Inclusion complex of GA-13316 with β-cyclodextrin: Preparation, characterization, molecular modeling, and in vitro evaluation

Yang, Rui; Xiao, Chuan-Fan; Liu, Zhi-Cheng; Gao, Zhan-Yong; Yan, Sheng‐Jiao; Zhang, Jihong; Zhang, Hongbin; Lin, Jun

doi:10.1016/j.carbpol.2014.05.021

Cited by 27 publications

(7 citation statements)

References 18 publications

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“…However, 3 weeks of storage of the CIs in a culture medium at 4 °C had no notable effect on cell viability. This result supported the findings of a previous report by Yang et al [ 35 ], who demonstrated that the cytotoxicity of a target compound decreased after β-CD inclusion. Therefore, the t CIN and β-CD inclusion complex may have an important role in maintaining the stability of functional foods.…”

Section: Resultssupporting

confidence: 93%

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

Davaatseren

Hong

et al. 2017

Molecules

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trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.

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Section: Resultssupporting

confidence: 93%

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

Davaatseren

Hong

et al. 2017

Molecules

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“…These advantages serve to increase therapeutic efficacy and reduce local and systemic adverse effects. 17 Thus, the purpose of this study was to assess the clinical outcomes following the treatment of periodontitis with 10% DOX encapsulated in β-CD gel, and with pure 10% DOX in the gel. The hypothesis was that the inclusion compound would increase the mucoadhesiveness of the gel and the encapsulation of DOX in β-CD, enhancing the drug's local effects.…”

Section: Introductionmentioning

confidence: 99%

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

et al. 2019

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This clinical trial compared the efficacy of doxycycline (DOX) in β-cyclodextrin (DOX)/βCD) with DOX-alone in gel on thirty-three subjects with periodontitis. Patients were randomized to group 1 GI; 10% DOX + scaling and root planning (SRP); group 2 (GII (10% DOX /β-CD + SRP), and group 3 (GIII; SRP). Gels were applied in GI and GII at baseline (T0) and 30 days later (T1). Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and Visible Plaque Index (VPI) were evaluated at (T0), 30 days (T1) and 60 days after T0 (T2). Bone density was analyzed after 18 months (T3). GII showed the most significant reduction of PPD (2.62 mm; p <0.003), and greatest gain in CAL (2.54 mm p <0.003) at T2. BOP and the VPI had a strong reduction in all groups at T2 (p <0.05), both decreased by ≥5 times and 2 times, respectively, in all groups at T1. Bone density increased in all groups in radiographs (T3). The use of DOX encapsulated in β-CD gel with SRP resulted in significant improvements in clinical periodontal parameters; such molecular inclusion of doxycycline into β-CD in gel for local application is relatively simple and useful in dentistry.

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“…The molecular arrangement of these compounds into a truncated cone gives rise to a hydrophobic internal cavity and a hydrophilic outer surface [20,21,22,23,24], which enables the use of this molecule for the formation of inclusion complexes with drugs. As such, the CDs have become the target of numerous studies concerning drug delivery systems [25,26,27,28,29,30,31,32]. For example, Silva et al described a study on the design of novel sensing and biosensing systems based on host-guest complexes [33] via the development of supramolecular structures combining Prussian blue nanoparticles, β-CDs, and layer-by-layer method.…”

Section: Introductionmentioning

confidence: 99%

New Hybrid Nanomaterial Based on Self-Assembly of Cyclodextrins and Cobalt Prussian Blue Analogue Nanocubes

Carvalho

Silva

Macedo

et al. 2015

IJMS

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Supramolecular self-assembly has been demonstrated to be a useful approach to developing new functional nanomaterials. In this work, we used a cobalt Prussian blue analogue (PBA, Co3[Co(CN)6]2) compound and a β-cyclodextrin (CD) macrocycle to develop a novel host-guest PBA-CD nanomaterial. The preparation of the functional magnetic material involved the self-assembly of CD molecules onto a PBA surface by a co-precipitation method. According to transmission electronic microscopy results, PBA-CD exhibited a polydisperse structure composed of 3D nanocubes with a mean edge length of 85 nm, which became shorter after CD incorporation. The supramolecular arrangement and structural, crystalline and thermal properties of the hybrid material were studied in detail by vibrational and electronic spectroscopies and X-ray diffraction. The cyclic voltammogram of the hybrid material in a 0.1 mol·L−1 NaCl supporting electrolyte exhibited a quasi-reversible redox process, attributed to Co2+/Co3+ conversion, with an E1/2 value of 0.46 V (vs. SCE), with higher reversibility observed for the system in the presence of CD. The standard rate constants for PBA and PBA-CD were determined to be 0.07 and 0.13 s−1, respectively, which suggests that the interaction between the nanocubes and CD at the supramolecular level improves electron transfer. We expect that the properties observed for the hybrid material make it a potential candidate for (bio)sensing designs with a desirable capability for drug delivery.

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Inclusion complex of GA-13316 with β-cyclodextrin: Preparation, characterization, molecular modeling, and in vitro evaluation

Cited by 27 publications

References 18 publications

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

New Hybrid Nanomaterial Based on Self-Assembly of Cyclodextrins and Cobalt Prussian Blue Analogue Nanocubes

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