Increased inflammatory biomarkers in early pregnancy is associated with the development of pre‐eclampsia in patients with periodontitis: a case control study

Chaparro, Alejandra; Sanz, A; Quintero, A; Inostroza, Carolina; Ramı́rez, Valeria; Carrión, F; Figueroa, Fernando; Serra, Ramón; Illanes, Sebastián E.

doi:10.1111/jre.12008

Cited by 38 publications

(33 citation statements)

References 45 publications

(71 reference statements)

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“…Thirty‐two studies in total reported on C‐reactive protein levels,21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52 of which 17 were applicable for meta‐analysis 21, 22, 23, 29, 30, 31, 32, 33, 34, 37, 38, 39, 41, 42, 47, 49, 50. A significantly higher C‐reactive protein was found in women with pre‐eclampsia than in non‐hypertensive controls ( Figure 2), and this correlation was stronger in severe than in mild pre‐eclampsia ( Figure 3).…”

Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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Evidence accumulates for associations between hypertensive pregnancy disorders and increased cardiovascular risk later. The main goal of this study was to explore shared biomarkers representing common pathogenic pathways between heart failure with preserved ejection fraction (HFpEF) and pre‐eclampsia where these biomarkers might be potentially eligible for cardiovascular risk stratification in women after hypertensive pregnancy disorders. We sought for blood markers in women with diastolic dysfunction in a first literature search, and through a second search, we investigated whether these same biochemical markers were present in pre‐eclampsia.This systematic review and meta‐analysis presents two subsequent systematic searches in PubMed and EMBASE. Search I yielded 3014 studies on biomarkers discriminating women with HFpEF from female controls, of which 13 studies on 11 biochemical markers were included. Cases had HFpEF, and controls had no heart failure. The second search was for studies discriminating women with pre‐eclampsia from women with non‐hypertensive pregnancies with at least one of the biomarkers found in Search I. Search II yielded 1869 studies, of which 51 studies on seven biomarkers were included in meta‐analyses and 79 studies on 12 biomarkers in systematic review.Eleven biological markers differentiated women with diastolic dysfunction from controls, of which the following 10 markers differentiated women with pre‐eclampsia from controls as well: C‐reactive protein, HDL, insulin, fatty acid‐binding protein 4, brain natriuretic peptide, N terminal pro brain natriuretic peptide, adrenomedullin, mid‐region pro adrenomedullin, cardiac troponin I, and cancer antigen 125.Our study supports the hypothesis that HFpEF in women shares a common pathogenic background with pre‐eclampsia. The biomarkers representing inflammatory state, disturbances in myocardial function/structure, and unfavourable lipid metabolism may possibly be eligible for future prognostic tools.

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Section: Resultsmentioning

confidence: 99%

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

et al. 2017

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“…Indeed, our research group recently reported that pregnant women with periodontitis who later developed pre‐eclampsia showed increased levels of IL‐6 in gingival crevicular fluid and C‐reactive protein in plasma during early pregnancy .…”

Section: Discussionmentioning

confidence: 99%

“…It has been hypothesized that exacerbation of this inflammatory response during pregnancy by other pathologies might also be a predisposing factor for the occurrence of hypertensive disorders . Within this context, we previously demonstrated that the presence of periodontal disease was associated with an increase of IL‐6 in the gingival crevicular fluid in early pregnancy and with the development of pre‐eclampsia .…”

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confidence: 91%

Porphyromonas gingivalis,Treponema denticola and toll‐like receptor 2 are associated with hypertensive disorders in placental tissue: a case–control study

Chaparro

Blanlot

Ramı́rez

et al. 2013

J of Periodontal Research

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In the present study, pregnant women with periodontal disease presented an association in the placental tissue between the presence of T. denticola and P. gingivalis and hypertensive disorders. Additionally, increased expression of TLR-2 was observed. However, further studies are required to determine the specific roles of periodontal pathogens and TLRs in the placental tissue of patients with pregnancy-related hypertensive disorders.

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“…Porphyromonas gingivalis (Pg) is an important Gram-negative periodontal pathogen of humans that is also implicated in promoting cardiovascular disease [19], low birth weight, IUGR, preeclampsia, and spontaneous preterm birth [15][16][17][20][21][22][23][24][25][26]. In women with complicated pregnancies, the rate of detection of Pg DNA or antigen within the uterine compartment ranges between 30 and 92% [15-17, 22, 25].…”

Section: Introductionmentioning

confidence: 99%

Porphyromonas gingivalis strain-dependent inhibition of uterine spiral artery remodeling in the pregnant rat†

Phillips

Brown

Progulske‐Fox

et al. 2018

Biology of Reproduction

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Porphyromonas gingivalis (Pg) is an important periodontal pathogen that is also implicated in pregnancy complications involving defective deep placentation (DDP). We hypothesized that Pg invasion of the placental bed promotes DDP. Pregnant rats were intravenously inoculated with sterile vehicle, Pg strain W83, or A7436 at gestation day (GD) 14 (acute cohort). Nonpregnant rats received repeated oral inoculations for 3 months before breeding (chronic cohort). Tissues and/or sera were collected at GD18 for analysis. Pg infection status was determined by seroconversion (chronic cohort) and by presence of Pg antigen in utero-placental tissues processed for histology and morphometric assessment of spiral artery remodeling. Mesometrial tissues from seropositive dams were analyzed for expression of interleukin 1β, 6, and 10, TNF, TGF-β, follistatin-related protein 3, and inhibin beta A chain since these genes regulate extravillous trophoblast invasion. The in situ distribution of W83 and A7436 antigen in utero-placental tissues was similar in both cohorts. In the acute cohort, mesometrial stromal necrosis was more common with W83, but arteritis was more common with A7436 infection (P < 0.05). Increased vascular necrosis was seen in mesometrium of chronically infected groups (P < 0.05). Only A7436-infected animals had increased fetal deaths, reduced spiral artery remodeling, reduced inhibin beta A expression, and an increased proportion of FSLT3 positive extravillous trophoblasts within spiral arteries. While infection with both Pg strains produced varying pathology of the deep placental bed, only infection with strain A7436 resulted in impaired spiral artery remodeling.Published by Oxford University Press on behalf of Society for the Study of Reproduction 2018. This work is written by (a) US Government employee(s) and is in the public domain in the US. 1045Downloaded from https://academic.oup.com/biolreprod/article-abstract/99/5/1045/4999895 by guest on 07 June 2019 1046 P. Phillips et al., 2018, Vol. 99, No. 5 Summary SentenceInvasion of the placental bed by Porphyromonas gingivalis impairs spiral artery remodeling and increases fetal loss in a microbial strain-dependent manner.

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Increased inflammatory biomarkers in early pregnancy is associated with the development of pre‐eclampsia in patients with periodontitis: a case control study

Cited by 38 publications

References 45 publications

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

Porphyromonas gingivalis,Treponema denticola and toll‐like receptor 2 are associated with hypertensive disorders in placental tissue: a case–control study

Porphyromonas gingivalis strain-dependent inhibition of uterine spiral artery remodeling in the pregnant rat†

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