinodular goiter and papillary carcinoma

Erdamar, Husamettin; Çimen, Behzat; Gülcemal, Harun; Saraymen, Recep; Yerer, Betül; Demirci, Hüseyin

doi:10.1016/j.clinbiochem.2010.02.005

Cited by 36 publications

(31 citation statements)

References 28 publications

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“…Studies investigating antioxidant status in thyroid diseases may not include all the crucial parameters to ascertain the relationship between thyroid diseases and antioxidants. Most of the previous studies regarding antioxidant status in thyroid diseases were performed either by evaluating antioxidants as a whole (Sivakanesan, Wickramarathne & Nanayakkara, 2014; Wang et al, 2011), or by measuring each antioxidants separately (Cetin et al, 2015; Erdamar et al, 2010; Senthil & Manoharan, 2004). In order to overcome this limitation, in this study, we performed analyses to determine both the antioxidant levels as well as parameters of oxidative stress in patients with thyroid disorders to provide an overall picture with regards to the status of antioxidants and oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

“…However, under normal redox balance, the ROS are removed by antioxidant systems in the body, hence limiting oxidative damage. On the other hand, certain conditions such as inflammation of the thyroid gland as well as tumour cell proliferation could alter the balance between ROS and antioxidant levels (Cetin et al, 2015) in favour of the former, subsequently leading to oxidative damage (Erdamar et al, 2010). In particular, the utilisation of H 2 O 2 for thyroid hormones synthesis causes the thyroid to be easily exposed to oxidative stress in situation where there is disorder in thyroid hormones production (Karbownik-Lewińska & Kokoszko-Bilska, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Although some information is known about the antioxidant status of patients with thyroid disorders (Erdamar et al, 2010; Senthil & Manoharan, 2004; Wang et al, 2011), comparisons between the benign and malignant groups have rarely been performed, especially on two types of benign thyroid disorders which are multinodular goitre (MNG) and follicular thyroid adenoma (FTA). Hence, this study focuses on MNG and FTA as the benign groups, while two of the most common thyroid cancers, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) as the malignant groups.…”

Section: Introductionmentioning

confidence: 99%

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Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders

Ramli

Junit

Leong

et al. 2017

PeerJ

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BackgroundSynthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this study was to measure the antioxidant activities and biomarkers of oxidative stress in serum and red blood cells (RBC) of patients with benign and malignant thyroid disorders and to investigate if changes in the antioxidant activities in these patients were linked to alterations in genes encoding the antioxidant enzymes.MethodsForty-one patients with thyroid disorders from University of Malaya Medical Centre were recruited. They were categorised into four groups: multinodular goitre (MNG) (n = 18), follicular thyroid adenoma (FTA) (n = 7), papillary thyroid cancer (PTC) (n = 10), and follicular thyroid cancer (FTC) (n = 6). Serum and RBC of patients were analysed for antioxidant activities, antioxidant enzymes, and biomarkers of oxidative stress. Alterations in genes encoding the antioxidant enzymes were analysed using whole exome sequencing and PCR–DNA sequencing.ResultsPatients with thyroid disorders had significantly higher serum superoxide dismutase (SOD) and catalase (CAT) activities compared to control, but had lower activities in RBC. There were no significant changes in serum glutathione peroxidase (GPx) activity. Meanwhile, GPx activity in RBC was reduced in PTC and FTC, compared to control and the respective benign groups. Antioxidant activities in serum were decreased in the thyroid disorder groups when compared to the control group. The levels of malondialdehyde (MDA) were elevated in the serum of FTA group when compared to controls, while in the RBC, only the MNG and PTC groups showed higher MDA equivalents than control. Serum reactive oxygen species (ROS) levels in PTC group of both serum and RBC were significantly higher than control group. Whole exome sequencing has resulted in identification of 49 single nucleotide polymorphisms (SNPs) in MNG and PTC patients and their genotypic and allelic frequencies were calculated. Analyses of the relationship between serum enzyme activities and the total SNPs identified in both groups revealed no correlation.DiscussionDifferent forms of thyroid disorders influence the levels of antioxidant status in the serum and RBC of these patients, implying varying capability of preventing oxidative stress. A more comprehensive study with a larger target population should be done in order to further evaluate the relationships between antioxidant enzymes gene polymorphisms and thyroid disorders, as well as strengthening the minor evidences provided in literatures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders

Ramli

Junit

Leong

et al. 2017

PeerJ

View full text Add to dashboard Cite

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“…In fact, BG tissue produced more oxidants than normal and tumor tissue of PTC patients. Erdamar et al (2010) observed increased pro-oxidant activity such as lipid peroxidation and impaired antioxidant defense mechanisms in both tissue of patients with non-toxic and toxic multinodular goiter and those with PTC. In contrast, TAS values were significantly higher in PTC tumor tissue than in nearby normal tissue and BG tissue.…”

Section: Discussionmentioning

confidence: 94%

Papillary Thyroid Carcinoma: A Malignant Tumor with Increased Antioxidant Defense Capacity

Rovčanin

Gopčević

Kekić

et al. 2016

Tohoku J. Exp. Med.

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Papillary thyroid carcinoma (PTC) is the commonest thyroid malignancy worldwide for which the radiation exposure is the most influential risk factor. The levels of oxidative stress in PTC are not well characterized on the tissue level. The objective of this study was to evaluate total oxidant status (TOS) and total antioxidant status (TAS) in PTC and benign goiter (BG) tissues and to examine their association with clinicopathological characteristics. Tumor and normal thyroid tissue samples were collected from 59 PTC patients, and goiter tissues were collected from 50 BG patients. TOS and TAS were quantified in the tissue homogenates by spectrophotometric assays. TOS values in tumor tissues did not differ significantly from normal and goiter tissues; however, PTC tissues have significantly higher TAS values than normal and goiter tissues. TOS values correlated with retrosternal growth in BG patients. The significant correlations were found between TOS and TAS values and thyroid function parameters. In 17 PTC patients with multiple tumor foci (multicentric phenotype), TAS values were significantly lower, compared to 42 patients with unicentric PTC. TAS and TOS are the most useful predictors of thyroid capsular invasion by PTC. The age, sex, body mass index, smoking, familial history of thyroid disease and nodule size did not influence TOS and TAS in PTC or BG patients. In conclusion, we show the profiles of TOS and TAS in PTC and BG tissues. Importantly, PTC tissues possess increased antioxidant capacity. The redox status influences the parameters of the thyroid function and tumor's biological behavior.

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“…Evidently, free radicals are involved in the physiological and pathological processes in the thyroid gland (13,14). According to previous studies, thyroid cancer is associated with enhanced oxidative stress (15,16).…”

Section: Discussionmentioning

confidence: 99%

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

et al. 2018

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Background: Oxidative stress has been shown to be the most significant influential factor in cancer pathogenesis. Follicular cells are affected in papillary thyroid carcinoma (PTC), which is the most prevalent thyroid cancer associated with oxidative stress. As a noninvasive source of body metabolism, saliva has recently attracted the attention of researchers as an investigative specimen. The present study aimed to evaluate and compare the levels of total antioxidant capacity (TAC) and malondialdehyde (MDA) in the blood and saliva samples of PTC patients and healthy control subjects. Methods: This case-control study was conducted on the patients with PTC referring to Taleghani Hospital in Tehran, Iran. Age-and gender-matched healthy volunteers were selected as the control group. Blood and saliva samples were obtained from all the subjects. Measurement of the MDA and TAC levels was performed using a commercial kit (ZellBio GmbH, Germany) based on colorimetric methods. Data analysis was performed in MedCalc software version 14.8.1.

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Increased lipid peroxidation and impaired enzymatic antioxidant defense mechanism in thyroid tissue with multinodular goiter and papillary carcinoma

Cited by 36 publications

References 28 publications

Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders

Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders

Papillary Thyroid Carcinoma: A Malignant Tumor with Increased Antioxidant Defense Capacity

Salivary Lipid Peroxidation and Antioxidant Status in the Patients with Papillary Thyroid Carcinoma: A Case-Control Study

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