Increased insulin resistance in men with unexplained infertility

Abstract

This prospective case-control study aimed to test the presence of insulin resistance (IR) in men with unexplained infertility. We included two groups: the study group including 160 infertile men with unexplained oligozoospermia (sperm count <10 × 10/ml) and normal hormonal profile, and the control group of 79 men with proven fertility within the preceding year. A fasting blood test measured IR, FSH, LH, total cholesterol, low-density lipoprotein, high-density lipoprotein and triglycerides. Insulin level was significantly higher in the study group (13.67 ± 10.44) compared with the control group (5.46 ± 3.15), P < 0.0001, and IR was significantly higher in the study group, P < 0.0001. FSH was significantly (P < 0.0001) higher in the study group (4.71 ± 2.57) than the control group (3.15 ± 1.92). LH was significantly higher in the study group (4.98 ± 2.41) compared with the control group (3.15 ± 1.12), P < 0.0001. Total cholesterol was significantly higher in the study group (198.29 ± 37.52) than the control group (182.45 ± 35.92), P < 0.05. In conclusion, IR in men with unexplained infertility may be a cause of reproductive and metabolic abnormalities. The benefit of insulin-sensitizing agents for these patients should be tested.

Insulin resistance and idiopathic infertility: A potential possible link

“…Our findings agreed also with Mansour et al. (2017); who stated that insulin resistance was found to be higher in patients with unexplained infertility in comparison with controls.…”

Anethum graveolens L‎. Alleviates Sperm ‎Damage by Limiting Oxidative Stress ‎and Insulin ‎Resistance ‎in ‎Diabetic Rats ‎

“…It has been reported that diabetes is accompanied by augmented levels of apoptosis of germ cells in testes and disturbance of spermatogenesis [27,28], which are associated with hormonal alterations, oxidative stress and hyperglycemia [29]. Diabetic subjects have reduced anti-oxidant capacity and/or raised oxidative damage in different tissues.…”

“…In this study, Dill also ameliorated HOMA-IR in T2D rats. Notably, insulin resistance is of extreme importance in spermatogenesis since insulin controls the metabolic co-operation between testis and its need for normal testicular action [29].…”

Exploration of Ayurveda blueprint on clinical physiology of Meda (adipose tissue) and Majja Dhatu (bone marrow) in context to obesity

“…Vitiated Medo Dhatavagni will also lead to the productions of Aama, which circulates in the whole body, affecting the metabolism as well as nourishment of other Dhatu. These factors produce a circumstance of over nourishment of Meda Dhatu and undernourishment of other Dhatu (Shrikanth et al, 2009;Dwivedi et al, 2016e) The whole mechanism can be understood from the different manifestation of obesity as described in Figure 1 ( Nagpal et al, 2018;Oussaada et al, 2019;Simonds et al, 2012;Romeo et al, 2012;Akhmedov and Berdeaux, 2013;Patel et al, 2018;Cao, 2011;Jungheim et al, 2012;Mansour et al, 2017;Crujeiras and Casanueva, 2015).…”