Increased bioavailability of hydrocortisone dissolved in a cream base

Greive, Kerryn A; Barnes, Tanya M

doi:10.1111/ajd.12128

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…Adverse effects are rare if topical corticosteroids are used correctly and according to established recommendations and guidelines. However, misuse or prolonged use of topical corticosteroids may cause some adverse effects [ 36 , 38 , 90 , 91 ]. To reduce the risk, the least potent corticosteroid should be used for the shortest time, while still maintaining effectiveness.…”

Section: The Contributions Of Corticosteroids To Topical Antifungal-c...mentioning

confidence: 99%

Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations

Mijaljica¹,

Spada²,

Harrison³

2022

JoF

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A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections. Their many benefits, owing to their specific mechanism of action, include their ability to target the site of infection, enhance treatment efficacy and reduce the risk of systemic side effects. Their proven efficacy, and positioning in the treatment of fungal skin infections, is enhanced by high patient compliance, especially when appropriate vehicles such as creams, ointments and gels are used. However, inflammation as a result of fungal infection can often impede treatment, especially when combined with pruritus (itch), an unpleasant sensation that elicits an urge to scratch. The scratching that occurs in response to pruritus frequently accelerates skin damage, ultimately aggravating and spreading the fungal infection. To help overcome this issue, a topical antifungal-corticosteroid combination consisting of miconazole or terbinafine and corticosteroids of varying potencies should be used. Due to their inherent benefits, these topical antifungal-corticosteroid combinations can concomitantly and competently attenuate inflammation, relieve pruritus and treat fungal infection.

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Section: The Contributions Of Corticosteroids To Topical Antifungal-c...mentioning

confidence: 99%

Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations

Mijaljica¹,

Spada²,

Harrison³

2022

JoF

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“…Choosing a corticosteroid with appropriate potency plus the appropriate topical formulation should be based on the disease severity and area affected, and the patient's preference and age [88]. Lower potency corticosteroids such as hydrocortisone should be used on the face, intertriginous areas, and areas that are susceptible to steroid atrophy (e.g., forearms) [88,89]. In adults, higher potency corticosteroids such as clobetasone butyrate and mometasone furoate are generally recommended as initial therapy [86,88,90].…”

Section: Corticosteroidsmentioning

confidence: 99%

Topical Moisturisers for the Management of Psoriasis Vulgaris

Mijaljica¹,

Spada²,

Harrison³

2022

Psoriasis - New Research

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The aim of this chapter is to provide an overview of basic and tailored topical moisturisers and discuss how and why they form the backbone for the management of psoriasis. Our discussion begins by describing the main characteristics of psoriasis and by indicating how alterations in the skin’s integrity and barrier function contribute to the initial development of psoriasis and subsequent changes in psoriasis phenotype. Next, we address the evolution of topical moisturisers to ever more sophisticated and beneficial products, and describe the key biophysical effects exerted on the psoriatic skin by their active ingredients, as well as the myriad benefits offered by fundamental and specialty ingredients. Furthermore, we delineate how topical moisturiser formulation modalities can help to improve compromised skin barrier function and to alleviate the symptoms of psoriasis, cosmetically and/or therapeutically as well as discuss the associated concerns and challenges encountered along the way.

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“…16 MF hydrogel was applied to the inner forearm at a rate of 4 mg/cm 2 . Measurements were taken at t = 0 (pre-application) and at 2, 4, 6 and 24 h post-application using a TEWA Meter (Model TM 210 TEWA Meter, Courage and Khazaka, Cologne, Germany) at five different points on the skin, giving a total of 50 points.…”

Section: Tewlmentioning

confidence: 99%

“…16 The same participants who had enrolled into the TEWL study also participated in the skin hydration study. MF hydrogel was applied to the inner forearm at a rate of 4 mg/cm 2 .…”

Section: Skin Hydrationmentioning

confidence: 99%