Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis

Wang, Chao-Ping; Hsu, Hui-Ling; Hung, Wei‐Chin; Yu, Teng‐Hung; Chen, Yen‐Hsun; Chiu, Chih-Yi; Liu, Lu; Chung, Fu‐Mei; Shin, Shyi–Jang; Lee, Yau-Jiunn

doi:10.1111/j.1365-2265.2008.03411.x

Cited by 196 publications

(190 citation statements)

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“…25 EFV is an important fat depot and its abundance was clearly associated with the presence and severity of coronaropathy. 8,15,40 An inflammatory profile in patients with coronary disease was also enlightened, suggesting a pathophysiological link between EFV and the development or aggravation of coronaropathy. 5,8,9,41 This study provides a detailed characterization of the metabolic, inflammatory and cardiovascular parameters associated with EFV.…”

Section: Discussionmentioning

confidence: 99%

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

et al. 2011

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Objective: To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function. Research design and methods: Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 ± 2.0 kg m À2 ) and 30 obese (BMI: 41.8 ± 6 kg m À2 ) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy. Results: EFV and MTGC were positively correlated (r ¼ 0.52, Po0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141±18 versus 79±7 ml, P ¼ 0.0001; 1.0±0.1 versus 0.6±0.1%, P ¼ 0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213±34 versus 141±18 ml, P ¼ 0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (Po0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (b ¼ À0.38, P ¼ 0.01), suggesting an impact of cardiac steatosis in cardiac function. Conclusions: These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition.

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Section: Discussionmentioning

confidence: 99%

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

et al. 2011

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“…13 Many studies have concluded that EAT is higher in the patients with diabetics, HT and obesity. [6][7][8][21][22][23] DM and HT are closely related with the metabolic syndrome and the two most frequently observed reasons of the increased cardiovascular risk in the general population and the ESRF patients. No study has been recorded yet which addresses uremic factors and its relationship with EAT in the dialysis patients without DM and HT.…”

Section: Discussionmentioning

confidence: 99%

“…5 Various studies point that as a part of metabolic syndrome EAT has increased in both Type 1 and Type 2 diabetes patients and hypertensive patients and that this may be a new cardiovascular risk indicator. [6][7][8][9] However, the number of studies pointing that EAT may be taken as a cardiovascular risk indicator in patients with ESRF is very few. In a small number of recent studies, it has been pointed that EAT and coronary artery calcification score in patients with ESRF has increased in comparison with healthy people.…”

Section: Introductionmentioning

confidence: 99%

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Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

2013

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Turkey AbstractPurpose: It has been found out that the epicardial adipose tissue (EAT) measured by echocardiography is related with various metabolic parameters. Being accepted as the new cardiovascular risk indicator, there have been few studies on EAT in relation to the patients with end-stage renal failure. In our study, we aim to evaluate EAT and carotid intima media thickness (CIMT) in non-diabetic, non-hypertensive hemodialysis (HD) patients. Methods: Our study recruited 47 non-diabetic, non-hypertensive HD patients (22 males, 25 females, median age 54 (44.3-60.8) years) and an age-gender matched control group consisting 41 healthy subjects (17 males, 24 females, median age 52 (48-56) years). In all patients, EAT was measured by echocardiography and CIMT by ultrasonography; and routine laboratory parameters were studied. Results: In our study, we obtained laboratory findings matching with the profiles of uremic patients among HD patients and CIMT values of HD patients are significantly higher than that of the control group

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“…Previous studies using transthoracic echocardiography showed that epicardial adipose tissue thickness measured on the right ventricle correlated with waist circumference, abdominal visceral fat, insulin resistance, metabolic syndrome, and the severity of coronary artery disease [6] [16] [17] [18]. A number of studies using cardiac CT also showed that the amount of epicardial adipose tissue was associated with cardiovascular risk factors, coronary artery calcification, metabolic syndrome, and diabetes, independent of recognized obesity-related indicators such as BMI or waist circumference [19] [20] [21] [22] [23].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Factors and Epicardial Adipose Tissue Measured by Chest Computed Tomography in Healthy Adults

Kim¹,

Lee²

2017

JBM

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Background: Epicardial adipose tissue (EAT) may produce several cytokines contributed to coronary atherosclerosis. EAT was measured by transthoracic echocardiography or 3 dimensional cardiac computed tomography (CT) on previous studies. We aimed to evaluate the correlation between EAT thickness and cardiovascular risk factors in healthy adults. Method: We collected clinical, biochemical information from 469 subjects (371 men and 98 women) who visited our health promotion center. EAT thickness was measured by chest CT on the free wall of the right ventricle. Result: The mean EAT thickness was 2.47 ± 1.64 mm in total of 469 subjects. EAT thickness was significantly correlated to age, weight, body mass index (BMI), total body fat, systolic and diastolic blood pressure, total cholesterol, low density lipoprotein (LDL)-cholesterol, and fasting glucose in men and to age, height, weight, BMI, total body fat, systolic and diastolic blood pressure, triglycerides, C-reactive protein (CRP), and fasting glucose in women. Multivariate analysis showed that age, BMI, systolic blood pressure, fasting glucose were the variables that independently correlated to EAT thickness in men. But there was no significant independent variable in women. Conclusion: In our study, EAT thickness measured with chest CT in healthy individuals correlates with cardiovascular risk factors in men.

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Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis

Cited by 196 publications

References 30 publications

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

Cardiovascular Risk Factors and Epicardial Adipose Tissue Measured by Chest Computed Tomography in Healthy Adults

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