Inclusion complex formation of α- and β-cyclodextrins with riboflavin and alloxazine in aqueous solution: thermodynamic study

Терехова, И. В.; Tikhova, Marina N.; Volkova, Тatyana V.; Kumeev, R. S.; Perlovich, German L.

doi:10.1007/s10847-010-9827-z

Cited by 23 publications

(16 citation statements)

References 26 publications

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“…Assuming that, the association constants were calculated [14] for RF either with β CD (39.7/M ± 0.31) or HP β CD (20.6/M ± 0.22). These values denote a very weak interaction between RF and CDs, and they are in good agreement with previously reported values [30,31] . It is worth noting that solubility isotherms do not establish conclusively if real complexation takes place once CDs are able to form non‐inclusion complexes which can solubilize guest molecules in aggregate structures [12,32] …”

Section: Resultssupporting

confidence: 88%

“…These values denote a very weak interaction between RF and CDs, and they are in good agreement with previously reported values. [30,31] It is worth noting that solubility isotherms do not establish conclusively if real complexation takes place once CDs are able to form non-inclusion complexes which can solubilize guest molecules in aggregate structures. [12,32] We investigated the interaction of RF with both CDs through changes in the UV-vis absorption spectrum (Figure 2a), which could provide information about the transfer of guest molecules from water to the hydrophobic cavity of CD.…”

Section: Riboflavin -Cd Non Inclusion Complexationmentioning

confidence: 99%

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Non-inclusion complexes between riboflavin and cyclodextrins

Jesus

Fraceto

Martini

et al. 2012

Journal of Pharmacy and Pharmacology

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Section: Resultssupporting

confidence: 88%

Section: Riboflavin -Cd Non Inclusion Complexationmentioning

confidence: 99%

Non-inclusion complexes between riboflavin and cyclodextrins

Jesus

Fraceto

Martini

et al. 2012

Journal of Pharmacy and Pharmacology

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“…have been shown to stabilize riboflavin via encapsulation (Terekhova, Koźbiał, Kumeev, & Alper, 2011;Terekhova, Tikhova, Volkova, Kumeev, & Perlovich, 2010;X.-M. Wang & Chen, 1996). However, the use of hydroxypropylated cyclodextrins did not show a positive effect on riboflavin stabilization (Terekhova et al, 2011).…”

Section: Stabilizationmentioning

confidence: 96%

“…Encapsulation is also a successful strategy to prevent riboflavin degradation. A range of cyclodextrins (α‐, β‐, and γ‐cyclodextrins) have been shown to stabilize riboflavin via encapsulation (Terekhova, Koźbiał, Kumeev, & Alper, ; Terekhova, Tikhova, Volkova, Kumeev, & Perlovich, ; X.‐M. Wang & Chen, ).…”

Section: Riboflavinmentioning

confidence: 99%

Vitamins in cell culture media: Stability and stabilization strategies

Schnellbaecher

Binder

Bellmaine

et al. 2019

Biotech & Bioengineering

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Nowadays, chemically defined cell culture media (CCM) have replaced serum‐ and hydrolysate‐based media that rely on complex ingredients, such as yeast extracts or peptones. Benefits include a significantly lower lot‐to‐lot variability, more efficient manufacturing by reduction to essential components, and the ability to exclude components that may negatively influence growth, viability, or productivity. Even though current chemically defined CCMs provide an excellent basis for various mammalian biotechnological processes, vitamin instabilities are known to be a key factor contributing to the variabilities still present in liquid CCM as well as to short storage times. In this review, the chemical degradation pathways and products for the most relevant vitamins for CCM will be discussed, with a focus on the effects of light, oxygen, heat, and other CCM compounds. Different approaches to stabilize vitamins in solution, such as replacement with analogs, encapsulation, or the addition of stabilizing compounds will also be reviewed. While these vitamins and vitamin stabilization approaches are presented here as particular for CCM, the application of these concepts can also be considered relevant for pharmaceutical, medical, and food supplement purposes. More precise knowledge regarding vitamin instabilities will contribute to stabilize future formulations and thus decrease residual lot‐to‐lot variability.

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“…and observed distinctly a different behavior of these dyes in these media *Corresponding author email: debabrata@iitp.ac.in (Debabrata Seth) compared to that observed in bulk media (10)(11)(12)(13)(14)(15)(16)(17). Several other workers studied different host-guest complexation using different kinds of probe molecules and using different methods (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

Photophysical Properties of 7‐(diethylamino)Coumarin‐3‐carboxylic Acid in the Nanocage of Cyclodextrins and in Different Solvents and Solvent Mixtures

Chatterjee

Seth

2012

Photochem & Photobiology

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The photophysical properties of 7-(diethylamino) coumarin-3-carboxylic acid (7-DCCA) were studied in cyclodextrins (α, β, γ,-CDs), different neat solvents and solvent mixtures by using steady state absorption, emission and time-resolved fluorescence spectroscopy. We have observed that with gradual increase in concentration of β-CD the fluorescence quantum yield and lifetime decreased in a regular pattern whereas with gradual increase in concentration of γ-CD the fluorescence quantum yield and lifetime gradually increased. With addition of urea, the fluorescence quantum yield and lifetime of 7-DCCA in CDs increased. Binding constant calculation shows that 7-DDCA forms 1:1 complex with β-CD and with γ-CD it forms 1:1 and 1:2 (guest:host) inclusion complex. We proposed that the dye molecule formed capping complex with β-CD by means of hydrogen bonding and after addition of urea the hydrogen bonding network broke down and part of dye molecule entered inside the cavity of β-CD. The photophysics of 7-DCCA was studied in dioxane-water mixture and ethylene glycol-acetonitrile mixture to know the effect of polarity and viscosity of the media. The photophysics of 7-DCCA was also studied in different neat solvents. It was found that the photophysics of 7-DCCA depended on the structural feature of the solvents and solvent mixtures.

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Inclusion complex formation of α- and β-cyclodextrins with riboflavin and alloxazine in aqueous solution: thermodynamic study

Cited by 23 publications

References 26 publications

Non-inclusion complexes between riboflavin and cyclodextrins

Non-inclusion complexes between riboflavin and cyclodextrins

Vitamins in cell culture media: Stability and stabilization strategies

Photophysical Properties of 7‐(diethylamino)Coumarin‐3‐carboxylic Acid in the Nanocage of Cyclodextrins and in Different Solvents and Solvent Mixtures

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