Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil

Lorenzoni, Vinícius Victor; Rubert, Franciéli da Costa; Rampelotto, Roberta Filipini; Hörner, Rosmari

doi:10.1590/0037-8682-0362-2017

Cited by 10 publications

(10 citation statements)

References 11 publications

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“…In this study, K. pneumoniae showed varying levels ranging from susceptibility and resistance towards the tested antibiotics. Antibiotic resistance profiles of the isolates using disk diffusion method indicated that resistance to imipenem was 24.6% that was similar to Ghaffarian study (23.3%) in 2018 (21) as well as Khodadadian (25.6%) in 2018 (19), but it was lower than the finding of other studies conducted by Rajabnia (52%) in 2015 (22) Lorenzoni (29.7%) in 2018 (23). Our results proved that meropenem and imipenem remain effective drugs against K. pneumoniae isolates.…”

Section: Discussionsupporting

confidence: 67%

Detection of VIM-1, VIM-2 and IMP-1 metallo- β-lactamase genes in Klebsiella pneumoniae isolated from clinical samples in Sanandaj, Kurdistan, west of Iran

Bahmani¹

2019

IJM

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Background and Objectives: Klebsiella pneumoniae is an important cause of serious nosocomial infections among Gram-negative bacteria. The aim of this study was evaluating the prevalence of VIM-1, VIM-2, and IMP-1 metallo-β-lact- amase genes in clinical specimens at two teaching hospitals in Sanandaj, Kurdistan west of Iran. Materials and Methods: Four hundred different clinical specimens were collected from hospitalized patients or referred to hospitals from May 2013 to March 2014 in Sanandaj, Kurdistan, Iran. MBLs – producing K. pneumoniae detected by Double Disk Synergy Test. The MBL positive isolates were examined for the presence of VIM-1, VIM-2 and IMP-1 genes using PCR technique. Results: Of four hundred clinical specimens, 114 K. pneumoniae isolates were identified. Twenty-eight (24.6%) isolates were resistant to imipenem and 15 strains (53.6%) were positive for MBL enzymes production. PCR results showed VIM-1 and IMP-1 genes frequencies are 4 (26.7%) and 1 (6.7%). Only one strain of K. pneumoniae was found to be MBL producer among the outpatients. Conclusion: The study results exhibited a high level of resistance to most of the antibiotics tested and high prevalence of MBLs producing in K. pneumoniae at two hospitals. Thus, the infection control methods and the implementation of antibiotic agents should be taken into account.

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Section: Discussionsupporting

confidence: 67%

Detection of VIM-1, VIM-2 and IMP-1 metallo- β-lactamase genes in Klebsiella pneumoniae isolated from clinical samples in Sanandaj, Kurdistan, west of Iran

Bahmani¹

2019

IJM

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“…A study assessed the 1805 Klebsiella pneumoniae isolates from the Hospital Universitário de Santa Maria, Brazil for antimicrobial susceptibility profile. Resistance to colistin (239.3%), ciprofloxacin (64%), and amikacin (21.4%) was found increased [1]. In the present study, the sensitivity rate was the highest against amikacin.…”

Section: Resultssupporting

confidence: 46%

“…In recent years, antibiotics have been used to treat diseasecausing bacteria. Antimicrobial resistance is a global threat to public health [1][2][3]. Enzymatic modification (b-lactamases), reduced permeability (selective blockage), increased membrane transport (efflux pumps), altered binding site (specific receptors) and metabolic bypass are the mechanisms of antibiotic resistance in bacteria [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…K. pneumoniae produces various pathogenic virulence factors, including capsular polysaccharide, lipopolysaccharide, fimbriae, siderophores and resistance [14][15][16]. Increased global infections by multidrug-resistant bacteria closely associated with limited drug treatments imply the failure of empirical treatments and strengthen the need for antibacterial therapies based on antimicrobial sensitivity tests [1,17,18] Several studies have demonstrated outbreaks in hospitals due to K. pneumoniae resistant to cephalosporins, aminoglycosides and quinolones of third generation [10]. Therefore, this study aimed to investigate the antimicrobial susceptibility profile of Klebsiella pneumoniae isolates collected during the period of January 2016 till December 2017 at Ziaee Hospital in Ardakan.…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017

Ayatollahi¹,

Sharifyazdi²,

Fadakarfard³

et al. 2020

Iberoam J Med

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Background: In recent years, due to the inappropriate use of antibiotics, drug resistance has increased in gram negative bacilli, including Klebsiella pneumoniae. Drug resistance is associated with an increase in mortality and therapeutic costs. Therefore, determination of an antibiotic resistance pattern for choosing the appropriate treatment for infections caused by this bacterium seems necessary. This study was conducted to determine the antibiotic resistance pattern of Klebsiella pneumoniae species isolated from patients referring to Ziaee Hospital in Ardakan in 2016-2017. Materials and Methods: For this descriptive-analytic study, all positive cultures of Klebsiella pneumoniae in patients referred to Ziaee Hospital in Ardakan during 2016 to 2017, were evaluated. Antibiotic resistance patterns of the samples were determined by the standard method of propagation of the disk from 12 different antibiotics and data analyzed by SPSS 21 software. Results and discussions: The results of this study, which were performed on 75 samples, showed that 22 (29.3%) were male and 53 (70.7%) were female. Klebsiella's resistance to clarithromycin was 100%, but was 100% susceptible to amikacin. The percentage of Klebsiella's resistance to ampicillin was 78.3%, cefalotin 75%, cotrimoxazole 43.9%, ceftriaxone 32%, ciprofloxacin 30.9%, cefotaxime 24%, and ampicillin 20%. The highest sensitivity of Klebsiella pneumoniae for antibiotics was 100% for amikacin, 82.8% for meropenem and 82% for cefepime. Due to the high prevalence of resistance in Klebsiella samples, there is a need for strict measures in the administration of antibiotics. Antibiotic resistance can also be reduced by choosing the appropriate antibiotic for treatment and by taking antibiotic susceptibility tests.

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“…, Goiânia, v. 47, p. [1][2][3][4][5][6][7][8][9][10][11]2020 Introdução A resistência aos antimicrobianos é um problema de saúde pública emergente, infecções que eram tratadas com relativa facilidade podem voltar a matar cerca de 10 milhões de pessoas até 2050 1 . As bactérias que possuem resistência a três ou mais classes de antimicrobianos são denominadas multirresistentes (MDRs) 2 .…”

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Detecção Fenotípica De Bactérias Gram-Negativas Produtoras De Carbapenemases Em Efluente Hospitalar Na Amazônia No Estado Do Pará, Brasil.

Ribeiro

Oliveira

Melo

et al. 2020

EVS

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A resistência a antimicrobianos é um problema de saúde pública emergente, infecções que eram tratadas com relativa facilidade podem voltar a matar cerca de 10 milhões de pessoas até 2050. Elementos móveis transferidos horizontalmente são associados à disseminação de genes de resistência a antibióticos em ambiente hospitalar e microbiota ambiental. Determinar as características fenotípicas de resistência aos antimicrobianos de bactérias gram-negativas isoladas em efluente hospitalar em um hospital de média e alta complexidade na Amazônia. Trata-se de um estudo do tipo descritivo, realizado em um hospital que presta serviços de média e alta complexidade. As coletas contaram com uma amostra diária de antes e após o tratamento do esgoto, o que resultou em 50 análises. A detecção fenotípica e perfil de suscetibilidade foram realizados seguindo métodos já validados. Das 50 amostras analisadas, todas apresentaram crescimento ≥ 105 UFC/ml. Com maior frequência antes do tratamento foram detectados Klebsiella ozaenae (n=6), Citrobacter diversus (n=5) e Escherichia coli (n=4). Já após o tratamento, foram detectados com maior frequência isolados de Klebsiella ozaenae (n=8), P. aeruginosa (n=3), Salmonella sp. (n=3) e A. baumannii (n=1). Foram detectadas cinco cepas produtoras de Carbapenemases no teste fenotípico, apresentando CIM para imipenem e meropenem ≥ 32mcg/ml. Foi possível detectar a presença de bactérias gram-negativas que fenotipicamente expressaram a presença de carbapenemases. Cabe ressaltar que se disseminados para o meio ambiente essas bactérias podem alterar a microbiota ambiental e causar grandes danos à saúde das pessoas que utilizam recursos naturais.

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Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil

Cited by 10 publications

References 11 publications

Detection of VIM-1, VIM-2 and IMP-1 metallo- β-lactamase genes in Klebsiella pneumoniae isolated from clinical samples in Sanandaj, Kurdistan, west of Iran

Detection of VIM-1, VIM-2 and IMP-1 metallo- β-lactamase genes in Klebsiella pneumoniae isolated from clinical samples in Sanandaj, Kurdistan, west of Iran

Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017

Detecção Fenotípica De Bactérias Gram-Negativas Produtoras De Carbapenemases Em Efluente Hospitalar Na Amazônia No Estado Do Pará, Brasil.

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