Increased frequency of HL-A10 in pemphigus vulgaris

Krain, L. S.

doi:10.1001/archderm.108.6.803

Cited by 23 publications

(9 citation statements)

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“…Association of HLA‐A alleles with PV was shown in some previous studies; a significant association of HLA‐A10 was documented in Jewish patients with PV . Subsequently, the association of this allele was also confirmed in Ashkenazi Jewish patients .…”

Section: Discussionmentioning

confidence: 62%

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

Mortazavi

Amirzargar

Esmaili

et al. 2013

The Journal of Dermatology

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There are a limited number of reports indicating the role of human leukocyte antigen (HLA) class I alleles in pemphigus vulgaris. This study was designed to highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. Fifty patients with pemphigus vulgaris, diagnosed based on clinical, histological and direct immunofluorescence findings were enrolled into this study. The control group consisted of 50 healthy, age- and sex-matched individuals. HLA typing of class I (A, B and C alleles) was carried out using polymerase chain reaction based on the sequence-specific primer method. This study showed the higher frequency of HLA-B*44:02 (P = 0.007), -C*04:01 (P < 0.001), -C*15:02 (P < 0.001) and -C*16:01 (P = 0.027) in the patient group, compared to the controls, while the frequency of HLA-C*06:02 (P < 0.001) and -C*18:01 (P = 0.008) in the patients with pemphigus vulgaris was significantly lower than the controls. Regarding the linkage disequilibrium between HLA class I alleles, the HLA-A*03:01, -B*51:01, -C*16:02 haplotype (4% vs 0%, P = 0.04) is suggested to be a predisposing factor, whereas HLA-A*26:01, -B*38, -C*12:03 haplotype (0% vs 6%, P = 0.01) is suggested to be a protective factor. In conclusion, it is suggested that HLA-B*44:02, -C*04:01, -C*15:02 alleles and HLA-A*03:01, -B*51:01, -C*16:02 haplotype are susceptibility factors for development of pemphigus vulgaris in the Iranian population, while HLA-C*06:02, -C*18:01 alleles and HLA-A*26:01, -B*38, -C*12:03 haplotype may be considered as protective alleles.

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Section: Discussionmentioning

confidence: 62%

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

Mortazavi

Amirzargar

Esmaili

et al. 2013

The Journal of Dermatology

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“…and Park et al . found that the association of HLA‐A10 with pemphigus among Jewish female patients is higher than that among males 9,10 . However, in recent studies the status of HLA class II antigens were more emphasized than class I in pemphigus.…”

Section: Discussionmentioning

confidence: 99%

HLA‐class 1 and class 2 antigens in Turkish patients with pemphigus

et al. 2002

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“…Interactions among genetic and environmental factors are important in the etiopathogenesis of pemphigus 4 . Genetic factors that predispose individuals to pemphigus are considered to play important roles in the development of the disease 5–11 . As in all organ‐specific autoimmune diseases, tolerance breakage to target autoantigens is thought, although not exclusively, to take place at the T cell level (i.e.…”

Section: Introductionmentioning

confidence: 99%

Human leukocyte antigens class I and class II in patients with pemphigus in southern Turkey

Koc¹,

Sallakçı

Akman-Karakaş³

et al. 2012

Int J Dermatology

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The results suggest that DRB1*04, DRB1*14, DQB1*05, and DPB1*0401 class II HLAs and A*11 and CW*01 class I HLAs are associated with pemphigus in southern Turkey. Observed differences in LD patterns between patients and controls suggest that the coexistence of the respective alleles is strongly determinant of predisposition towards (DRB1*14/DQB1*05 and A*11/DQB1*05) or protection against (B*50/DQB1*02) the disease.

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Increased frequency of HL-A10 in pemphigus vulgaris

Cited by 23 publications

References 0 publications

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris

HLA‐class 1 and class 2 antigens in Turkish patients with pemphigus

Human leukocyte antigens class I and class II in patients with pemphigus in southern Turkey

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