Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal

Buckman, Sam; Hodgson, Stephen R.; Hofford, Rebecca S.; Eitan, Shoshana

doi:10.1016/j.bbr.2008.09.035

Cited by 34 publications

(22 citation statements)

References 26 publications

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“…These results support previous findings that the morphine use develops a feeling of hopelessness, apathy, and anxiousness. [44] In FST and EPM, morphine dependence induced depression and anxiety like symptoms and results of OFT verified this effect. We demonstrated that morphine dependence impairs learning as observed by increased escape latency and traveled distance in MWM test.…”

Section: Discussionmentioning

confidence: 86%

Study of the effects of controlled morphine administration for treatment of anxiety, depression and cognition impairment in morphine-addicted rats

et al. 2016

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Background:Morphine dependency usually results in undesired outcomes such as anxiety, depression, and cognitive alterations. In this study, morphine was used to manage morphine dependence-induced anxiety, depression, and learning and memory disturbances.Materials and Methods:Forty rats were divided equally into five groups. Group 1 received saline for 21 days. Groups 2–5 were dependent by increasing administration of morphine (15–45 mg/kg) for 7 days. For the next 14 days, morphine was administered as the following regimen: Group 2: once daily; 45 mg/kg (positive controls), Group 3: the same dose with an increasing interval (6 h longer than the previous intervals each time), Group 4: the same dose with an irregular intervals (12, 24, 36 h intervals interchangeably), and Group 5: decreasing doses once daily (every time 2.5 mg/kg less than the former dosage). On days 22–26, elevated plus maze (EPM), open field test (OFT), forced swim test (FST), and tail suspension test (TST) were performed to investigate anxiety level and depression in animals. Between 17th and 21st days, Morris water maze (MWM) was used to evaluate the spatial learning and memory.Results:Chronic morphine administration caused depression and anxiety as observed by FST, EPM, and TST and decreased motor activity in OFT and caused impairment in learning and memory performance in MWM. Treatment with our protocol as increasing interval, irregular interval, and decreasing dosage of morphine caused marked reduction in depression, anxiety, and improved cognition performance compared with positive control group; and attenuated motor deficits in morphine-dependent rats, remarkably.Conclusions:Change in dosage regimens of morphine can reduce morphine-induced anxiety, depression, and cognitive impairments.

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Section: Discussionmentioning

confidence: 86%

Study of the effects of controlled morphine administration for treatment of anxiety, depression and cognition impairment in morphine-addicted rats

et al. 2016

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“…The lack of locomotor sensitization the first day of withdrawal following chronic morphine treatment could be due to induction of morphine dependency. However, recent data indicated that some withdrawal signs, used to measure morphine dependence, are transient and disappeared 8 h after the last morphine injection (Buckman et al 2009). …”

Section: Discussionmentioning

confidence: 97%

Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization

et al. 2011

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“…On days 5 and 6, they were injected with 40 mg/kg morphine. This morphine regimen was selected based on both our previous studies (Eitan et al, 2003, Hodgson et al, 2009, Buckman et al, 2009) as well as those of other investigators (el-Kadi and Sharif, 1994, Spanagel et al, 1994, Matthes et al, 1996, Kest et al, 2001, Contet et al, 2008) who have demonstrated that such doses induce significant antinociceptive tolerance, locomotor sensitization, dependence and withdrawal.…”

Section: Methodsmentioning

confidence: 99%

Socially induced morphine pseudosensitization in adolescent mice

Hodgson

Hofford²,

Roberts³

et al. 2010

Behavioural Pharmacology

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Given that social influences are among the strongest predictors of adolescents' drug use, this study examined the effect of social interaction on morphine-induced hyper-locomotion in both adolescent and adult mice. Three experimental groups of adolescent and adult male mice were examined: 1) morphine-treated mice (twice daily, 10-40 mg/kg, s.c.), 2) saline-injected mice housed together with the morphine-treated mice ('saline cage-mates'), and 3) saline-injected mice housed physically and visually separated from the morphine-treated mice ('saline alone'). Following the treatment period, mice were tested individually for their locomotor response to 10 mg/kg morphine (s.c.). Adolescent saline cage-mates, though administered morphine for the very first time, exhibited an enhanced hyper-locomotion response similar to the locomotor sensitization response exhibited by the morphine-treated mice. This was not observed in adults. In adults, there were no significant differences in morphine induced hyper-locomotion between saline alone and saline cage-mates. As expected, morphine-treated adults and adolescents both exhibited locomotor sensitization. These results demonstrate a vulnerability to social influences in adolescent mice which does not exist in adult mice.

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Increased elevated plus maze open-arm time in mice during spontaneous morphine withdrawal

Cited by 34 publications

References 26 publications

Study of the effects of controlled morphine administration for treatment of anxiety, depression and cognition impairment in morphine-addicted rats

Study of the effects of controlled morphine administration for treatment of anxiety, depression and cognition impairment in morphine-addicted rats

Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization

Socially induced morphine pseudosensitization in adolescent mice

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