Increased Chromosomal Mutation Rate After Hybridization Between Two Subspecies of Grasshoppers

Shaw, D. D.; Wilkinson, Pat; Coates, D. J.

doi:10.1126/science.6407107

Cited by 78 publications

(40 citation statements)

References 24 publications

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“…One consequence of the intraspecific release of mutator activity is that high levels of rare genetic variants observed in hybrid zones (Hunt and Selander, 1973;Avise and Smith, 1974;Kilpatrick and Zimmerman, 1976;Gould and Woodruff, 1978;Sage and Selander, 1979;Smith, 1979;Moran et a!., 1980;Greenbaum, 1981;Hafner, 1982;Peters, 1982;Barton et aL, 1983) may be due to increased rates of mutation (Woodruff et aL, 1979;Thompson and Woodruff, 1980), although intragenic recombination could also explain these variants (Golding and Strobeck, 1983). Support for increased rates of mutation as the cause of the increased genetic variation in hybrid zones comes from the observation that high frequencies of novel chromosome re-arrangements are observed in hybrid zones of grasshoppers and the re-arrangements are derived only from hybrid parents (Shaw et aL, 1983).…”

Section: Discussionmentioning

confidence: 99%

“…For example, hybridisation among migrants in the large-density winery population might be expected to increase mutation rates by the documented intraspecific hybrid release of mutator activity (Thompson and Woodruff, 1980;Woodruff et a!., 1980;Shaw et a!., 1983). As an indication of the possible impact of hybrid release on the rate of genetic change in nature, Woodruff and Thompson (1982b, and in preparation) have observed that the progeny from 25 of 90 crosses between natural population lines of D. melanogaster have a significantly higher frequency of spontaneous lethal mutations than do the base populations, and similar values have been observed for spontaneous breakage in hybrid progeny.…”

Section: Discussionmentioning

confidence: 99%

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Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

et al. 1984

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SUMMARYTo measure the possible correlation between genetic damage and repair ability in natural populations of a eukaryote, we compared the spontaneous frequency of sex-linked recessive lethal mutations and male recombination, which is associated with DNA transposable element induced chromosome breakage, with DNA repair efficiency in isofemale lines of a winery population of Drosophila melanogaster from Australia. Repair efficiency was measured by maternal effects on ring-X chromosome loss. Significant amounts of genetic variability for spontaneous rates of genetic change and for repair ability were observed in the isofemale lines collected during periods of low and high population density. However, there were no correlations between repair ability and rates of genetic damage. Possible reasons for the absence of correlation are discussed, along with the observations that: (a) the frequency of lethal mutations and ring-X chromosome losses were significantly higher in the small, resident population; (b) the rates of ring chromosome losses and especially lethal mutations are uniform over periods of time; (c) and inbreeding of isofemale lines leads to a reduction of the high spontaneous mutation rates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

et al. 1984

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“…As this phenomenon appears to extend to other organisms (cf. Shaw et al, 1983) and to mutations of small effects (Mackay, 1984), it is feasible that the evolution of parthenogenesis may be accompanied by a rise in VM at least early in its transitional stages.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Mutations for Life‐history Characters in an Obligate Parthenogen

1985

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Abstract.-By allowing mutations to accumulate spontaneously in different lines derived from a single female of an obligately parthenogenetic Daphnia, it has become possible to estimate the rate at which new genetic variance for life-history characters arises as well as to identify the average pleiotropic effects of mutant polygenes. The estimated polygenic mutation rates are quite compatible with those available for sexual organisms. The results are therefore in conflict with the hypothesis that parthenogens compensate for the loss of recombination by elevating the mutation rate. Based on these results, it is argued that the rate of phenotypic evolution may be enhanced as much as five-fold by sexuality. However, if dominance or epistatic gene interactions are of major importance, or if the sensitivity to environmental effects is reduced or the rate of polygenic mutation enhanced under asexuality, the full advantage of sex will not be attained and may even be reversed. Regardless ofthese conditions, it is clear that the mutational rate of production of polygenic variation is sufficient to allow significant rates of phenotypic evolution in purely asexual organisms.

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“…At the narrowest zone (3), no male chromosomal heterozygotes were found. (2) Hybridization might result in an increased chromosomal mutation rate, which could disguise heterozygous weta and reduce the estimates of cline width (Shaw et al 1983;Naveira and Fontdevila 1985;Morgan-Richards 1995). For example, where karyotypes differ in the number of pairs of small autosomes (Zones 1 and 3), duplication of unpaired autosomes in hybrids could produce parental-type karyotypes.…”

Section: Variation In Chromosome Cline Widths Among Five Zonesmentioning

confidence: 99%

A Comparison of Five Hybrid Zones of the Weta Hemideina Thoracica (Orthoptera: Anostostomatidae): Degree of Cytogenetic Differentiation Fails to Predict Zone Width

Morgan‐Richards¹,

Wallis

2003

Evolution

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Abstract. Tension zones are maintained by the interaction between selection against hybrids and dispersal of individuals. Investigating multiple hybrid zones within a single species provides the opportunity to examine differences in zone structure on a background of differences in extrinsic factors (e.g., age of the zone, ecology) or intrinsic factors (e.g., chromosomes). The New Zealand tree weta Hemideina thoracica comprises at least eight distinct chromosomal races with diploid numbers ranging from 2n ϭ 11 (XO) to 2n ϭ 23 (XO). Five independent hybrid zones were located that involve races differing from one another by a variety of chromosomal rearrangements. The predicted negative correlation between extent of karyotypic differentiation (measured in terms of both percent of genome and number of rearrangements) and zone width was not found. Conversely, the widest zones were those characterized by two chromosome rearrangements involving up to 35% of the genome. The narrowest zone occurred where the two races differ by a single chromosome rearrangement involving approximately 2% of the genome. The five estimates of chromosomal cline width ranged from 0.5 km to 47 km. A comparative investigation of cline width for both chromosomal and mitochondrial markers revealed a complex pattern of zone characteristics. Three of the five zones in this study showed cline concordance for the nuclear and cytoplasmic markers, and at two of the zones the clines were also coincident. Zones with the widest chromosomal clines had the widest mitochondrial DNA clines. It appears that, even within a single species, the extent of karyotypic differentiation between pairs of races is not a good predictor of the level of disadvantage suffered by hybrids.

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Increased Chromosomal Mutation Rate After Hybridization Between Two Subspecies of Grasshoppers

Cited by 78 publications

References 24 publications

Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

Variation in spontaneous mutation and repair in natural population lines of Drosophila melanogaster

Spontaneous Mutations for Life‐history Characters in an Obligate Parthenogen

A Comparison of Five Hybrid Zones of the Weta Hemideina Thoracica (Orthoptera: Anostostomatidae): Degree of Cytogenetic Differentiation Fails to Predict Zone Width

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