Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis

Toussirot, Eric; Laheurte, Caroline; Gaugler, Béatrice; Gabriel, Damien; Saas, Philippe

doi:10.3389/fimmu.2018.01610

Cited by 53 publications

(55 citation statements)

References 32 publications

(60 reference statements)

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“…In addition, IL-17 and granulocyte monocyte colony stimulating factor (GM-CSF) double producing γδ T cells were found to be increased in PB of AS patients when compared to RA patients and normal PB, similar to what was found with respect to CD4, CD8 and natural-killer (NK) cells [82]. Another study confirmed that double expressing IL-17 and GMCSF γδ as well as CD4, CD8, and ILC cells are found in synovium and increased in PB of AS patients, whereas there was a decreased percent of γδ T cells in their PB relative to normal [83]. Interestingly, in contrast to IL23R + IL-17 + Vδ1 + T cells that are expanded in AS, Vδ2 + γδ T cells were found to be increased in patients with AS who were receiving infliximab (anti TNFα) therapy, relative to those not receiving this drug and HC.…”

Section: Ankylosing Spondylitis (As)supporting

confidence: 70%

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Bank

2020

Cells

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Autoimmune rheumatic diseases (ARDs), affecting ~1–1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs, kindling interest in their role in the immuno-pathogenesis of these chronic inflammatory conditions. Indeed, later studies applied rapid developments in the understanding of γδ T cell biology, including antigens recognized by γδ T cells, their developmental programs, states of activation, and cytokine production profiles, to analyze their contribution to the pathological immune response in these disorders. Here we review the published studies addressing the role of γδ T in the major autoimmune rheumatic diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, systemic lupus erythematosus and scleroderma, and animal models thereof. Due to their unique properties spanning adaptive and innate immune functions, the ever deeper understanding of this unique T cell population is shedding new light on the pathogenesis of, while potentially enabling new therapeutic approaches to, these diseases.

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Section: Ankylosing Spondylitis (As)supporting

confidence: 70%

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Bank

2020

Cells

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“…In Mr1 −/− NOD mice, exacerbation of diabetes development is associated with a loss of gut barrier integrity, allowing the translocation of bacterial compounds and subsequent dendritic cell activation in pancreatic lymph nodes 70 . Of note, a protective role of IL-17 has been established in several intestinal inflammation models 116 , and IL-22 + MAIT cells have been observed in the blood of patients with UC 18 and AS 84 .…”

Section: Prevention Of T1d By Mait Cellsmentioning

confidence: 99%

“…Accordingly, total splenocytes from Mr1 −/− mice produce lower levels of IL-17 after anti-CD3 and anti-CD28 stimulation or IL-23 treatment. Human studies highlight a switch towards a T H 17-type profile of blood MAIT cells, with an increase in secretion of IL-17 in patients with CD 18 , UC 18,79 , ankylosing spondylitis (AS) 77 , obesity 16,73 , type 2 diabetes (T2D) 16 and cirrhosis 69 , and of IL-22 in patients with UC 18 and AS 84 . Analysis of MAIT cells in patients with MS has further shown increased expression of RORγt, CCR6 and IL-7R compared with healthy controls 118 .…”

Section: Pathogenic Role Of Il-17-producing Mait Cellsmentioning

confidence: 99%

“…Similarly, IL-17 production is increased in MAIT cells from the salivary glands of patients with Sjögren syndrome (SS) compared with controls 78,86 , as well as after stimulation with IL-23 in vitro 78 . In AS, the altered cytokine profile of blood MAIT cells is also observed in the synovial fluid in favour of IL-17 production 77,84 , and IL-7 priming of MAIT cells increases IL-17 production in patients compared with healthy controls 77 . Of note, IL-7 levels are elevated in the joints and gut of AS patients 119,120 , and there is a positive correlation between IL-7 and IL-17 levels in these patients 121 .…”

Section: Pathogenic Role Of Il-17-producing Mait Cellsmentioning

confidence: 99%

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Mucosal-associated invariant T cells and disease

et al. 2019

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Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacterial and viral infections. However, they can also have various deleterious and protective functions in autoimmune, inflammatory and metabolic diseases. MAIT cell involvement in a large spectrum of pathological conditions makes them attractive targets for potential therapeutic approaches.

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“…In addition, MAIT cells were found to be involved in AS. Although the frequency of circulating MAIT cells was lower than in healthy controls, the proportion of IL-17+ MAIT cells in the blood of patients with AS was elevated [ 87 , 88 , 89 ]. Higher proportions of MAIT cells were found in the synovial fluid than in the circulation.…”

Section: Il-17mentioning

confidence: 99%

The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis

Tsukazaki

Kaito

2020

IJMS

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Spondyloarthritis (SpA) is a subset of seronegative rheumatic-related autoimmune diseases that consist of ankylosing spondylitis (AS), psoriatic spondylitis (PsA), reactive spondylitis (re-SpA), inflammatory bowel disease (IBD)-associated spondylitis, and unclassifiable spondylitis. These subsets share clinical phenotypes such as joint inflammation and extra-articular manifestations (uveitis, IBD, and psoriasis [Ps]). Inflammation at the enthesis, where ligaments and tendons attach to bones, characterizes and distinguishes SpA from other types of arthritis. Over the past several years, genetic, experimental, and clinical studies have accumulated evidence showing that the IL-23/IL-17 axis plays a critical role in the pathogenesis of SpA. These discoveries include genetic association and the identification of IL-23- and IL-17-producing cells in the tissue of mouse models and human patients. In this review, we summarize the current knowledge of the pathomechanism by focusing on the IL-23/IL-17 pathway and examine the recent clinical studies of biological agents targeting IL-23 and IL-17 in the treatment of SpA.

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Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis

Cited by 53 publications

References 32 publications

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

Mucosal-associated invariant T cells and disease

The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis

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