Increased dietary methionine levels and supplemental L-carnitine do not prevent the development of white striping in broiler chickens

Kuter, Eren; Önol, Ahmet Gökhan

doi:10.1016/j.anifeedsci.2021.115059

Cited by 4 publications

(4 citation statements)

References 69 publications

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“…Additionally, Kalbande et al [ 18 ] indicated that high dietary Meth levels decreased the serum triglyceride concentration, although the serum cholesterol level was unaffected. In contrast, another study showed that dietary methionine levels did not affect serum triglyceride and total cholesterol levels [ 48 ]. The liver produces triglycerides that are transported into the blood as lipoproteins and then released under the effect of lipoprotein lipase (LPL) to be stored in adipocytes or catabolized in tissues [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Nano-Methionine supplementation in drinking water on growth performance, lipid metabolism, and related gene expression in broiler chicken

Shobokshy¹,

Samaha²,

Maksoud³

et al. 2022

J Adv Vet Anim Res

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Objectives: The study aimed to determine how Nano-Methionine (Nano-Meth) affected growth, lipid metabolism, and relative gene expression for acetyl-CoA carboxylase (ACC), fatty acid syn¬thase (FAS), growth hormone receptor (GHR), insulin-like growth factor receptor-1 (IGFR-1), myo¬statin (MSTN), and cholecystokinin (CCK) genes in broiler chickens. Materials and Methods: A total of 100 1-day-old broilers were randomly assigned into 2 groups: 1) the control group received drinking water without any supplements, and 2) the Nano-Meth group received 10 ml/l of 5% Nano-Meth starting from 1 day old until 35 days old (the end of the experiment). Results: Nano-Meth improved final body weight, weight gains, feed intake, and feed conver¬sion ratio. Compared to the control group, Nano-Meth significantly lowered the serum levels of triglyceride, cholesterol, very low-density lipoprotein, and low-density lipoprotein in chickens. Nano-Meth significantly increased the serum levels of total protein, albumin, high-density lipo-protein, and glucose more than the control group. Nano-Meth lowered the mRNA gene expression of ACC, FAS, MSTN, and CCK but increased that of GHR and IGFR-1. Conclusions: We concluded that supplementation with Nano-Meth enhances growth performance and decreases lipid accumulation in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Influence of Nano-Methionine supplementation in drinking water on growth performance, lipid metabolism, and related gene expression in broiler chicken

Shobokshy¹,

Samaha²,

Maksoud³

et al. 2022

J Adv Vet Anim Res

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“…However, many of these strategies were ineffectual (reduced by 10%; Elkin, 2017 ). L-carnitine ( LC ) (β-hydroxy-γ-trimethyl-aminobutyrate, C 7 H 15 NO 3) plays an important role in lipid metabolism and acts as an essential cofactor for the β-oxidation of fatty acids by facilitating the transport of long-chain fatty acids across the mitochondrial membrane as acyl-carnitine esters ( Tekeli, 2019 ; Kuter and Ӧnol, 2021 ; Liu et al, 2021 ). According to reports, LC is a potent antioxidant that protects antioxidant enzymes from oxidative damage ( Canbolat et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of L-carnitine-loaded solid lipid nanoparticles on performance, antioxidant parameters, and expression of genes associated with cholesterol metabolism in laying hens

Eskandani¹,

Navidshad²,

Eskandani³

et al. 2022

Poultry Science

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“…Due to the faster growth of broiler chickens and accumulation of fatty tissue in the major pectoral muscle, it was thought that the development of WS in broiler chickens may be prevented either by slowing down the growth trajectory or by lowering the accumulation of fatty tissue. A recent study reported that increasing the dietary methionine levels or supplemental l ‐carnitine in order to enhance the lipolysis and to reduce the lipogenesis was unable to inhibit or reduce the development of WS in broiler chickens 7 . Unlike this, slowdown of growth trajectory in broiler chickens has shown to reduce the occurrence of WS with their own pros and cons.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study reported that increasing the dietary methionine levels or supplemental L-carnitine in order to enhance the lipolysis and to reduce the lipogenesis was unable to inhibit or reduce the development of WS in broiler chickens. 7 Unlike this, slowdown of growth trajectory in broiler chickens has shown to reduce the occurrence of WS with their own pros and cons. Researchers have made several attempts to slow down the growth of broiler chickens through quantitative feed restriction, 8 and continuous and intermittent restriction of nutrients like metabolizable energy (ME), 9,10 digestible lysine (dLys), [11][12][13] and amino acid (AA) densities.…”

Section: Introductionmentioning

confidence: 99%

Intermittent dilution of dietary digestible lysine lowers the incidence of white striping by suppressing the growth, lipid synthesis, and muscle damage in broiler chickens

et al. 2022

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BACKGROUND White striping (WS) is a myopathy of breast muscle (Pectoralis major) that affects the quality and consumer acceptance of breast fillets of broiler chickens. Previous studies have shown that intermittent dilution of dietary nutrients suppresses the development of WS on the breast muscle of broiler chickens. However, the mechanism by which these interventions reduce the occurrence of WS remains inconclusive. In this study, we adopted intermittent reduction of dietary digestible lysine (dLys) density or metabolizable energy (ME) and amino acid (AA) density using chemical and fatty acid composition of breast fillets, and blood metabolites to understand the mechanism while histopathology and immunohistochemistry of breast muscles were used for confirmation. RESULTS Occurrence of WS was lower in broiler chickens fed 85% dLys diets in comparison with other groups. Crude protein and ether extract in breast meat of 85% dLys groups were greater (P < 0.001) and lower (P = 0.010), respectively. Serum concentrations of lipid metabolites and enzymes were lower in broiler chickens fed 85% dLys diets than control group (P < 0.05). Feeding 85% dLys diets had low degree of myodegeneration and necrosis, inflammation, lipid deposition, infiltration of T‐lymphocyte (CD3+) and macrophages (Iba‐1+), and low expression of heat‐shock protein 70 (HSP70) than other groups (P < 0.001). CONCLUSION Dilution of dietary dLys to 85% of the required quantities reduces the development of WS in broiler chickens by slowing the growth, lipid synthesis, and muscle damage confirmed by lower extent of histopathological lesions. © 2022 Society of Chemical Industry.

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Increased dietary methionine levels and supplemental L-carnitine do not prevent the development of white striping in broiler chickens

Cited by 4 publications

References 69 publications

Influence of Nano-Methionine supplementation in drinking water on growth performance, lipid metabolism, and related gene expression in broiler chicken

Influence of Nano-Methionine supplementation in drinking water on growth performance, lipid metabolism, and related gene expression in broiler chicken

The effects of L-carnitine-loaded solid lipid nanoparticles on performance, antioxidant parameters, and expression of genes associated with cholesterol metabolism in laying hens

Intermittent dilution of dietary digestible lysine lowers the incidence of white striping by suppressing the growth, lipid synthesis, and muscle damage in broiler chickens

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