Increased erythrocyte aggregation following an acute bout of eccentric isokinetic exercise does not exceed two days

Kilic‐Toprak, Emine; Ünver, Fatma; Kilic-Erkek, Ozgen; Korkmaz, Halil; Özdemir, Yasin; Oymak, Burak; Oskay, Alten; Bor-Küçükatay, Melek

doi:10.3233/bir-180175

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…In horses, elevated rouleaux formation has been positively associated with fatal outcomes in colic, whereas, colic patients with lower rouleaux formation have improved clinical outcomes (Andrews et al, 1990). Rouleaux is markedly more prevalent in horses than in humans, pigs, cows or sheep (Weng et al, 1996); it is increased in response to a variety of factors, including acute exercise bouts in horses (Coyne et al, 1990) and humans (Kilic‐Toprak et al, 2018), likely due, at least in part, to increased formation of reactive oxygen species (Panyarachun et al, 2009). Rouleaux tends to decline in response to exercise training in humans (Filar‐Mierzwa et al, 2019; Nader et al, 2018; Sandor et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of a nutraceutical supplement on gastrointestinal health in racing standardbreds

Wellard

Medyk

Pearson

2021

Animal Physiology Nutrition

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Section: Discussionmentioning

confidence: 99%

Effects of a nutraceutical supplement on gastrointestinal health in racing standardbreds

Wellard

Medyk

Pearson

2021

Animal Physiology Nutrition

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“…Hemorheology is a comprehensive indicator of blood flow characteristics. The related indicators such as blood viscosity and coagulation provide a theoretical basis for the diagnosis and treatment of diseases [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Levistilide A on Hemorheology and Endothelial Cell Injury in Rats with Blood Stasis

Liu

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Vascular endothelial cell injury is not only the initiating factor of cardiovascular and cerebrovascular diseases but also the essence of blood stasis. Levistilide A (LA), a natural component isolated from the traditional Chinese herb, Ligusticum chuanxiong Hort, has traditional effects on improving blood circulation and removing stasis. In this study, the effects and potential mechanisms of LA in the rat model of blood stasis and the mechanism in endothelial cell injury have been explored. Materials and Methods. In this experiment, the effects of LA on the model of acute blood stasis in rats were explored. The blood samples were collected for the measurement of coagulation and hemorheological indices, and the carotid arteries were also excised from rats for hematoxylin-eosin (HE) staining and immunohistochemistry (IHC). In addition, the improvement effects of LA on the H2O2-induced human umbilical vein endothelial cell (HUVEC) injury model were evaluated. And the cell viability detection was conducted by the CCK8 assay, and the pathway-related protein expressions were detected by western blotting. Results. In vivo, compared with the model group, the treatment of LA (10 mg/kg) could reduce the FIB (fibrinogen) content ( P < 0.01 ), increase the INR (international normalized ratio) and PT (prothrombin time) ( P < 0.01 ), and reduce the plasma viscosity ( P < 0.05 ) and whole blood viscosities of low, medium, and high shear rates in the blood of blood stasis model rats ( P < 0.01 ). In vitro, the cell viability in the LA-pretreated group was higher than that of the model group ( P < 0.05 ). The expression levels of PI3K, AKT, and eNOs in the LA-pretreated group were increased ( P < 0.01 ) as compared to the model group. Conclusion. These findings demonstrated that LA has the ability to improve blood hypercoagulation and blood viscosity, and enhance the viability of cells. It is more likely that it exerts a protective effect on the endothelial cell through the PI3K-AKT-eNOs pathway. These results indicate LA will be a potential candidate to cure blood stasis with endothelial cell injury.

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“…Under the influence of a single, long-term physical effort, plasma volume decreases by up to 15% (hemoconcentration: increase in hematocrit and blood viscosity, while the total number and volume of erythrocytes do not change substantially) [ 13 ]. A frequently observed effect of intensive physical exercise is a decrease in the erythrocytes’ deformability [ 14 , 15 , 16 ] and an increase in their ability to form blood cell aggregates, which in turn increases blood flow resistance, especially in small blood vessels [ 17 , 18 , 19 ]. The body’s response to regular physical training is an increase in plasma volume, even by 20%, which is associated with a decrease in hematocrit and blood viscosity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Whole-Body Vibration Training on Hemorheological Blood Indices in Young, Healthy Women

Gattner

Adamiak

Piotrowska

et al. 2023

IJERPH

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The aim of the study is to assess the effect of single and 12-week WBVT and training without vibration on changes in hemorheological blood indices and plasma fibrinogen levels in young, healthy women. Three groups are distinguished: the experimental group—participating in WBVT (n = 17); the comparison group—implementing the same physical exercise protocol without the vibration factor (n = 12); and the control group—no intervention (n = 17). In the experimental and comparison group, blood is collected before and after the first and last training, while in the control group, blood is collected twice, 3 months apart. After a series of WBVT, a significant decrease in the mean erythrocyte volume and mean hemoglobin mass in erythrocytes, as well as a slight increase in the mean erythrocyte hemoglobin concentration, is found, and the effect of the last training is a significant decrease in plasma volume. Under the influence of repeated WBVT, there is an increase in erythrocyte deformability at low shear stress and an increase in the aggregation amplitude. The study shows that WBVT improves blood flow in the vessels and does not affect erythrocyte aggregation and the level of fibrinogen, which confirms the safety of this form of exercise.

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Increased erythrocyte aggregation following an acute bout of eccentric isokinetic exercise does not exceed two days

Cited by 3 publications

References 31 publications

Effects of a nutraceutical supplement on gastrointestinal health in racing standardbreds

Effects of a nutraceutical supplement on gastrointestinal health in racing standardbreds

Effects of Levistilide A on Hemorheology and Endothelial Cell Injury in Rats with Blood Stasis

Effect of Whole-Body Vibration Training on Hemorheological Blood Indices in Young, Healthy Women

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