Increased concentrations of the oxidative DNA adduct 7,8-dihydro-8-oxo-2-deoxyguanosine in the germ-line of men with type 1 diabetes

Oxidative deoxyribonucleic acid damage in sperm has a negative impact on clinical pregnancy rate in intrauterine insemination but not intracytoplasmic sperm injection cycles

“…This is in agreement with our previous studies (16,17) and those of others (19,30). Interestingly though, no significant differences in percentage sperm DNA fragmentation between pregnant and nonpregnant groups were found and no threshold values could be identified.…”

The influence of type 1 diabetes mellitus on spermatogenic gene expression

“…Beyond traditional light microscopic analysis of the ejaculate that suggests that DM's effect on semen quality is negligible, molecular investigative techniques have now demonstrated that diabetic men have a significantly higher percentage of sperm with nuclear and mitochondrial DNA fragmentation (1) and that the damage is oxidative in nature (2). Sperm DNA damage is known to be associated with decreased embryo quality, lower implantation rates, and, possibly, the early onset of some childhood diseases (3).…”

Infertile marriage in patients with diabetes mellitus

“…(2008 г.) обнаружили, что у мужчин с СД в головках сперматозоидов фрагментация ДНК хрома-тина определялась в 44% случаев против 27% у мужчин без СД (p<0,05), причем при световом микроскопировании спермо-граммы тех и других существенно не различались [15]. Не-сколько ранее этими же авторами было показано, что при СД1 уровень фрагментации ДНК хроматина чрезвычайно высок и превышает таковой у мужчин с бесплодием, но без СД (53% против 32%; р<0,0001), а также у них повышен уровень деле-ций в митохондриальной ДНК [16].…”