Incidência de acidente cerebro-vascular embólico na cardiopatia chagásica crônica

Spina-França, A.; Yasuda, N.

doi:10.1590/s0004-282x1974000300003

Arq. Neuro-Psiquiatr.

1974

DOI: 10.1590/s0004-282x1974000300003

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Incidência de acidente cerebro-vascular embólico na cardiopatia chagásica crônica

A. Spina-França

N. Yasuda

Abstract: Andrade 3 , em avaliação crítica dos aspectos anátomo-patológicos da moléstia de Chagas, relata sua experiência quanto à forma crônica da cardiopatia própria à doença. Dentre os aspectos analisados, este autor ressalta a freqüência das tromboses murais endocárdicas, responsáveis por fenômenos erabólicos tanto na circulação pulmonar, como na sistêmica.

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1997

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Cited by 2 publications

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Trypanosomiasis

Chimelli

Salvatore

1997

Brain Pathology

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African (sleeping sickness) and American (Chagas' disease) trypanosomiasis, caused by protozoa of the family Trypanosomatidae, are diseases that are endemic in parts of Africa and Latin America, respectively. Physicians in developed countries may occasionally see cases because of extensive travel and immigration from endemic countries. Although neurological involvement is common in both, its incidence and clinical presentation differ considerably. African trypanosomiasis, caused by subspecies of Trypanosoma brucei (T b rhodesiense, T b gambiense), is transmitted by the tsetse fly and causes meningoencephalitis, in which somnolence is a prominent feature. Parasites may reach the brain parenchyma through the choroid plexus or the Virchow Robin spaces. American trypanosomiasis, caused by Trypanosoma cruzi is transmitted by reduviid bugs. While lesions in the central nervous system are not prominent, except in the reactivated forms which occur in immunodeficient patients, the peripheral nerve, mainly the autonomic nervous system, is frequently involved, leading to the cardiomegaly and the digestive megaviscera. Congenital infections may also occur. In this paper we give an account of the epidemiology, clinical presentation and pathological features of these two protozoal infections based on human and experimental studies of both the central and peripheral nervous system.

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Trypanosomiasis

Chimelli

Salvatore

1997

Brain Pathology

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Anticorpos a Trypanosoma cruzi no líquido cefalorraqueano: pesquisa pelas reações de fixação do complemento e de imunofluorescência

Spina-França

Livramento

Machado

et al. 1988

Arq. Neuro-Psiquiatr.

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RESUMO -Nas amostras de líqüido cefalorraqueano (LCR) de 200 pacientes com afecções do sistema nervoso central (SNC) foi efetuada pesquisa de anticorpos a Trypanosama cruzi (T. cruzi) mediante: reação de fixação do complemento (RFC) em 69, reação de imunofluorescência (IgG) indireta (RIF) em 118, ambas em 13. Em 50 casos, para a RIF, o LCR foi também previamente concentrado 20 vezes. Os resultados foram avaliados em relação às patologias que acometiam o SNC, ao comportamento das células e proteínas do LCR e ao resultado de investigações imunológicas no LCR para outras infecções do SNC (sífilis, cisticercose, esquistossomíase e toxoplasmose) para as quais técnicas semelhantes foram adotadas. Anticorpos a T. cruzi foram demonstrados em três pacientes: em um com reagudização da moléstia de Chagas na vigência da síndrome de imunodeficiência adquirida; em um paciente com epilepsia e em um paciente com acidente vascular cerebral, ambos com moléstia de Chagas comprovada pela presença de anticorpos a T. cruzi no soro. These tests were based on techniques similar to those adopted for the search of antibodies to T. cruzi, and were conducted concomitantly to tests for T. cruzi in the same CSF sample for everyone of the cases. Antibodies to T. cruzi were found in three patients. Antibodies toThe first was a patient committed by the acquired immunodeficiency syndrome (AIDS) in whom there occurred exacerbation of the acute stage of Chagas' disease.The second is a patient who is committed by epilepsy, and an acute stroke occurred in the third patient; Chagas' disease had been previously diagnosed in them through the demonstration of antibodies to T. cruzi in the blood serum.Limitam-se as possibilidades diagnosticas de acometimento do sistema nervoso central (SNC) na forma crônica da doença de Chagas, à associação: manifestações clínicas compatíveis ao tipo de lesão encefálica comumente provocado pelo Trypanosoma cruzi (T. cruzi); presença de anticorpos ao parasita no soro do paciente. A vigência desse binômio aventa, assim, a possibilidade de diagnóstico provável.

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Incidência de acidente cerebro-vascular embólico na cardiopatia chagásica crônica

Cited by 2 publications

References 4 publications

Trypanosomiasis

Trypanosomiasis

Anticorpos a Trypanosoma cruzi no líquido cefalorraqueano: pesquisa pelas reações de fixação do complemento e de imunofluorescência

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