Increased helper-suppressor T-cell ratio in psoriasis

Abstract

Numerous investigations have suggested an immunologic pathogenesis of psoriasis and diminished suppressor T-cell activity of psoriatic blood. Consequently, a study was undertaken to explain whether diminished suppressor cell activity was a result of quantitative alterations of the T-lymphocyte subpopulation. Twenty patients with psoriasis and 20 normal control subjects were randomly selected. Our findings demonstrated a significant decrease in the percentage of suppressor cells (T gamma), a significant elevation of helper cells (T mu), and a highly significant increase in the helper-suppressor T-cell ratio (T mu/T gamma) of psoriatic blood compared with that of normal control subjects. Our study gives further support to the possible role of immunologic factors in the pathogenesis of psoriasis.

Literature Review of the Korean Medicinal Approaches to Immunohistochemical Research on Psoriasis

“…에 대한 감작 반응 감소12) , 억제 T세포 수의 감소와 말초 혈액 보조 T세포 수와 억제 T세포 수 비의 증 가13) , 억제 T세포의 기능 장애14) 등으로 다양하며 국 내에서도 다양한 방법으로 T세포와 그 아형에 대한 연구가 진행되었다. 김 등 15) 이 건선환자에서 총 T세포 및 조기 T세포 (Early rosette forming lymphocyte)의 백분율이 정상 대조군에 비해 감소되어있음과 조기 T세포는 병변범 위가 넓을수록 더욱 감소함을 보고하였다.…”