2015
DOI: 10.18632/aging.100859
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Abstract: It has been a long standing hypothesis that blood tissue of PD Parkinson's disease (PD) patients may exhibit signs of accelerated aging. Here we use DNA methylation based biomarkers of aging (“epigenetic clock”) to assess the aging rate of blood in two ethnically distinct case-control data sets. Using n=508 Caucasian and n=84 Hispanic blood samples, we assess a) the intrinsic epigenetic age acceleration of blood (IEAA), which is independent of blood cell counts, and b) the extrinsic epigenetic age acceleration… Show more

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Cited by 301 publications
(274 citation statements)
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References 45 publications
(54 reference statements)
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“…WMH load has been consistently associated with AD; TREM2 hypomethylation and overexpression have been previously observed when comparing blood samples of AD and controls, while increased TREM2 methylation and hydroxymethylation have been observed in AD brain [34][35][36][37][38]. Overall it is likely that previously identified associations between cell composition and Parkinson's disease as well as methylation and expression changes in ABCA7, TREM2 and SNCA with AD and SNCA methylation with dementia with Lewy bodies are specific for those conditions and thus not present in our dataset [27,34,[39][40][41].…”
Section: Resultsmentioning
confidence: 56%
“…WMH load has been consistently associated with AD; TREM2 hypomethylation and overexpression have been previously observed when comparing blood samples of AD and controls, while increased TREM2 methylation and hydroxymethylation have been observed in AD brain [34][35][36][37][38]. Overall it is likely that previously identified associations between cell composition and Parkinson's disease as well as methylation and expression changes in ABCA7, TREM2 and SNCA with AD and SNCA methylation with dementia with Lewy bodies are specific for those conditions and thus not present in our dataset [27,34,[39][40][41].…”
Section: Resultsmentioning
confidence: 56%
“…Our study contributes to an increasing body of evidence suggesting that epigenetic age acceleration is associated with neurodegenerative disorders [22, 51, 52]. Future research will be needed to evaluate to what extent increased epigenetic age acceleration is specific to HD.…”
Section: Discussionmentioning
confidence: 78%
“…This model has been recently supported by studies showing that lifetime stress and stress-related phenotypes may accelerate epigenetic aging (Boks et al, 2015;Brody et al, 2016a;Brody et al, 2016b;Simons et al, 2016;Wolf et al, 2015;Zannas et al, 2015a), a measure associated with several aging-related phenotypes (Horvath et al, 2014;Horvath and Ritz, 2015;Levine et al, 2015a;Levine et al, 2015b;Marioni et al, 2015a;Marioni et al, 2015b;Wolf et al, 2015). These findings have important implications, though we are by no means proposing that all stressrelated increases in aging-related disease can be attributed to epigenetic mechanisms.…”
Section: Resultsmentioning
confidence: 76%
“…Interestingly, epigenetic age acceleration is highly heritable in newborns but shows markedly decreased heritability later in life (Horvath, 2013), suggesting considerable sensitivity of this marker to environmental factors. Furthermore, cumulative evidence supports that accelerated epigenetic aging is associated with a number of aging-related and progeria-type phenotypes, including all-cause mortality in late life (Marioni et al, 2016;Marioni et al, 2015a), physical and cognitive impairment (Levine et al, 2015b;Marioni et al, 2015b;Wolf et al, 2015), cancer incidence and mortality (Zheng et al, 2016), frailty in older ages (Breitling et al, 2016), lung cancer in women (Levine et al, 2015a), Down syndrome , Parkinson's disease (Horvath and Ritz, 2015), and obesity (Horvath et al, 2014).…”
Section: Dna Methylation and Aging-related Phenotypesmentioning
confidence: 99%