Increased generation of superoxide radicals in the blood of MS patients

Głąbiński, Andrzej; Tawsek, N. S.; Bartosz, Grzegorz

doi:10.1111/j.1600-0404.1993.tb04212.x

Cited by 42 publications

(11 citation statements)

References 24 publications

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“…Similar results were obtained by Głąbiński et al [20]. They found increased generation of the superoxide radical after PMA stimulation in blood of MS patients.…”

Section: Discussionsupporting

confidence: 89%

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Do catalase and glutathione peroxidase protect blood platelets from lipid peroxidation in multiple sclerosis?

Fijałkowski¹,

Jędrzejczak-Pospiech²,

Błaszczyk³

2018

ppn

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Purpose: Catalase (cat) and glutathione peroxidase (GSH-Px) activities and thiobarbituric acid reactive substances (TBARS) concentration in blood platelets were determined in patients with multiple sclerosis (MS). Methods: The study was carried out in a group of 36 patients, men and women, aged 21-50 years old. They were divided into groups dependently on the degree of motor disability and duration of the disease. The control group included 15 healthy individuals of similar age to the study group. The activity of catalase was estimated according to the method by Beers and Sizer. Glutathione peroxidase activity was determined by the method of Sedlak and Lindsay, modified by Little and O'Brien. The concentration of thiobarbituric acid reactive substances in blood platelets was carried out using the method by Placer et al. Results: We observed a lower level of TBARS concentration in platelets of MS patients than in control group with an enhanced activities of both antioxidative enzymes on the basis of disability degree and duration of the disease. Conclusions: Catalase and glutathione peroxidase protect blood platelets from lipid peroxidation process in multiple sclerosis patients and may play a role in the course of the disease. It may also suggest involvement of lipid peroxidation in the activity of multiple sclerosis.

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“…Similar results were obtained by Głąbiński et al [20]. They found increased generation of the superoxide radical after PMA stimulation in blood of MS patients.…”

Section: Discussionsupporting

confidence: 89%

“…They found that MS patients with acute exacerbation of the disease had significantly higher concentrations of pentane compared to either patients in remission or control subjects. Increased levels of lipid peroxidation products in cerebrospinal fluid and increased erythrocyte peroxidisability were also reported in MS patients [20].…”

Section: Discussionmentioning

confidence: 92%

Do catalase and glutathione peroxidase protect blood platelets from lipid peroxidation in multiple sclerosis?

Fijałkowski¹,

Jędrzejczak-Pospiech²,

Błaszczyk³

2018

ppn

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“…These findings suggest that widespread disruptions in brain biochemistry may contribute to myelin and axonal damage in tissues that appear normal on gross examination. Multiple lines of evidence corroborate findings from brain imaging studies including findings of cytokine imbalance, oxidative stress, cytoskeletal damage and neurotransmitter abnormalities (Glabinski et al , 1993 ; Semra et al , 2002 ; Bartosik-Psujek and Stelmasiak, 2006 ; Skundric et al , 2006 ; Bartos et al , 2007 a , b ).…”

Section: Introductionmentioning

confidence: 53%

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

Wheeler

Bandaru

Calabresi

et al. 2008

Brain

151

129

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Maintaining the appropriate complement and content of lipids in cellular membranes is critical for normal neural function. Accumulating evidence suggests that even subtle perturbations in the lipid content of neurons and myelin can disrupt their function and may contribute to myelin and axonal degradation. In this study, we determined the composition and quantified the content of lipids and sterols in normal appearing white matter (NAWM) and normal appearing grey matter (NAGM) from control and multiple sclerosis brain tissues by electrospray ionization tandem mass spectrometry. Our results suggest that in active-multiple sclerosis, there is a shift in the lipid composition of NAWM and NAGM to a higher phospholipid and lower sphingolipid content. We found that this disturbance in lipid composition was reduced in NAGM but not in NAWM of inactive-multiple sclerosis. The pattern of disturbance in lipid composition suggests a metabolic defect that causes sphingolipids to be shuttled to phospholipid production. Modelling the biophysical consequence of this change in lipid composition of NAWM indicated an increase in the repulsive force between opposing bilayers that could explain decompaction and disruption of myelin structure.

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“…With cytokine activation, free‐radical production increases and this has been demonstrated in MS (Glabiński et al. ). NAC inhibits the toxicity of TNF and in an animal model of MS, it inhibited the development of MS‐like pathology (Lehmann et al.…”

Section: Introductionmentioning

confidence: 91%

“…There is a marked increase in expression of TNF in active multiple sclerosis (MS), and a correlation exists between cerebrospinal fluid levels of TNF and the severity and progression of disease (Sharief and Hentges 1991). With cytokine activation, free-radical production increases and this has been demonstrated in MS (Glabi nski et al 1993). NAC inhibits the toxicity of TNF and in an animal model of MS, it inhibited the development of MS-like pathology (Lehmann et al 1994).…”

Section: Multiple Sclerosismentioning

confidence: 99%

N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

2014

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BackgroundThere is an expanding field of research investigating the benefits of medicines with multiple mechanisms of action across neurological disorders. N-acetylcysteine (NAC), widely known as an antidote to acetaminophen overdose, is now emerging as treatment of vascular and nonvascular neurological disorders. NAC as a precursor to the antioxidant glutathione modulates glutamatergic, neurotrophic, and inflammatory pathways.Aim and discussionMost NAC studies up to date have been carried out in animal models of various neurological disorders with only a few studies completed in humans. In psychiatry, NAC has been tested in over 20 clinical trials as an adjunctive treatment; however, this topic is beyond the scope of this review. Herein, we discuss NAC molecular, intracellular, and systemic effects, focusing on its potential applications in neurodegenerative diseases including spinocerebellar ataxia, Parkinson's disease, tardive dyskinesia, myoclonus epilepsy of the Unverricht–Lundbor type as well as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease.ConclusionFinally, we review the potential applications of NAC to facilitate recovery after traumatic brain injury, cerebral ischemia, and in treatment of cerebrovascular vasospasm after subarachnoid hemorrhage.

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Increased generation of superoxide radicals in the blood of MS patients

Cited by 42 publications

References 24 publications

Do catalase and glutathione peroxidase protect blood platelets from lipid peroxidation in multiple sclerosis?

Do catalase and glutathione peroxidase protect blood platelets from lipid peroxidation in multiple sclerosis?

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

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