Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

Catalán, Victoria; Gómez-Ambrosi, Javier; Rodríguez, Amaia; Ramírez, Beatriz; Silva, C.; Rotellar, Fernando; Gil, Marı́a J.; Cienfuegos, Javier A.; Salvador, Javier; Frühbeck, Gema

doi:10.1007/s00109-009-0486-8

Cited by 170 publications

(130 citation statements)

References 47 publications

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“…Biochemical assays of subjects included in the study were measured as previously described [43]. Intra-and interassay coefficients of variation were 5.0 and 4.5%, respectively.…”

Section: Blood Assaysmentioning

confidence: 99%

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Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Catalán

Gómez-Ambrosi

Rodríguez

et al. 2010

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine with physiological effects on the control of glucose homeostasis as well as potentially involved in inflammation. The association of circulating NAMPT concentrations with obesity has not been clearly established. The aim of the present work was to evaluate the effect of obesity on circulating concentrations and gene expression levels of NAMPT in human peripheral blood cells (PBCs) as well as its involvement in inflammation, glucose and lipid metabolism.

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“…Biochemical assays of subjects included in the study were measured as previously described [43]. Intra-and interassay coefficients of variation were 5.0 and 4.5%, respectively.…”

Section: Blood Assaysmentioning

confidence: 99%

“…The transcript levels for NAMPT and HIF1-« were quantified by Real-Time PCR (7300 Real-Time PCR System, Applied Biosystem, Foster City, CA, USA) as previously described [43]. Primers and probes (Supplementary Table 1) were designed using the software Primer Express 2.0 (Applied Biosystems).…”

Section: Rna Extraction and Real-time Pcrmentioning

confidence: 99%

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Catalán

Gómez-Ambrosi

Rodríguez

et al. 2010

Nutrition, Metabolism and Cardiovascular Diseases

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“…Further, recent evidence demonstrates that circulating and local levels of the neurotrophins, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are also produced by adipose tissue (18,19,(34)(35)(36)(37), are altered in human coronary atherosclerosis including in subEAT (36) (Figure 4), also in metabolic syndrome (36) and acute coronary syndromes (38). Of note, one our team (LA) provided clinical results of the therapeutic contribution of NGF in skin and corneal wound healing (39) and this raises a pressing question of whether this may also be the case with a vascular wound, that is, the atherosclerotic plaque (6).…”

Section: Pericardiummentioning

confidence: 99%

“…A novel piece in the puzzle of breast cancer is that NGF (18,19,(34)(35)(36)(37) stimulates breast cancer cell proliferation (51; cf. 52 for BDNF and neurotrophin 4/5).…”

Section: Vasoconstrictorsmentioning

confidence: 99%

“…In recent years, the study of adipobiology has become dominated by an apparently increasing list of adipokines implicated in the control of a wide array of physiological and pathological processes (1,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) including atherogenesis-related processes such as inflammation and vascular tone (21-27). As indicated above, obese adipose tissue is featured by adipocyte hypertrophy leading to hypoxia (16) and invasion of immune cells (4,5); this results in an increased production of pro-inflammatory adipokines.…”

Section: Introductionmentioning

confidence: 99%

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Adipoparacrinology: an Emerging Field in Biomedical Research

Chaldakov¹,

Tunçel²,

Bełtowski³

et al. 2012

Balkan Med J

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Plasmatic lipocalin‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency

et al. 2020

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Lipocalin‐2 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross‐sectional study was to compare LCN2 plasmatic levels in these clinical settings, whereas the secondary objective was to investigate any possible correlation between LCN2 and BMI and/or indexes of insulin sensitivity/resistance. Seventy‐four patients were divided as follows: Group A, MetS (18 patients, 13 females and 5 males, mean ± SEM age 45.1 ± 4.11 years, BMI 31.22 ± 1.73 kg/m2); Group B, total GHD (18 patients, 8 females and 10 males, age 52.44 ± 2.61 years, BMI 30.49 ± 1.87 kg/m2); Group C, Partial GHD (pGHD; 19 patients, 13 females and 6 males, age 48.63 ± 2.19 years, BMI 29.11 ± 1.85 kg/m2); Group D, Controls (19 patients, 13 females and 6males, age 40.26 ± 2.87 years, BMI 23.25 ± 0.95 kg/m2). They were evaluated for glucose and insulin, HOMA‐index, QUICKI‐index, Total/low‐density lipoprotein/high‐density lipoprotein cholesterol, triglycerides, uric acid, IGF‐1, and LCN2. LCN2 plasmatic levels were significantly increased in MetS, while no significant differences with controls were found in total and pGHD. LCN2 levels did not correlate with BMI. A significant positive correlation between LCN2 and HOMA‐index was found in controls, while a trend‐like, yet not significant, a positive correlation was observed in pGHD. Our data show an increase in LCN2 plasmatic levels in MetS. Different inflammatory patterns characterize MetS and GHD. The correlation between HOMA index and LCN2 in normal subjects and possibly in pGHD ones suggests a modulatory action of LCN2 on insulin resistance.

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Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans

Cited by 170 publications

References 47 publications

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Adipoparacrinology: an Emerging Field in Biomedical Research

Plasmatic lipocalin‐2 levels in chronic low‐grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency

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