Biochemical Pharmacology volume 79, issue 10, P1387-1397 2010 DOI: 10.1016/j.bcp.2009.12.023 View full text
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Michal Sabisz, Józefa Węsierska-Gądek, Andrzej Skladanowski

Abstract: Our previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with drug alone. Cytotoxic effect of drug/NU1025 of other topoisomerase II inhibitors …

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