Increased incidence of urinary tract infection in patients with rheumatoid arthritis and secondary Sjogren's syndrome.

Tishler, Moshe; Caspi, Dan; Almog, Yehoshua; Segal, R; Yaron, Michael

doi:10.1136/ard.51.5.604

Cited by 30 publications

(21 citation statements)

References 10 publications

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“…None the less, there exists research devoted to patients with rheumatoid arthritis (RA) which concludes that whenever RA and Sjögren's syndrome are associated, the incidence of UTI is more frequent in those patients. 40 In our research, we could not find this specific association, which may be because only a small number of lupus patients also had Sjögren's syndrome at the same time.…”

Section: Discussioncontrasting

confidence: 64%

Urinary tract infections and lupus erythematosus

Hidalgo-Tenorio

Jiménez-Alonso²,

Luna³

et al. 2004

Annals of the Rheumatic Diseases

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Background: Infections are one of the main causes of morbidity and mortality in patients with systemic lupus erythematosus. Objective: To analyse urinary tract infection (UTI) risk factors in lupus patients; the influence of these factors on disease activity, organ damage, and disease development; the type and prevalence of UTI; and the micro-organisms involved. Method: 86 control subjects and 81 lupus patients were studied prospectively over a 12 month period and examined on five occasions. Epidemiological data and information on urinary symptoms, disease activity (SLEDAI), and organ damage (SLICC/ACR) data were collected. Autoantibodies, complement levels, urine culture, and antibiogram were determined; urological studies were also carried out. SPPS 10.0 and STATA 6.0. were used for statistical analysis. Results: The prevalence of UTI in lupus patients was 36%. Lupus influences the onset of UTI (p = 0.001), regardless of other variables. UTI risk factors in lupus patients were age (p = 0.002), previous cases of UTI (p = 0.0001), antinuclear antibodies (ANA) .1/80 IU/ml (p = 0.022), thrombocytopenia (p = 0.02), and admission to hospital due to UTI (p = 0.002). Leucopenia (p = 0.09) and the weekly administration of methotrexate (p = 0.06) had a bearing on the onset of UTI; disease development (p = 0.99), lupus activity (p = 0.32), and organ damage (p = 0.36) do not. The uropathogen most frequently isolated was E coli (60%). Conclusions: Lupus patients are likely to have UTI, usually manifesting in the lower tract. They are community acquired, basically caused by E coli, and favoured by age, previous UTI, admissions to hospital due to UTI, thrombopenia, ANA, leucopenia, and methotrexate treatments.

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Section: Discussioncontrasting

confidence: 64%

Urinary tract infections and lupus erythematosus

Hidalgo-Tenorio

Jiménez-Alonso²,

Luna³

et al. 2004

Annals of the Rheumatic Diseases

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“…26 Second, female patients with sicca syndrome might suffer from local irritation of the urinary bladder due to vaginal sicca. 6,27 Finally, Tishler et al 10 reported that patients with RA and secondary SS had a higher prevalence of urinary tract infections, which could also be a contributing factor to overactive bladder.…”

Section: Discussionmentioning

confidence: 98%

“…Furthermore, the increased incidence of urinary tract infection in patients with secondary SS might also play a role. 10 In the present study, we reviewed the clinical data, including LUTS, bladder diary entries, urodynamic studies, cystoscopy, and treatment outcomes from a cohort of patients with SS. Through the data analysis, we attempted to clarify the characteristics and explore the potential etiologies of LUTS in these patients.…”

Section: Introductionmentioning

confidence: 99%

Multifactorial causes of irritating bladder symptoms in patients with sjögren's syndrome

Lee

Dong

Chen

et al. 2010

Neurourology and Urodynamics

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“…It has been reported that patients with RA suffer an increase in UTI [9]. The presence of specific antibodies to P. mirabilis in RA patients It0] and the isolation of P. mirabilis from the urine of such patients leads to the suggestion that this organism is one possible candidate for the role of a trigger factor involved in RA.…”

Section: Fig 2 Correlation Of Anti-proteus Antibodies With Proteus Cmentioning

confidence: 99%

Correlation between anti-Proteus antibodies and isolation rates ofP. mirabilis in rheumatoid arthritis

et al. 1997

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In a survey of 89 RA patients, carried out under code, Proteus mirabilis was isolated from the urine of 63% (47/75) of female (P<0.001) and 50% (7/14) of male patients (P < 0.001), compared to a frequency of isolation in healthy women of 32% (38/119) and 11% (13/115) in healthy men. There was no significant difference in isolation rates between 37 non-RA patients and healthy controls. Sera from 20 patients with RA and 20 healthy controls were tested against P. mirabilis and Escherichia coli by an enzyme-linked immunosorbent assay. Antibodies against P. mirabilis but not to E. coli were significantly higher in the RA patients than in healthy controls (P < 0.001). Furthermore, a positive correlation was found between high anti-Proteus antibody levels in serum samples and the number of Proteus colony-forming units obtained from urine specimens of the 20 RA patients (r = +0.714, P < 0.001). These results support the suggestion of an aetiopathogenic role for P. mirabilis in RA.

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Increased incidence of urinary tract infection in patients with rheumatoid arthritis and secondary Sjogren's syndrome.

Cited by 30 publications

References 10 publications

Urinary tract infections and lupus erythematosus

Urinary tract infections and lupus erythematosus

Multifactorial causes of irritating bladder symptoms in patients with sjögren's syndrome

Correlation between anti-Proteus antibodies and isolation rates ofP. mirabilis in rheumatoid arthritis

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