“…In fact, cell senescence, especially senescence of dermal fibroblasts, has been postulated as a driver of skin ageing in many recent reviews ( Campisi et al, 2019 , Demaria et al, 2015 , Fitsiou et al, 2021 , Ho and Dreesen, 2021 , Lee, 2021 , Lee et al, 2021a , Lee et al, 2021b , Toutfaire et al, 2017 , Velarde and Demaria, 2016 , Wang and Dreesen, 2018 , Wlaschek et al, 2021 ). There is already good evidence for a causal role of cell senescence in photoaging of the skin, which has been covered in multiple recent reviews ( Cavinato and Jansen-Dürr, 2017 , Fitsiou et al, 2021 , Toutfaire et al, 2017 , Velarde and Demaria, 2016 ).…”