volume 10, issue 10, P2709-2722 2018
DOI: 10.18632/aging.101582
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Justin Darcy, Samuel McFadden, Yimin Fang, Darlene E. Berryman, Edward O. List, Nicholas Milcik, Andrzej Bartke

Abstract: Ames dwarf (Prop1df) mice possess a loss-of-function mutation that results in deficiency of growth hormone, prolactin, and thyroid-stimulating hormone, as well as exceptional longevity. Work in other laboratories suggests that increased respiration and lipid utilization are important for maximizing mammalian longevity. Interestingly, these phenotypes are observed in Ames dwarf mice. We recently demonstrated that Ames dwarf mice have hyperactive brown adipose tissue (BAT), and hypothesized that this may in part…

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