Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease

Vargas-Rojas, María Inés; Ramírez‐Venegas, Alejandra; Limón-Camacho, Leonardo; Ochoa, Leticia; Hernández-Zenteno, Rafael de Jesús; Sansores, Raúl H

doi:10.1016/j.rmed.2011.05.017

Cited by 139 publications

(126 citation statements)

References 39 publications

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“…The influence of smoke on leukocyte cell numbers and cell function has been demonstrated in several previous studies and our results are consistent with these findings [9,[32][33][34][35]. On the contrary, data concerning the influence of smoking on lymphocyte subpopulations are conflicting [35][36][37][38]. This may be due to the age of the population recruited, smoking habits, healthy status, etc.…”

Section: Variablessupporting

confidence: 91%

“…Changes in lymphocyte subpopulations may reflect progressive changes from non-smokers to healthy smokers to patients with COPD. Very interesting are the data reported by Vargas-Rojas and collaborators showing a polarisation of Th17 cells and their balance with Th1/Th2 and Treg subpopulations in COPD and current smokers, with Th17 and Treg cells showing a progressive increase from healthy subjects to current smokers to COPD group [38].…”

Section: Variablesmentioning

confidence: 95%

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Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Andreoli¹,

Bassi²,

Gregg³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Despite the well-documented role of cigarette smoke in the development of chronic obstructive pulmonary disease (COPD), lung cancer and cardiovascular disease, biomarkers for screening or monitoring disease progression and outcome remain elusive, particularly for COPD and lung cancer. Inflammatory cells and mediators are likely to be involved in the disease processes, but their importance is still poorly understood. The purpose of this study was to investigate early changes in immunological markers associated with smoking in healthy monozygotic twins without a detectable disease discordant for smoking, thereby minimising data variability due to genetic background. Methods: Twenty-two monozygotic twin pairs, aged 31.5 ± 6.3 years, entered the study. One of each twin pair was a smoker and the other a non-smoker. None of the subjects reported any diseases or clinically defined respiratory symptoms or airflow limitation. Each subject donated blood samples for determination of total leukocytes and subpopulations, lymphocyte subpopulation plus pro-inflammatory mediators (interleukin-8, tumour necrosis factor-α, soluble tumour necrosis factor-α receptors and C-reactive protein). Results: We observed a significant increase in the number of circulating leukocytes and neutrophils in smokers compared to non-smokers. Smokers also had significantly higher numbers of B cells and CD4 + T cells, plus an increased CD4/CD8 ratio. The numbers of NK cells were statistically significant lower in smokers compared to non-smokers.

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Section: Variablessupporting

confidence: 91%

Section: Variablesmentioning

confidence: 95%

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Andreoli¹,

Bassi²,

Gregg³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…42,43 The function of Th17 in COPD is less known; an enhancement of Th17 differentiation was observed in peripheral blood and bronchial biopsies of COPD patients compared to those of healthy control. 44,45 We found that CD4 T cells in sγcTg mice were much more skewed to Th17 compared to WT mice with CSE treatment, indicating that more IL-17 production from increased Th17 cell differentiation may recruit more inflammatory responsible cells in COPD. Indeed, IL-17 may induce chemokine secretion [46][47][48] and promote the infiltration of neutrophils and macrophages to peripheral airway.…”

Section: Discussionmentioning

confidence: 85%

Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice

Lee

et al. 2017

COPD

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Cigarette smoking (CS) is a major cause of considerable morbidity and mortality by inducing lung cancer and COPD. COPD, a smoking-related disorder, is closely related to the alteration of immune system and inflammatory processes that are specifically mediated by T cells. Soluble common gamma chain (sγc) has recently been identified as a critical regulator of the development and differentiation of T cells. We examined the effects of sγc in a cigarette smoke extract (CSE) mouse model. The sγc level in CSE mice serum is significantly downregulated, and the cellularity of lymph node (LN) is systemically reduced in the CSE group. Overexpression of sγc enhances the cellularity and IFNγ production of CD8 T cells in LN and also enhances Th1 and Th17 differentiation of CD4 T cells in the respiratory tract. Mechanistically, the downregulation of sγc expression mediated by CSE is required to prevent excessive inflammatory T cell responses. Therefore, our data suggest that sγc may be one of the target molecules for the control of immunopathogenic progresses in COPD.

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“…Además, en los pacientes con EPOC grave se ha observado una alta expresión de IL-18, citoquina que promueve el desarrollo de las células Th1 74 . En cuanto a las células Th17, las cuales están implicadas en procesos autoinmunes y en el reclutamiento de otras células inflamatorias a tejidos 75 , se encuentran incrementadas en sangre de enfermos de EPOC en comparación a fumadores control 76 . Por otro lado, también se ha reportado un incremento de células que expresan IL-17A (una de las principales interleuquinas producidas por las células Th17) en submucosa de pacientes con EPOC 72 .…”

Section: Los Linfocitos T Cd4unclassified

Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica

Montés

García‐Valero³

et al. 2015

Rev. méd. Chile

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Approximately 3 million people in the world die every year as a consequence of COPD, which is associated with an abnormal inflammatory response of the lung to noxious particles and gases. This inflammatory pattern causes pathological changes leading to a narrowing of small airways and destruction of lungjordiog82@gmail.com L a enfermedad pulmonar obstructiva crónica (EPOC) es un proceso patológico de alta prevalencia, considerado en la actualidad la cuarta causa de muerte en el mundo y que, se estima, se convertirá en la tercera en el año 2030 1 . En los países de América Latina, 35 de cada 1.000 hospitalizaciones se deben a la EPOC, con un alto coste económico y con rangos de mortalidad intrahospitalaria que van de 6,7% a 29,5% 2 . En Chile, las enfermedades respiratorias constituyen la tercera causa de muerte y, entre ellas, la EPOC ocupa el segundo lugar, representando a 22% de los decesos 3 . Por su parte, el Proyecto Latinoamericano de Investigación en Obstrucción Pulmonar (PLATINO) ha reportado que la prevalencia de la EPOC en Santiago de Chile es de 6,3% en la población mayor de 40 años 4 . La EPOC se define como una enfermedad caracterizada por una limitación al flujo aéreo no completamente reversible, progresiva y que se asocia a una respuesta inflamatoria anormal de los pulmones a partículas nocivas o gases 5 . Esta enfermedad comprende tanto los síntomas clínicos de la bronquitis/bronquiolitis crónica como los de la patología derivada del enfisema pulmonar. La confirmación diagnóstica se obtiene al realizar pruebas espirométricas, las cuales permiten determinar la obstrucción del flujo aéreo y el grado de alteración de la función pulmonar a partir del volumen espirado forzado en el primer segundo (VEF 1 ), la capacidad vital forzada (CVF) y la relación de estos dos parámetros clínicos (VEF 1 /CVF) 5 . Se considera al humo del tabaco como el prin-

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Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease

Abstract: The increase of Th17 response and the lost of balance between CD4(+) T cell subsets, suggest a lack of regulation of the systemic inflammatory response that may contribute to pathogenesis in COPD patients.

Cited by 139 publications

References 39 publications

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice

Efectores celulares de la respuesta inflamatoria en la enfermedad pulmonar obstructiva crónica

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