Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis

Quantitative proteomics of forebrain subcellular fractions in fragile X mental retardation 1 knockout mice following acute treatment with 2‐Methyl‐6‐(phenylethynyl)pyridine: Relevance to developmental study of schizophrenia

“…The direction of change for all of these proteins was identical to what has been identified in previous proteomic studies of brain tissue from subjects with schizophrenia with the exception of MAPT and PHGDH (Table , Supporting Information Tables S1–S4) providing further relevance for this model to the study of schizophrenia. Additionally, some of these proteins have previously been identified as schizophrenia candidate genes or been found to have altered mRNA or protein expression in non‐proteomics studies including MBP (Ota et al, ), CNP (Voineskos et al, ), and PLP1 (Qin et al, ). Interestingly, with the exceptions of PLP1 in the nuclear fraction and PHGDH in the rER fraction, none of these proteins were also differentially expressed in the Fmr1 KO + MPEP group.…”

Biomarkers and schizophrenia: a qualitative review

“…While longitudinally assessing gene expression in the blood of very early stage drug-naïve FEP patients, NDEL1 and MBP were found to be upregulated [15]. This effect appeared to be attenuated by risperidone treatment [15]. Hence, the authors suggested that both genes NDEL1 and MBP, which are involved in important neuronal processes (neurodevelopment and myelination, respectively), may be putative biomarkers for psychotic disorders [15].…”

“…This effect appeared to be attenuated by risperidone treatment [15]. Hence, the authors suggested that both genes NDEL1 and MBP, which are involved in important neuronal processes (neurodevelopment and myelination, respectively), may be putative biomarkers for psychotic disorders [15].…”

“…Myelin basic protein (MBP) is the only structural myelin protein known to be absolutely required for generating compact myelin sheaths [101]. While longitudinally assessing gene expression in the blood of very early stage drug-naïve FEP patients, NDEL1 and MBP were found to be upregulated [15]. This effect appeared to be attenuated by risperidone treatment [15].…”

“…Research at illness' onset is especially significant, since it avoids the effect of confounding variables [14], such as prior psycho-pharmacological treatment [10]. For example, few studies have investigated the molecular signatures in drug-naïve first episode psychosis (FEP) patients, given the difficulty of collecting biological samples before any antipsychotic drug administration [15]. FEP might be the most critical period of SCZ and possibly the most opportune time for studying key mechanisms that influence treatment response and outcome [10].…”