Increased antimutagenic activity of simple substituted phenols mixed with the hindered phenolic antioxidant dibunol

Scientific Opinion on the use of Resorcinol as a food additive

“…Treatment of mice with resorcinol did not induce micronuclei in bone marrow cells at a dose of 75 mg/kg bw (Paschin et al, 1986) and at 2 equal doses of 250 mg/kg bw separated by an interval of 24 hours (the bone marrow was sampled 6 hours after the second dose) (Hossack and Richardson, 1977); however, the validity of these studies is insufficient due to the sampling times used.…”

Scientific Opinion on the use of Resorcinol as a food additive

“…Treatment of mice with resorcinol did not induce micronuclei in bone marrow cells at a dose of 75 mg/kg bw (Paschin et al, 1986) and at 2 equal doses of 250 mg/kg bw separated by an interval of 24 hours (the bone marrow was sampled 6 hours after the second dose) (Hossack and Richardson, 1977); however, the validity of these studies is insufficient due to the sampling times used.…”

Butylhydroxytoluol (BHT) [MAK Value Documentation in German language, 2004]

“…Es liegen mehrere Studien zur chromosomenschädigenden Wirkung an Säugern vor, in denen BHT weder die Häufigkeit von Mikronuklei im Knochenmark (Bruce und Heddle 1979;Paschin et al 1986) oder im peripheren Blut (Karamova et al 1997) von Mäusen noch die von Chromosomenaberrationen im Knochenmark von Mäusen (Masubuchi et al 1976) oder Ratten (FDA 1972Kawachi et al 1980;Masubuchi et al 1976;Maxwell und Newell 1974) beeinflusste.…”

Resorcinol [MAK Value Documentation, 2003]

“…Groups of 4 male mice were given single intraperitoneal injections of resorcinol in doses of 37.5, 75, 150 or 300 mg/kg body weight and were examined after 24 and 48 hours (Darroudi and Natarajan 1983). In another micronucleus test, the bone marrow of groups of 5 mice per examination time (24, 48, 72 and 96 hours) was examined after a single intraperitoneal resorcinol dose of 75 mg/kg body weight (Paschin et al 1986). Resorcinol was administered to groups of 5 male and 5 female Sprague-Dawley (CFY) rats by gavage of two doses of 250 mg/kg body weight, 24 hours apart.…”

Scientific Opinion on the use of Resorcinol as a food additive

“…Treatment of mice with resorcinol did not induce micronuclei in bone marrow cells at a dose of 75 mg/kg bw (Paschin et al, 1986) and at 2 equal doses of 250 mg/kg bw separated by an interval of 24 hours (the bone marrow was sampled 6 hours after the second dose) (Hossack and Richardson, 1977); however, the validity of these studies is insufficient due to the sampling times used.…”

Butylhydroxytoluol (BHT) [MAK Value Documentation in German language, 2004]

“…Es liegen mehrere Studien zur chromosomenschädigenden Wirkung an Säugern vor, in denen BHT weder die Häufigkeit von Mikronuklei im Knochenmark (Bruce und Heddle 1979;Paschin et al 1986) oder im peripheren Blut (Karamova et al 1997) von Mäusen noch die von Chromosomenaberrationen im Knochenmark von Mäusen (Masubuchi et al 1976) oder Ratten (FDA 1972Kawachi et al 1980;Masubuchi et al 1976;Maxwell und Newell 1974) beeinflusste.…”

Resorcinol [MAK Value Documentation, 2003]

“…Groups of 4 male mice were given single intraperitoneal injections of resorcinol in doses of 37.5, 75, 150 or 300 mg/kg body weight and were examined after 24 and 48 hours (Darroudi and Natarajan 1983). In another micronucleus test, the bone marrow of groups of 5 mice per examination time (24, 48, 72 and 96 hours) was examined after a single intraperitoneal resorcinol dose of 75 mg/kg body weight (Paschin et al 1986). Resorcinol was administered to groups of 5 male and 5 female Sprague-Dawley (CFY) rats by gavage of two doses of 250 mg/kg body weight, 24 hours apart.…”

Scientific Opinion on the use of Resorcinol as a food additive

“…Treatment of mice with resorcinol did not induce micronuclei in bone marrow cells at a dose of 75 mg/kg bw (Paschin et al, 1986) and at 2 equal doses of 250 mg/kg bw separated by an interval of 24 hours (the bone marrow was sampled 6 hours after the second dose) (Hossack and Richardson, 1977); however, the validity of these studies is insufficient due to the sampling times used.…”

Butylhydroxytoluol (BHT) [MAK Value Documentation in German language, 2004]

“…Es liegen mehrere Studien zur chromosomenschädigenden Wirkung an Säugern vor, in denen BHT weder die Häufigkeit von Mikronuklei im Knochenmark (Bruce und Heddle 1979;Paschin et al 1986) oder im peripheren Blut (Karamova et al 1997) von Mäusen noch die von Chromosomenaberrationen im Knochenmark von Mäusen (Masubuchi et al 1976) oder Ratten (FDA 1972Kawachi et al 1980;Masubuchi et al 1976;Maxwell und Newell 1974) beeinflusste.…”

Resorcinol [MAK Value Documentation, 2003]

“…Groups of 4 male mice were given single intraperitoneal injections of resorcinol in doses of 37.5, 75, 150 or 300 mg/kg body weight and were examined after 24 and 48 hours (Darroudi and Natarajan 1983). In another micronucleus test, the bone marrow of groups of 5 mice per examination time (24, 48, 72 and 96 hours) was examined after a single intraperitoneal resorcinol dose of 75 mg/kg body weight (Paschin et al 1986). Resorcinol was administered to groups of 5 male and 5 female Sprague-Dawley (CFY) rats by gavage of two doses of 250 mg/kg body weight, 24 hours apart.…”