“…BACE1 is concentrated in neuronal presynaptic terminals, 32,33 suggesting an important role for BACE1 at the synapse. Consistent with BACE1 neuronal localisation, recent studies of BACE1 −/− mice have shown complex neurological phenotypes, including axon guidance defects, 34–36 hypomyelination, 37–39 memory deficits, 19,28,30,40,41 muscle spindle reduction, 42 neurochemical deficits, 43 neurogenesis and astrogenesis abnormalities, 44 neurodegeneration with age, 45 spine density reduction, 46 retinal pathology, 47 schizophrenia endophenotypes, 46 and seizures, 40,45,48 among other phenotypes (table 1).…”